Periodontal Disease and Pregnancy Outcomes: Time to Move On?

Srinivas, Sindhu K.; Parry, Samuel

doi:10.1089/jwh.2011.3023

Cited by 43 publications

(46 citation statements)

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“…Current evidence from RCTs does not support the provision of periodontal therapy to improve pregnancy outcomes. It may be time to focus on other aetiologies and methods to reduce the rate of adverse pregnancy outcomes, including preterm birth (Srinivas & Parry 2012).…”

Section: Discussionmentioning

confidence: 99%

The effects of periodontal treatment on pregnancy outcomes

Michalowicz

Gustafsson

Thumbigere‐Math

et al. 2013

Journal of Periodontology

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Background: Preterm infants are at greater risk than term infants for physical and developmental disorders. Morbidity and mortality increases as gestational age at delivery decreases. Observational studies indicate an association between poor periodontal health and risk for preterm birth or low birthweight, making periodontitis a potentially modifiable risk factor for prematurity. Aim: To identify randomized controlled trials (RCTs) published between January 2011 and July 2012 and discuss all published RCTs testing whether periodontal therapy reduces rates of preterm birth and low birthweight. Methods: Search of databases including PubMed, ISI Web of Science and Cochrane Library. Results: The single RCT identified showed no significant effect of periodontal treatment on birth outcomes. Discussion: All published trials included non‐surgical periodontal therapy; only two included systemic antimicrobials as part of test therapy. The trials varied substantially in terms of sample size, obstetric histories of subjects, study preterm birth rates and the periodontal treatment response. The largest trials – also judged to be high‐quality and at low risk of bias – have yielded consistent results, and indicate that treatment does not alter rates of adverse pregnancy outcomes. Conclusion: Non‐surgical periodontal therapy, scaling and root planing, does not improve birth outcomes in pregnant women with periodontitis.

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Section: Discussionmentioning

confidence: 99%

The effects of periodontal treatment on pregnancy outcomes

Michalowicz

Gustafsson

Thumbigere‐Math

et al. 2013

Journal of Periodontology

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“…Experimental infection in various animal models confirms that invasion of the uterine compartment by P. gingivalis produces a diverse array of APO, including utero-placental pathology, enhanced expression of pro-T helper (TH)1 type cytokines (IFN-γ, IL-2, IL-12, and TNF-α), fetal growth restriction (FGR), and spontaneous preterm delivery [12][13][14][15]. Since these outcomes are manifestations of different pathologic mechanisms within the fetal compartment, it may seem somewhat perplexing that one organism could be responsible for all of these complications.…”

Section: Introductionmentioning

confidence: 97%

“…However, the significance of P. gingivalis as a causative agent of APO is sometimes viewed with skepticism due to several confounding factors. For instance, periodontal disease in of itself is a poor predictor of preterm birth, preeclampsia, fetal growth restriction, or perinatal death [2,12]. Moreover, a consensus of interventional studies in which pregnant women received periodontal treatment did not show an overall significant reduction in the rate of preterm birth, fetal growth restriction, low birth weight, stillbirth, or miscarriage in these cohorts [2,12].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, periodontal disease in of itself is a poor predictor of preterm birth, preeclampsia, fetal growth restriction, or perinatal death [2,12]. Moreover, a consensus of interventional studies in which pregnant women received periodontal treatment did not show an overall significant reduction in the rate of preterm birth, fetal growth restriction, low birth weight, stillbirth, or miscarriage in these cohorts [2,12]. Also confounding is that P. gingivalis DNA or antigen has also been detected in placentas from healthy pregnancies, albeit at a lower microbial load and lower frequency than women with preeclampsia or preterm birth [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Porphyromonas gingivalisand adverse pregnancy outcome

Reyes

Phillips

Wolfe

et al. 2017

Journal of Oral Microbiology

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Porphyromonas gingivalis is a Gram-negative, anaerobic bacterium considered to be an important pathogen of periodontal disease that is also implicated in adverse pregnancy outcome (APO). Until recently, our understanding of the role of P. gingivalis in APO has been limited and sometimes contradictory. The purpose of this review is to provide an overview of past and current research on P. gingivalis that addresses some of the controversies concerning the role of this organism in the pathogenesis of APO.ARTICLE HISTORY

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“…Approximately 40% of pregnant women have some form of periodontal disease (Srinivas and Parry, 2012). Periodontitis has been shown to contribute to premature birth, thus increasing the risk for low birth weight, and preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Pregnant Women Knowledge Regard Oral Health Care

Mohamed

Fahmy

Soliman

2019

Egyptian Journal of Health Care

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This study was aimed to assess pregnant women knowledge regarding the oral health care. Study setting: The study was conducted at ante natal outpatient clinic At Ain Shams University Maternity Hospital. Study design: A descriptive study design was used. subjects and method :The study was conducted among pregnant women were attended at antenatal outpatient clinic At Ain Shams University Hospital 265. Study simple: Purposive sample. Study Tools: Selfadministered structured questionnaire sheet, was developed to collect data. Result: There were three quarters of study sample of pregnant women had unsatisfactory knowledge about oral health care during pregnancy. Conclusion: the current study concluded that most of the study sample had unsatisfactory knowledge regard oral health care during their pregnancy period. Recommendations: Emphasize the importance of oral health care during pregnancy to prevent the oral health problems for both mothers and their infants.

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Periodontal Disease and Pregnancy Outcomes: Time to Move On?

Cited by 43 publications

References 50 publications

The effects of periodontal treatment on pregnancy outcomes

The effects of periodontal treatment on pregnancy outcomes

Porphyromonas gingivalisand adverse pregnancy outcome

Pregnant Women Knowledge Regard Oral Health Care

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