Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma

Eliot, Melissa; Michaud, Dominique S.; Langevin, Scott M.; McClean, Michael D.; Kelsey, Karl T.

doi:10.1007/s10552-013-0209-x

Cited by 57 publications

(74 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding the frequency of dental visits, to date, 12 studies have been reported. [8][9][10][11][12][13]16,18,[21][22][23][24] Among them, 9 studies reported that lower frequency of dental visits is associated with an increased head and neck cancer risk, [9][10][11][12][13]16,[21][22][23] and our results were consistent with their findings.…”

Section: Discussionsupporting

confidence: 92%

Impact of oral hygiene on head and neck cancer risk in a Chinese population

Kawakita

Lee

et al. 2017

Head & Neck

View full text Add to dashboard Cite

Background Although the impact of oral hygiene on head and neck cancer (HNC) risk has been investigated, few studies have been conducted among Asians. Mehods We conducted a multicenter case-control study to investigate this potential association. We performed unconditional multiple logistic regression models adjusted by potential confounders. Results We observed an inverse association of frequency of dental visits with HNC risk, with an adjusted OR of 3.70 (2.51-5.45) for never dental visits compared with ≥1 time/year (ptrend<0.001). We also observed a positive association between the number of missing teeth and HNC risk, with an adjusted OR for ≥ 5 missing teeth compared with < 5 missing teeth of 1.49 (1.08-2.04). Combining multiple oral hygiene indicators, poor oral hygiene scores increased HNC risk. Conclusions Poor oral hygiene may increase HNC risk in a Chinese population. Improving oral hygiene may contribute to reducing HNC risk in the Chinese population.

show abstract

Section: Discussionsupporting

confidence: 92%

Impact of oral hygiene on head and neck cancer risk in a Chinese population

Kawakita

Lee

et al. 2017

Head & Neck

View full text Add to dashboard Cite

show abstract

“…Since we and others have shown that a history of allergy and a history of periodontal disease are independently associated with head and neck cancer risk (and since a humoral response could play a role in disease among those infected with HPV), we examined the data for evidence of a potential interaction between these two medical conditions and high‐risk HPV infection (including HPV16). However, we found no evidence of any significant interaction between history of allergy or history of periodontal disease with HPV infection (data not shown).…”

Section: Resultsmentioning

confidence: 99%

High‐risk HPV types and head and neck cancer

Michaud

Langevin

Eliot

et al. 2014

Intl Journal of Cancer

Self Cite

117

View full text Add to dashboard Cite

Although HPV16 has been strongly implicated in oropharyngeal carcinogenesis, the role of other high-risk HPV types in the etiology of head and neck cancer remains unclear. To date, few data exist addressing the nature of the association between antibodies to oncogenic proteins of non-HPV16 HPVs in relation to head and neck cancer. We examined the relationship between multiple HPV types (HPV6, 11, 16, 18, 31, 33, 45, 52, 58) and head and neck squamous cell carcinoma (HNSCC) in a large population-based case-control study (1069 cases and 1107 controls). Serological measures for HPV types included antibodies to L1, E6 and/or E7. In a secondary analysis, we excluded HPV16 seropositive subjects to examine independent associations with other high-risk HPVs. All analyses were adjusted for age, race, sex, education, smoking, and alcohol consumption. Statistically significant associations were observed for HPV16, 18, 33, and 52 and risk of HNSCC after mutually adjusting for HPV types. Among HPV16 seronegative subjects, elevated risks of HNSCC were observed for HPV18 E6 (OR = 4.19, 95% CI = 1.26–14.0), HPV33 E6 (OR = 7.96, 95% CI = 1.56–40.5), and HPV52 E7 (OR = 3.40, 95% CI = 1.16–9.99). When examined by tumor type, associations with HPV18 and HPV33 remained statistically significant for oropharyngeal cancer, and HPV52 was associated with oral cancer. In addition, magnitude of associations for HNSCC increased dramatically with increasing number of seropositive high-risk HPV infections. High-risk HPV types, other than HPV16, are likely to be involved in the etiology of HNSCC.

show abstract

“…Previous studies have examined the association between oral hygiene, dental health, and HNSCC. Oral health indicators, including poor dental health, tooth loss, lack of routine dental care by a dentist, and a diagnosis of periodontitis, have been associated with HNSCC . Two studies reported that periodontitis is associated with an increased risk of OPSCC without taking into account HPV status .…”

Section: Introductionmentioning

confidence: 99%

Oral health and human papillomavirus‐associated head and neck squamous cell carcinoma

Mazul

Taylor

Divaris

et al. 2016

Cancer

View full text Add to dashboard Cite

Background Indicators of poor oral health, including smoking, have been associated with increased risk of head and neck squamous cell carcinoma, especially oropharyngeal carcinoma (OPSCC), yet few studies have examined whether this association is modified by HPV-status. Methods We used interview and tumor HPV-status data from a large population-based case-control study, the Carolina Head and Neck Cancer Study (CHANCE), to estimate the association between oral health indicators and smoking among 102 HPV-positive and 145 HPV-negative OPSCC cases and 1396 controls. HPV-status was determined by immunohistochemistry of p16INK4a expression. Unconditional multinomial logistic regression was used to estimate odds ratios (OR) for all oral health indictors adjusting for important covariates. Results Routine dental exams were associated with decreased risk of both HPV-negative [OR: 0.52; 95% confidence interval (CI): 0.35-0.76] and HPV-positive OPSCC (OR: 0.55; 95% CI: 0.36-.86). Tooth mobility (a proxy for periodontal disease) increased the risk of HPV-negative (OR: 1.70; 95% CI: 1.18-2.43) slightly more than HPV-positive OPSCC (OR: 1.45; 95% CI: 0.95-2.20). Ten or more pack-years of cigarette smoking was strongly associated with increased risk of HPV-negative OPSCC (OR: 4.26; 95% CI: 2.85-6.37) and less so with HPV-positive OPSCC (OR: 1.62; 95% CI: 1.10-2.38). Conclusions While HPV-positive and HPV-negative HNSCC differ significantly with respect to etiology and tumorigenesis, our findings suggest a similar pattern of association between poor oral health, frequency of dental examinations, and both HPV-positive and HPV-negative OPSCC. Future research is required to elucidate interactions between poor oral health, tobacco use, and HPV in the development of OPSCC.

show abstract

Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma

Cited by 57 publications

References 34 publications

Impact of oral hygiene on head and neck cancer risk in a Chinese population

Impact of oral hygiene on head and neck cancer risk in a Chinese population

High‐risk HPV types and head and neck cancer

Oral health and human papillomavirus‐associated head and neck squamous cell carcinoma

Contact Info

Product

Resources

About