Periodontal infections and pre‐term low birth weight: a case‐control study

Buduneli, Nurcan; Baylas, Haluk; Buduneli, Eralp; Türkoğlu, Oya; Köse, Timur; Dahlén, Gunnar

doi:10.1111/j.1600-051x.2005.00670.x

Cited by 146 publications

(163 citation statements)

References 38 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…Subgingival plaque samples were collected as described previously [28] from the two deepest pockets of the dentition. Prior to sampling, the sample teeth were isolated with cotton rolls and the sites were cleaned of saliva and supragingival plaque using sterile cotton pellets.…”

Section: Subgingival Plaque Samplingmentioning

confidence: 99%

Is there an association between obstructive sleep apnea syndrome and periodontal inflammation?

et al. 2015

View full text Add to dashboard Cite

Objectives: To assess salivary, serum biomarkers, and subgingival bacteria as putative candidates in the potential association between obstructive sleep apnea syndrome (OSAS) and periodontal disease. Materials and methods:Fifty-two patients were grouped according to the severity of OSAS: 13 participants served as controls, 17 patients had mild-to-moderate OSAS, and 22 severe OSAS. Serum, saliva, and subgingival plaque samples were collected, clinical periodontal parameters recorded. Salivary, serum concentrations of interleukin-6 (IL-6), tumour necrosis factor (TNF-α), osteoprotegerin, sRANKL, and apelin were analysed by enzyme-linked immunosorbent assay. Bacterial counts were determined by real-time QPCR on plaque microbial DNA preparations.Results: There was a significant change in the composition of microbes in plaque particularly in severe OSAS samples (p<0.01). Statistical analyses indicated significantly higher salivary IL-6 levels in both OSAS groups compared to controls (p<0.05). Salivary apelin levels were significantly higher in Serum levels of these biomarkers and salivary osteoprotegerin, sRANKL levels were similar in the study groups. The incidence and duration of apnea positively correlated with clinical periodontal parameters (p<0.05). Conclusion:OSAS appeared to alter the tested bacteria in plaque, correlate with increasing periodontal disease severity, have additive effect on salivary IL-6.Clinical relevance: OSAS is likely to interact with periodontal disease.

show abstract

Section: Subgingival Plaque Samplingmentioning

confidence: 99%

Is there an association between obstructive sleep apnea syndrome and periodontal inflammation?

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Preeclampsia also involves increase in inflammatory cytokines in the blood stream, which makes adjusting for preeclampsia in our study important before any conclusion can be made. On the other hand, many studies did not find a positive correlation between periodontal disease and preterm labor [28][29][30][31][32]. Based on these results they do not support a specific drive to improve periodontal health of pregnant women as a means of improving pregnancy outcomes [28].…”

Section: Discussionmentioning

confidence: 80%

Periodontal Disease and Preterm Birth, is There any Relationship?

Kawar¹,

Partovi²

2016

J Interdiscipl Med Dent Sci

View full text Add to dashboard Cite

Aim: Prematurity and low birth weight are major causes of neonatal morbidity, mortality and long-term disability. The purpose of this study was to determine if an association exists between periodontal disease and preterm birth (PT).Material and methods: 59 females from the delivery ward at St. Mary's Health Center, St. Louis, MO. Group I had 29 women who had Preterm birth (PT). Group II had 30 women whose babies were born full term (T). Full-mouth periodontal examination performed. Data collected about risk factors: race, maternal age, pregnancy complications; infections/inflammation; number of previous pregnancies and chemical abuse. Mothers were considered to have moderate to severe periodontal disease if ≥ 10% of sites measured ≥ 5 mm probing depth. Nominal logistic regression analysis used to calculate the odds of having a preterm birth infant having moderate to severe periodontal disease while adjusting for other risk factors.Results: After adjustment for smoking, preeclampsia, and infections/inflammation other than periodontitis, a statistically significant association was found between preterm birth and moderate to severe periodontitis (odds ratio = 5.8, 95% CI = 1.2-37.5, p = 0.04). Conclusion:Moderate to severe periodontal disease may be an independent risk factor for preterm birth.

show abstract

“…A study conducted by Buduneli N. et al (2005) showed results of high levels of P. micros and C. rectus in mothers delivering LBW infants [19]. A study from a cohort of young minority women in New York, have found that PLBW mothers had significantly higher levels of T. forsythensis and C. rectus, although clinical periodontal status revealed no significant differences between the two groups [13].…”

Section: Discussionmentioning

confidence: 99%

Effect of Periodontal Infection on Birth Weight of Infants: A Clinical and Microbiological Study*

Kothiwale¹,

Gandhi²

2013

OJMM

View full text Add to dashboard Cite

Background: Maternal periodontal infection has been proposed to influence pre-term delivery and low birth weight infants through mechanisms involving inflammatory mediators or direct bacterial assault on the amnion. Thus, the aim of the present study was to assess the presence of periodontal pathogens in maternal periodontal infection and their effect on the birth weight of infants. Materials and Methods: The case-control study included 30 mothers with a singleton gestation and gestational age of >37 weeks. Data regarding the periodontal status, pregnancy outcome variables, hemoglobin levels (Hb%) and other factors that may influence adverse pregnancy outcomes were collected. A qualitative analysis of the predominant anaerobic organisms was conducted. The data was analysed using one-way ANOVA test and Scheffe's test. Results: The microbiological results showed that prevalent colonies of organisms isolated from the experimental groups were of Bacteroides spp. (n = 3), Fusobacterium spp. (n = 3) and Peptostreptococcus spp. (n = 9). In the control group, Peptostreptococcus spp. (n = 15) were predominant. In the experimental group, it was seen that Bacteroides spp. (p = 0.003) and Fusobacterium spp. (p = 0.050) were statistically significant with the birth weight of the infant. The one-way ANOVA test showed that the birth weight of the infant was inversely proportionate with increase in severity of the periodontal disease. Scheffe's test showed that presence of a periodontal pocket showed most significance to the birth weight of an infant as compared to presence of local factors or bleeding on probing. Conclusion: The study revealed that the gram negative organisms, Bacteroides spp. and Fusobacterium spp. were significantly associated with the low birth weight (LBW) of the infants, although there was not a significant difference in the clinical periodontal status between the experimental groups and the controls. It could be proposed that specific groups of pathogens may have a contributory role in the risk of LBW.

show abstract

Periodontal infections and pre‐term low birth weight: a case‐control study

Cited by 146 publications

References 38 publications

Is there an association between obstructive sleep apnea syndrome and periodontal inflammation?

Is there an association between obstructive sleep apnea syndrome and periodontal inflammation?

Periodontal Disease and Preterm Birth, is There any Relationship?

Effect of Periodontal Infection on Birth Weight of Infants: A Clinical and Microbiological Study*

Contact Info

Product

Resources

About