Chronic periodontitis and chronic obstructive pulmonary disease (COPD) are chronic inlammatory diseases in which neutrophilic inlammation plays a major role. There are a few studies showing that these two entities share various predisposing factors and pathogenetic mechanisms; however, a direct connection between them has not yet been achieved. Epidemiology data may also show a connection between the two conditions. Neutrophilic inlammation in periodontitis and COPD is orchestrated by CD8+ lymphocytes and macrophages, leading to the aggregation of neutrophils and causing an imbalance to the proteases and antiproteases equilibrium. Finally, further research is needed to clarify the common pathogenesis of the two diseases to optimize their therapeutic management.