Periodontal diseases and stress: a brief review

Akcalı, Aliye; Huck, Olivier; Tenenbaum, Henri; Davideau, Jean‐Luc; Buduneli, Nurcan

doi:10.1111/j.1365-2842.2012.02341.x

Cited by 77 publications

(79 citation statements)

References 90 publications

(115 reference statements)

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“…From there, studies conducted on animals [19][20][21] and on people, whether it be cohort, cross-sectional, case-control or clinical trials [6,15,28,22] showed a positive correlation between stress and the occurrence of periodontal disease. According to several recent literature reviews, the evidence is currently sufficient to suggest that stress is a risk factor for the occurrence of periodontal disease in the presence of pathogens as well as the worsening of pre-existing periodontal diseases [8,12,15,17,[23][24][25][26].…”

Section: Progressive Establishment Of the Link Between Chronic Stressmentioning

confidence: 99%

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Impact of chronic stress on periodontal health

Gunepin¹,

Derache

Trousselard³

et al. 2018

J Oral Med Oral Surg

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--Introduction: Periodontal diseases are caused by pathogenic microorganisms that induce increases in of local and systemic proinflammatory cytokines, resulting in periodontal damage. The onset and evolution of periodontal diseases are influenced by many local and systemic risk factors. Educational objective: In this article, we aim to review the results of the research on the impact of chronic stress on the occurrence, development, and response to periodontal disease treatments and on the pathophysiological mechanisms of periodontal disease. Conclusion: Chronic stress has a negative impact on the occurrence, development, and response to the treatment of periodontal disease via indirect actions on the periodontium. This can result from behavioral changes caused by stress (poor dental hygiene, smoking, etc.) and a direct neuroimmunoendocrinological action related to the consequences (particularly immunological) of the secretion of certain chemicals (e.g., cortisol) induced by the activation of the hypothalamus and the autonomic nervous system in response to stress. These factors necessitate multidisciplinary management (e.g., physician, oral surgeon, and psychologist) of patients to identify subjects with chronic stress and to employ countermeasures to decrease the impact of stress on the periodontium.

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Section: Progressive Establishment Of the Link Between Chronic Stressmentioning

confidence: 99%

“…Overconsumption of high-fat foods induced by stress can lead to increased cortisol production and thus immunosuppression [35,37]. Any changes to diet can cause stress and can be a risk factor for periodontal disease [25,35].…”

Section: Changes To Dietmentioning

confidence: 99%

Impact of chronic stress on periodontal health

Gunepin¹,

Derache

Trousselard³

et al. 2018

J Oral Med Oral Surg

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“…There are several main causal risk factors, (i) the subgingival bacterial biofilm on both the tooth root surface and on the pocket epithelial lining (12), (ii) genetic risk factors and epigenetic modifications (9,13,14), (iii) life style related risk factors, such as smoking, stress and poor diet or micronutrients intake (15)(16)(17), (iv) systemic disease, notably diabetes (18) and (v) others factors as of yet unknown, but possibly occlusal disturbances or fremitus, iatrogenic aspects (19) (Figure 1). …”

Section: Periodontitis Is a Complex Diseasementioning

confidence: 99%

What is the Contribution of Genetics to Periodontal Risk?

Loos

Papantonopoulos

Jepsen

et al. 2015

Dental Clinics of North America

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This review addresses the multi-causal etiology of periodontitis, in which genetic factors play a role. The various proposed causes for periodontitis always play a role simultaneously, but the relative contribution of each of these, varies from case to case. In young individuals often with aggressive periodontitis (AgP) a stronger contribution from genetic factors is apparent, while in older individuals often with chronic periodontitis (CP), the relative contribution of the established subgingival biofilms (environmental factors) and life style factors (e.g. smoking, stress, diet), play a more dominant role in the phenotype of the disease.Nevertheless always some genetic susceptibility is present, for CP estimated at 25%.Periodontitis is therefore a complex disease, i.e. it behaves in a nonlinear fashion. Actually the disease progression rate fluctuates, where the disease sometimes moves into an aberrant state of host response and then swings back into a resolving state; in between, a settlement zone is present where essentially no differences are found for immunological parameters between cases with periodontitis and healthy controls. The genotype determines part of this fluctuation and the extent of it. The disease is polygenic, i.e. multiple genetic variants in multiple genes determine the phenotype, but there are individual and ethnic differences in the genes involved. We are still at the early stage to have identified the involved genes, in comparisons to other chronic diseases, we need to count on it that at least 100 causative genes across various global populations exist in AgP and CP. To date, the genetic variations firmly and repeatedly associated with periodontitis in some populations are found within the following genes: ANRIL, COX2, IL1, IL10, DEFB1, while many proposed periodontitis candidate genes have not been firmly proven or replicated. 3 KeypointsPeriodontitis is a multi-causal disease, with each of the causal factors playing a role but the relative contribution of these vary form case to case.The disease behaves in a nonlinear fashion, with periods of aberrant host response to periods within an active disease resolving state.To date only a few of the multitude of possible genetic factors for periodontitis are identified. Outline

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“…Elevation of salivary alpha-amylase activity correlated with elevation of the CPI value, but not the OHI value. Periodontal disease is reported to relate to physical and emotional stress 37) . The results of our study suggest that stress could have made the periodontal condition worse in a stressed participant, even if their oral hygiene was good.…”

Section: Discussionmentioning

confidence: 99%

Intraoral electric potential <i>via</i> oral bacterial power generation —A novel mechanism of biofilm formation

et al. 2017

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In the early stages of biofilm accumulation, the electric charge of the dental enamel and pellicle surfaces is known to be involved. We therefore investigated the relationship between oral hygiene and intraoral electric potential (IoP) in 45 male participants using a double-blind study. IoP, but not body surface electric potential, was loosely correlated with oral hygiene condition (Oral Hygiene Index; OHI). IoP was also loosely correlated with smartphone use; however, there was no significant correlation between smartphone use and OHI. IoP elevation might be caused by OHI elevation resulting from biofilm formation as an internal factor, with smartphone use as an external factor. This in vitro study revealed the generating capacity of Streptococcus mutans accompanied by biofilm accumulation using a microbial fuel cell. These results suggest that IoP elevation is caused by biofilm accumulation induced by power generation of oral bacteria, resulting in elevation of OHI.

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Periodontal diseases and stress: a brief review

Cited by 77 publications

References 90 publications

Impact of chronic stress on periodontal health

Impact of chronic stress on periodontal health

What is the Contribution of Genetics to Periodontal Risk?

Intraoral electric potential <i>via</i> oral bacterial power generation —A novel mechanism of biofilm formation

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