Periodontal Disease and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis

Abstract

Periodontal disease is a risk factor or marker for CHD that is independent of traditional CHD risk factors, including socioeconomic status. Further research in this important area of public health is warranted.

Periodontal Disease and its Association with Angiographically Verified Coronary Artery Disease

“…Prevencija CHD-a uključuje uklanjanje rizičnih čimbe-nika, a parodontitis je jedan od njih (15). Nekoliko je autora istraživalo je li potrebna rigorozna preventivna i parodontološka njega kako bi se smanjio kardiovaskularni rizik (26), popravili nalazi biomarkera i ishodi CVD-a (27) te utječe li parodontološka terapija pozitivno na smanjenje razine serumskoga C-reaktivnog proteina i na poboljšanje funkcije endotela (27,28).…”

“…Zajednički rizični čimbenici poput dijabetesa, pušenja, genetike, stresa, depresije, fizičke neaktivnosti i pretilosti otežavaju potvrdu povezanosti parodontitisa i CHD-a (10,11), no dosadašnja istraživanja pokazala su da je bez obzira na zajedničke rizične čimbenike ta povezanost moguća (12 -14). Štoviše, nedavne metaanalize potvrdile su parodontitis kao čimbenik rizika u slučaju CHDa, ili marker neovisan o tradicionalnim rizičnim čimbenicima za CAD, s relativnim rizicima u rasponu od 1,24 do 1,35 (15).…”

“…However, studies have shown such association regardless of common risk factors to be possible (12)(13)(14). Moreover, recent meta-analyses established periodontitis as a risk factor, or as a marker independent of traditional CAD risk factors, for CHD with relative risks ranging from 1.24 to 1.35 (15).…”

“…The prevention of CHD includes elimination of risk factors, with periodontitis being one of them (15). Several authors have examined the possibility that rigorous preventive and periodontal care is needed to reduce the cardiovascular risk (26) as well as to improve biomarkers and CVD outcomes (27) and that periodontal therapy has a positive effect in reducing serum C-reactive protein levels and improving the endothelial function (27,28).…”

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

“…Dentro de los procesos infecciosos crónicos estudiados por su relación con la enfermedad cardiovascular figura la periodontitis, considerada una enfermedad infecciosa de naturaleza crónica que se asocia a bacterias anaerobias que proliferan en el ambiente subgingival, entre las que se destacan: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia y Treponema denticola inducen una respuesta inmune local con repercusiones sistémicas (2)(3)(4)(5). La periodontitis parece perpetuar una respuesta sistémica mediada por antígenos de estas bacterias que activan anticuerpos, células endoteliales y monocitos generando un aumento en los niveles circulantes The family of SAA contains a number of different expressed apolipoproteins, which are synthesized by the liver.…”