Periodontal disease as a risk factor for sporadic colorectal cancer: results from COLDENT study

Janati, Amal Idrissi; Karp, Igor; Latulippe, Jean-François; Charlebois, Patrick; Emami, Elham

doi:10.1007/s10552-021-01541-y

Cited by 11 publications

(5 citation statements)

References 51 publications

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“…Participants were administered a multi-item study-questionnaire that had been used by the research team in a previous population-based case–control study, COLDENT study, investigating the association between PD and sporadic CRC 32 . The questionnaire included different sections on sociodemographic and medical history information, cigarette smoking, anthropometric measures, non-steroidal anti-inflammatory drugs use, oral health, dietary habits, and total physical activity 32 – 36 . A life-course approach was used to document cumulative long-term history regarding cigarette smoking, specific dietary habits, and physical activity.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, collected data enabled the description of study participants regarding sociodemographic characteristics, periodontal health status, as well as potential risk factors of CRN/CRC, namely age, gender, education attainment, income, body mass index, history of type II diabetes, history of CRC in first-degree relatives, history of regular use of non-steroidal anti-inflammatory drugs, lifetime cumulative cigarette smoking, consumption of red meats, processed meats, and total alcoholic drinks since early adulthood, as well as lifetime total physical activity score. Positive history of PD was defined as self-reported PD with bone loss, a previous professional diagnosis or treatment of PD, or history of clinical symptoms and complications of the disease, such as frequent gum bleeding, tooth mobility, or tooth loss because of PD or tooth mobility 32 .…”

Section: Methodsmentioning

confidence: 99%

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Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a pilot study

Janati

Karp

Renteln

et al. 2022

Sci Rep

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As evidence has been linking the oral bacterium Fusobacterium nucleatum (F. nucleatum) to colorectal tumorigenesis, we aimed to produce preliminary data on the expression of F. nucleatum in both oral and colorectal body sites in cases diagnosed with colorectal neoplasms (CRN) and CRN-free controls. We conducted a pilot hospital-based case–control study among patients who underwent colonoscopy examination. Saliva samples and biopsies from healthy colon mucosa from CRN cases and CRN-free controls, and from tumors in cases, were collected, as well as data on periodontal condition and potential CRN risk factors. A total of 22 CRN cases and 21 CRN-free controls participated in this study, with a total of 135 biospecimens collected and analyzed by qPCR for detection and quantification of F. nucleatum. The detection rate of F. nucleatum was 95% in saliva samples and 18% in colorectal mucosa specimens. The median (95% CI) salivary F. nucleatum level was 0.35 (0.15–0.82) and 0.12 (0.05–0.65) in case and control groups, respectively, with a Spearman correlation of 0.64 (95% CI 0.2–0.94) between F. nucleatum level in saliva and healthy colorectal mucosa in controls. Our study results support the need for and the feasibility of further studies that aim to investigate the association between oral and colorectal levels of F. nucleatum in CRN cases and controls.Clinical Relevance: Considering the current evidence linking F. nucleatum to colorectal carcinogenesis, investigating the role of oral F. nucleatum expression in its colorectal enrichment is crucial for colorectal cancer screening and prevention avenues.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a pilot study

Janati

Karp

Renteln

et al. 2022

Sci Rep

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“…Periodontitis plays an active role in the pathogenesis of human CRC and the rate of new diagnosis of CRC in persons with a positive history of periodontal disease was 1.45 times higher than in those with the negative history after adjusting for a number of potential confounders ( 93 , 94 ). Upon growing evidences, F. nucleatum was shown to be highly abundant in CRC and could be a causative agent of CRC.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Fusobacterium nucleatum in malignancies except for colorectal cancer: A literature review

Tian

Wei

et al. 2022

Front. Immunol.

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Fusobacterium nucleatum (F. nucleatum) is originally an oral opportunistic pathogen and accumulating evidence links the presence of F. nucleatum with the pathogenicity, development, and prognosis of colorectal cancer (CRC). However, only limited preliminary data is available dealing with the role of F. nucleatum in other malignancies except for CRC. The present review aims to update and systematize the latest information about the mechanisms of F. nucleatum-mediating carcinogenesis, together with the detection rates, clinicopathological, and molecular features in F. nucleatum-associated malignancies. Comparing with adjacent non-tumorous tissue, previous studies have shown an overabundance of intratumoural F. nucleatum. Although the prognostic role of F. nucleatum is still controversial, a higher prevalence of F. nucleatum was usually associated with a more advanced tumor stage and a worse overall survival. Preliminary evidence have shown that epithelial-to-mesenchymal transition (EMT) and relevant inflammation and immune response aroused by F. nucleatum may be the probable link between F. nucleatum infection and the initiation of oral/head and neck cancer. Further studies are needed to elucidate the etiologic role of the specific microbiota and the connection between the extent of periodontitis and carcinogenesis in different tumor types. The mechanisms of how the antibiotics exerts the critical role in the carcinogenesis and antitumor effects in malignancies other than CRC need to be further explored.

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“…The overlapping association of P. micra , F. nucleatum , and various other prominent oral pathobionts in inflammatory infections and different cancers is both striking and intriguing. For example, periodontal disease has been recently identified as a risk factor for CRC (Janati et al, 2022 ). It seems somewhat counterintuitive that tumours found in the colon would exhibit infiltration from oral bacteria, given the physical proximity of these tumours to the multitude of colonic bacterial species comprising the most microbially rich environment in the human body.…”

Section: Discussionmentioning

confidence: 99%

Who is in the driver's seat? Parvimonas micra: An understudied pathobiont at the crossroads of dysbiotic disease and cancer

Higashi

Krieger

Qin

et al. 2023

Environ Microbiol Rep

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Recent advances in our understanding of microbiome composition at sites of inflammatory dysbiosis have triggered a substantial interest in a variety of historically understudied bacteria, especially among fastidious obligate anaerobes. A plethora of new evidence suggests that these microbes play outsized roles in establishing synergistic polymicrobial infections at many different sites in the human body. Parvimonas micra is a prime example of such an organism. Despite being almost completely uncharacterized at the genetic level, it is one of the few species commonly detected in abundance at multiple mucosal sites experiencing either chronic or acute inflammatory diseases, and more recently, it has been proposed as a discriminating biomarker for multiple types of malignancies. In the absence of disease, P. micra is commonly found in low abundance, typically residing within the oral cavity and gastrointestinal tract. P. micra exhibits the typical features of an inflammophilic organism, meaning its growth actually benefits from active inflammation and inflammatory tissue destruction. In this mini‐review, we will describe our current understanding of this underappreciated but ubiquitous pathobiont, specifically focusing upon the role of P. micra in polymicrobial inflammatory dysbiosis and cancer as well as the key emerging questions regarding its pathobiology. Through this timely work, we highlight Parvimonas micra as a significant driver of disease and discuss its unique position at the crossroads of dysbiosis and cancer.

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Periodontal disease as a risk factor for sporadic colorectal cancer: results from COLDENT study

Cited by 11 publications

References 51 publications

Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a pilot study

Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a pilot study

Involvement of Fusobacterium nucleatum in malignancies except for colorectal cancer: A literature review

Who is in the driver's seat? Parvimonas micra: An understudied pathobiont at the crossroads of dysbiotic disease and cancer

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