Periodontal Disease and Systemic Interactions (Periodontal Medicine): Current Epidemiological Evidence

Beck, James D.; Philips, Kamaira; Rao, Sanjana S.

doi:10.1007/s40496-020-00248-4

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…Systemic inflammation is associated with cognitive decline and the development of dementia [7] . Periodontitis is a common disease in oral diseases, which is an inflammatory disease caused by microorganisms that can lead to periodontal attachment loss [8,9] .Periodontal bacteria can transfer from periodontal tissue into the bloodstream through blood-borne transmission or release of mediators of inflammation, leading to the development of bacteremia or systemic inflammation [10] .A large amount of epidemiological evidence has shown that there is a certain link with periodontitis and the occurrence of many systemic diseases such as diabetes, atherosclerosis and so on [11][12][13] . In recent years, studies between periodontal disease and cognitive impairment have also received increasing attention from scholars [4,14,15] .…”

Section: Correlation Between Periodontitis and Cognitive Impairmentmentioning

confidence: 99%

Research progress on the relationship between cognitive impairment and oral health

2022

FMSR

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With the intensification of the aging of population, the number of patients with neurodegenerative diseases such as cognitive impairment is increasing. Patients with cognitive impairment often have poor oral health, which previous studies have suggested that may be related to poor oral hygiene habits. However, studies in recent years have shown that oral diseases may accelerate the development of cognitive impairment through infections and other routes. In this article, the correlation and possible mechanisms of oral health including periodontitis, masticatory function, and oral mucosal disease and cognitive impairment will be elaborated.

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Section: Correlation Between Periodontitis and Cognitive Impairmentmentioning

confidence: 99%

Research progress on the relationship between cognitive impairment and oral health

2022

FMSR

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“…On the other hand, the systemic chronic inflammation caused by periodontitis also appears to play an important role in the aforementioned systemic diseases. A previous study has shown that periodontitis is associated with the risk factors of cardiovascular disease via proinflammatory markers such as interleukin (IL)-6, tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP), and periodontal therapy can reduce the risk of cardiovascular disease by reducing these biomarkers ( 12 ). The European Federation of Periodontology and the International Diabetes Federation indicated that the associated mechanisms between periodontitis and diabetes included the expression of inflammation-related molecules such as IL-1β, TNF-α, IL-6, nuclear factor B-receptor activator ligand, and Toll-like receptor (TLR) 2 and 4, and suggested that professional periodontal therapy may help reduce glycated hemoglobin (HbA1C) in patients with diabetes ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Advances in the relationship between periodontopathogens and respiratory diseases (Review)

Zhang,

Wen,

Liu

et al. 2024

Mol Med Rep

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Periodontitis is a common chronic inflammatory and destructive disease in the mouth and is considered to be associated with systemic diseases. Accumulating evidence has suggested that periodontitis is a risk factor for pulmonary diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, coronavirus disease 2019 (COVID-19) and lung cancer. The presence of common periodontal pathogens has been detected in samples from a variety of pulmonary diseases. Periodontal pathogens can be involved in lung diseases by promoting the adhesion and invasion of respiratory pathogens, regulating the apoptosis of respiratory epithelium and inducing overexpression of mucin and disrupting the balance of immune systemin respiratory epithelium cells. Additionally, measures to control plaque and maintain the health of periodontal tissue can decrease the incidence of respiratory adverse events. This evidence suggests a close association between periodontitis and pulmonary diseases. The present study aimed to review the clinical association between periodontitis and pneumonia, COPD, asthma, COVID-19 and lung cancer, and propose a possible mechanism and potential role of periodontal pathogens in linking periodontal disease and lung disease. This could provide a direction for further research on the association between periodontitis and lung disease and provide novel ideas for the clinical diagnosis and treatment management of these two diseases.

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Periodontal Disease and Systemic Interactions (Periodontal Medicine): Current Epidemiological Evidence

Cited by 2 publications

References 59 publications

Research progress on the relationship between cognitive impairment and oral health

Research progress on the relationship between cognitive impairment and oral health

Advances in the relationship between periodontopathogens and respiratory diseases (Review)

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