Periodontal disease is significantly higher in non-smoking treatment-naive rheumatoid arthritis patients: results from a case-control study

Potikuri, Damodaram; Dannana, Kalyan Chakravarthy; Suresh, Kanchinadam; Agrawal, Shruti; Anuradha, K.; Rajasekhar, Liza; Pothuraju, Shantakumari; Narsimulu, G

doi:10.1136/annrheumdis-2011-200380

Cited by 76 publications

(81 citation statements)

References 24 publications

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“…In light of recent observations of the presence of inflammation-associated citrullination, presence of PAD-2 and PAD-4 in gingival tissues [28], [48] as well as PPAD in serum [49] now provides good evidence for another important extra-articular source for citrullination and anti-citrullinated protein antibody production to occur years in advance of the development of the clinical signs and symptoms of RA. In this regard it is significant that individuals with untreated RA who are non-smokers but presenting with chronic periodontitis have a significantly high level of anti-citrullinated protein antibody titres [50].…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis

et al. 2014

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ObjectivesTo investigate the suggested role of Porphyromonas gingivalis peptidylarginine deiminase (PAD) in the relationship between the aetiology of periodontal disease and experimentally induced arthritis and the possible association between these two conditions.MethodsA genetically modified PAD-deficient strain of P. gingivalis W50 was produced. The effect of this strain, compared to the wild type, in an established murine model for experimental periodontitis and experimental arthritis was assessed. Experimental periodontitis was induced following oral inoculation with the PAD-deficient and wild type strains of P. gingivalis. Experimental arthritis was induced via the collagen antibody induction process and was monitored by assessment of paw swelling and micro-CT analysis of the radio-carpal joints. Experimental periodontitis was monitored by micro CT scans of the mandible and histological assessment of the periodontal tissues around the mandibular molars. Serum levels of anti-citrullinated protein antibodies (ACPA) and P. gingivalis were assessed by ELISA.ResultsThe development of experimental periodontitis was significantly reduced in the presence of the PAD-deficient P. gingivalis strain. When experimental arthritis was induced in the presence of the PAD-deficient strain there was less paw swelling, less erosive bone damage to the joints and reduced serum ACPA levels when compared to the wild type P. gingivalis inoculated group.ConclusionThis study has demonstrated that a PAD-deficient strain of P. gingivalis was associated with significantly reduced periodontal inflammation. In addition the extent of experimental arthritis was significantly reduced in animals exposed to prior induction of periodontal disease through oral inoculation of the PAD-deficient strain versus the wild type. This adds further evidence to the potential role for P. gingivalis and its PAD in the pathogenesis of periodontitis and exacerbation of arthritis. Further studies are now needed to elucidate the mechanisms which drive these processes.

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Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis

et al. 2014

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“…31,32 The human microbiome plays important roles in immune regulation and self-tolerance. 33 Disturbance of the intestinal microbiome has been linked to several autoimmune diseases, including IBD, 34,35 rheumatoid arthritis, [36][37][38][39][40] and at least 1 category of JIA. 14 After antibiotic treatment, commensal microbial populations often recover within ∼3 months, including in young children.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case–Control Study

et al. 2015

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“…An important confounder that has been variably reported is smoking status. Although smoking is a well recognized shared risk for rheumatoid arthritis and periodontal disease, Potikuri et al [26 ■■ ] recently reported that the associations are present in nonsmoking rheumatoid arthritis patients.…”

Section: Association Studies Between Periodontal Disease and Rheumatomentioning

confidence: 99%

“…A number of studies [26 ■■ ,58,59 ■ ,60 ■ ] have evaluated whether exposure to Pg is seen in rheumatoid arthritis and whether exposure is associated with rheumatoid arthritis autoantibodies. Using an antibody against Pg , Mikuls et al [58] demonstrated that anti Pg presence and titers were higher in rheumatoid arthritis than controls.…”

Section: Clinical Studies Of P Gingivalis In Rheumatoid Arthritismentioning

confidence: 99%

Periodontal disease and rheumatoid arthritis

Bingham

Moni

2013

Current Opinion in Rheumatology

145

106

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Purpose of review This review was conducted to focus on the recent clinical and translational research related to the associations between periodontal disease and rheumatoid arthritis. Recent findings There is a growing interest in the associations between oral health and autoimmune and inflammatory diseases. A number of epidemiologic studies have described associations between rheumatoid arthritis and periodontal disease. Recent clinical studies continue to support these reports, and are increasingly linked with biological assessments to better understand the nature of these relationships. A number of recent studies have evaluated the periopathogenic roles of Porphyromonas gingivalis, the oral microbiome, and mechanisms of site-specific and substrate-specific citrullination. These are helping to further elucidate the interactions between these two inflammatory disease processes. Summary Studies of clinical oral health parameters, the gingival microenvironment, autoantibodies and biomarkers, and rheumatoid arthritis disease activity measures are providing a better understanding of the potential mechanisms responsible for rheumatoid arthritis and periodontal disease associations. The cumulative results and ongoing studies have the promise to identify novel mechanisms and interventional strategies to improve patient outcomes for both conditions.

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Periodontal disease is significantly higher in non-smoking treatment-naive rheumatoid arthritis patients: results from a case-control study

Abstract: PD is more frequent and severe in non-smoking DMARD-naive RA patients compared with healthy controls. PD in RA is associated with high titres of ACPAs.

Cited by 76 publications

References 24 publications

Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis

Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis

Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case–Control Study

Periodontal disease and rheumatoid arthritis

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