Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study

Michaud, Dominique S.; Kelsey, Karl T.; Papathanasiou, Evgenia; Genco, Caroline A.; Giovannucci, Edward

doi:10.1093/annonc/mdw028

Cited by 123 publications

(161 citation statements)

References 31 publications

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“…Studies of oral disease and cancer provide evidence that oral health (tooth loss, poor oral hygiene, and possibly periodontal disease) is linked to esophageal cancer risk (14,36–38). We observed that Tannerella forsythia was associated with higher EAC risk, and Porphyromonas gingivalis with ESCC risk.…”

Section: Discussionmentioning

confidence: 99%

“…Cross-sectional studies report distinct differences in upper digestive tract microbiota between GERD (7–9), Barrett’s esophagus (BE, an EAC precursor) (7–10), EAC (7,11), esophageal squamous dysplasia (ESD, an ESCC precursor) (12), or ESCC (13) cases and controls. Additionally, periodontitis (a disease of oral dysbiosis) may be associated with increased esophageal cancer risk (14). However, no studies have prospectively examined whether upper digestive tract microbiota influence risk for subsequent esophageal cancer.…”

Section: Introductionmentioning

confidence: 99%

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Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers

et al. 2017

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Bacteria may play a role in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), although evidence is limited to cross-sectional studies. In this study, we examined the relationship of oral microbiota with EAC and ESCC risk in a prospective study nested in two cohorts. Oral bacteria were assessed using 16S rRNA gene sequencing in pre-diagnostic mouthwash samples from n=81/160 EAC and n=25/50 ESCC cases/matched controls. Findings were largely consistent across both cohorts. Metagenome content was predicted using PiCRUST. We examined associations between centered log-ratio transformed taxon or functional pathway abundances and risk using conditional logistic regression adjusting for BMI, smoking, and alcohol. We found the periodontal pathogen Tannerella forsythia to be associated with higher risk of EAC. Further, we found that depletion of the commensal genus Neisseria and the species Streptococcus pneumoniae were associated with lower EAC risk. Bacterial biosynthesis of carotenoids was also associated with protection against EAC. Lastly, the abundance of the periodontal pathogen Porphyromonas gingivalis trended with higher risk of ESCC. Overall, our findings have potential implications for the early detection and prevention of EAC and ESCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers

et al. 2017

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“…Meanwhile, periodontitis has long been recognized as a pathogenic state of biofilm-induced inflammation (62, 64, 65). F. nucleatum and Porphyromonas spp.…”

Section: The Oral Microbiota and Head And Neck Cancersmentioning

confidence: 99%

“…One recent study (65) indicated that advanced periodontitis was associated with a 2.5-fold increase in lung cancer among people who never smoked. Periodontitis-related lung cancer has been proposed to result from inflammatory immune responses initiated in the oral cavity that modify the respiratory epithelium and promote carcinogenesis (96), but the responsive immune cell populations and cytokines involved in the biological mechanisms remain undetermined.…”

Section: The Oral and Lung Microbiota In Lung Cancermentioning

confidence: 99%

Microbiota dysbiosis in select human cancers: Evidence of association and causality

Chen

Domingue

Sears

2017

Seminars in Immunology

146

111

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The human microbiota is a complex ecosystem of diverse microorganisms consisting of bacteria, viruses, and fungi residing predominantly in epidermal and mucosal habitats across the body, such as skin, oral cavity, lung, intestine and vagina. These symbiotic communities in health, or dysbiotic communities in disease, display tremendous interaction with the local environment and systemic responses, playing a critical role in the host’s nutrition, immunity, metabolism and diseases including cancers. While the profiling of normal microbiota in healthy populations is useful and necessary, more recent studies have focused on the microbiota associated with disease, particularly cancers. In this paper, we review current evidence on the role of the human microbiota in four cancer types (colorectal cancer, head and neck cancer, pancreatic cancer, and lung cancer) proposed as affected by both the oral and gut microbiota, and provide a perspective on current gaps in the knowledge of the microbiota and cancer.

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“…Advanced periodontal disease also has well-established systemic inflammatory effects, extending beyond the oral cavity [6]. Further, there is increasing evidence that periodontal disease is linked to chronic diseases, including cardiovascular disease [7, 8], stroke [9], diabetes [10], and cancer [11–14]. …”

Section: Introductionmentioning

confidence: 99%

Periodontal disease and risk of non‐Hodgkin lymphoma in the Health Professionals Follow‐Up Study

Bertrand

Shingala

Evens

et al. 2016

Intl Journal of Cancer

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Periodontal disease is a chronic inflammatory condition that has been associated with chronic diseases, including cancer. In an earlier prospective cohort analysis within the Health Professionals Follow-Up Study (HPFS), we observed a 31% higher risk of non-Hodgkin lymphoma (NHL) among participants with severe periodontal disease at baseline. Here, we extend the study with an additional 8 years of follow-up, and conduct analyses with updated periodontal disease status and NHL subtypes. The HPFS is an ongoing prospective cohort study of 51,529 men in the U.S. Between baseline in 1986 and 2012, 875 cases of NHL were diagnosed, including 290 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 85 diffuse large B-cell lymphomas, and 91 follicular lymphomas. We performed multivariable Cox proportional hazards regression to evaluate associations of interest. History of periodontal disease at baseline was positively associated with risk of NHL overall (hazard ratio (HR) = 1.26, 95% confidence interval (CI): 1.06–1.49) and CLL/SLL (HR = 1.41, 95% CI: 1.04–1.90). With updated periodontal status, HRs were 1.30, (95% CI: 1.11–1.51) for NHL overall and 1.41 (95% CI: 1.08–1.84) for CLL/SLL. In contrast, after adjusting for periodontal disease, tooth loss was inversely associated with NHL, suggesting that other causes or consequences of tooth loss may have different implications for NHL etiology. Our findings suggest that periodontal disease is a risk factor for NHL. Whether periodontal disease is a direct or indirect cause of NHL, or is a marker of underlying systemic inflammation and/or immune dysregulation, warrants further investigation.

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Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study

Cited by 123 publications

References 31 publications

Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers

Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers

Microbiota dysbiosis in select human cancers: Evidence of association and causality

Periodontal disease and risk of non‐Hodgkin lymphoma in the Health Professionals Follow‐Up Study

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