Periodontal Infections and Coronary Heart Disease

Spahr, Axel; Klein, Elena; Khuseyinova, Natalie; Boeckh, Clemens; Muche, Rainer; Kunze, Markus; Rothenbacher, Dietrich; Pezeshki, Gita; Hoffmeister, Albrecht; Köenig, Wolfgang

doi:10.1001/archinte.166.5.554

Cited by 217 publications

(67 citation statements)

References 56 publications

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“…Adjustment for increasing age, in particular, influenced the association observed in the univariable analyses. Previous studies have consistently adjusted for age when investigating associations between antibody levels against P. gingivalis and A. actinomycetemcomitans , periodontitis, and CVD [19–23]; our data support the hypothesis that increasing age is an independent risk factor for loss of attachment.…”

Section: Discussionsupporting

confidence: 85%

“…In the present study we have examined the associations between periodontitis, CVD, and concentration of IgG antibodies to P. gingivalis and A. actinomycetemcomitans in a cohort of 576 subjects (Table 1), which is a large cohort in comparison to the existing literature on this topic [9,19–23]. As determinant of periodontitis, we used a mean loss of attachment of at least 2.55 mm [27,37,38].…”

Section: Discussionmentioning

confidence: 99%

“…Also, cross-sectional and case-control studies have reported positive associations between levels of antibodies against A. actinomycetemcomitans and P. gingivalis and the presence of coronary heart disease within large population-based cohorts [21–23]. …”

Section: Introductionmentioning

confidence: 99%

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Immunoglobulin G antibodies againstPorphyromonas gingivalisorAggregatibacter actinomycetemcomitansin cardiovascular disease and periodontitis

Damgaard

Reinholdt

Enevold

et al. 2017

Journal of Oral Microbiology

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Objectives: The aim was to elucidate whether levels of circulating antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis correlate to loss of attachment, as a marker for periodontitis and cardiovascular disease (CVD). Design: Sera were collected from 576 participants of the Danish Health Examination Survey (DANHES). Immunoglobulin G antibodies against lipopolysaccharide (LPS) and protein antigens from the a, b and c serotypes of A. actinomycetemcomitans and P. gingivalis were quantified by titration in ELISA plates coated with a mixture of antigens prepared by disintegration of bacteria. Results: Levels of antibodies against P. gingivalis (OR = 1.48) and A. actinomycetemcomitans (1.31) associated with periodontitis, as determined by univariable logistic regression analysis. These antibody levels also associated with CVD (1.17 and 1.37), respectively, However, after adjusting for other risk factors, including age, smoking, gender, alcohol consumption, overweight, and level of education using multivariable logistic regression analysis, only increasing body mass index (BMI; 1.09), previous smoking (1.99), and increasing age (decades) (2.27) remained associated with CVD. Increased levels of antibodies against P. gingivalis (1.34) remained associated with periodontitis after adjusting for other risk factors. Conclusions: CVD and periodontitis were associated with levels of IgG antibodies to P. gingivalis or A. actinomycetemcomitans in univariable analyses, but only the association of P. gingivalis antibody levels with periodontitis reached statistical significance after adjustment for common confounders. Age, in particular, influenced this relationship.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Immunoglobulin G antibodies againstPorphyromonas gingivalisorAggregatibacter actinomycetemcomitansin cardiovascular disease and periodontitis

Damgaard

Reinholdt

Enevold

et al. 2017

Journal of Oral Microbiology

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“…Many epidemiological studies have found an association between periodontitis and atherosclerosis [2,3,38]. Spahr et al [39] investigated the relationship between coronary heart disease and antibody response to periodontopathic bacteria. They reported that T. denticola, P. gingivalis and Tannerella forsythensis were significantly related to coronary heart disease in smokers.…”

Section: Discussionmentioning

confidence: 99%

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Okuda

Kimizuka

Miyamoto

et al. 2007

Microbes and Infection

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Treponema denticola, a major pathogen of periodontitis, has also been detected in the lesions of atherosclerosis. The aim of this study was to investigate induction of chemokine production in human umbilical vein endothelial cells (HUVECs) by T. denticola and determine whether those chemokines were degraded by a protease, dentilisin. T. denticola ATCC35405 or dentilisin-deficient mutant K1 were added to HUVECs and levels of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in the culture supernatants were determined by enzyme-linked immunosorbent assay. T. denticola ATCC35405 induced production of IL-8 in a time-dependent manner, with both production of IL-8 and expression of IL-8 mRNA showing higher levels than with exposure to dentilisin-deficient mutant K1. Although exposure to ATCC35405 induced expression of MCP-1 mRNA in the HUVECs, MCP-1 levels were remained similar to that in unstimulated cells. IL-8 and MCP-1 showed partial hydrolysis with exposure to T. denticola ATCC35405, but not with T. denticola K1. These results suggest that T. denticola can evade host defense mechanisms by modulating production of IL-8 and MCP-1, and that this play a role in the development of chronic infections such as periodontitis. The association of T. denticola infection to atherosclerosis was also discussed based on the present study.-3 -

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“…The role of periodontal disease in systemic conditions including cardiovascular diseases and diabetes mellitus is well known [3][4][5][6][7][8] but the exact role of periodontal disease in renal disease is not clear. Periodontal disease has been found to be moderate to severe in renal failure patients [9][10][11][12] but there are few contradictory findings.…”

mentioning

confidence: 99%

Periodontal Status of Patients Undergoing Hemodialysis Therapy in a Tertiary Level Hospital of Nepal

Rana¹,

Sharma²

2017

Med. J. Shree Birendra Hosp.

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Introduction: Periodontitis is a chronic inflammation of the supporting structures of the teeth. It has been shown to be associated with systemic diseases including cardiovascular and respiratory diseases, diabetes mellitus and preterm birth. Conflicting reports on the relationship of chronic renal failure patients and periodontal diseases are present in the literature. No previous study has been reported in renal patients in Nepalese population. Hence this study was done to assess the oral hygiene and periodontal conditions in hemodialysis patients in a Tertiary level hospital in Nepal.Methods: Descriptive observational study in which hemodialysis cases were assessed for periodontal parameters including Oral Hygiene- Simplified Index (OHI-S), Plaque Index (PI), Gingival Index (GI), Probing pocket depth (PPD) and clinical attachment level (CAL).Results: A total of 30 patients (20 male, 10 female; mean age 51.06±14.37 years) were assessed. Mean OHI-S, PI, GI, PPD and CAL were 4.02±0.89, 1.93±0.27, 1.57±0.28, 2.09±0.19 and 2.18±0.42, respectively. The distribution of periodontitis was 10% severe, 46.66% moderate and 43.33% mild periodontitis.Conclusions: Hemodialysis patients showed poor oral hygiene and moderate and periodontitis. Hence periodic assessment and periodontal treatment may prevent further complications in these patients.

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Periodontal Infections and Coronary Heart Disease

Cited by 217 publications

References 56 publications

Immunoglobulin G antibodies againstPorphyromonas gingivalisorAggregatibacter actinomycetemcomitansin cardiovascular disease and periodontitis

Immunoglobulin G antibodies againstPorphyromonas gingivalisorAggregatibacter actinomycetemcomitansin cardiovascular disease and periodontitis

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Periodontal Status of Patients Undergoing Hemodialysis Therapy in a Tertiary Level Hospital of Nepal

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