Periodontal Inflammation as Risk Factor for Pancreatic Diseases

Milašin, Jelena; Jakoba, Natasa Nikolic; Stefanovic, Dejan; Sopta, Jelena; Pucar, Ana; Lekovic, Vojislav; Kenney, Barrie E.

doi:10.5772/25711

Cited by 5 publications

(7 citation statements)

References 58 publications

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“…11,12 In a recent study, bone loss, a clinical sign of chronic periodontitis was indicated as an independent risk factor for the development of cancer in the oral cavity. 13 The research concentrated on the different types of cancer , their association with the inflammation and the pathophysiological mechanisms behind malignant cellular transformation. 14,15 A key factor in inflammation linked with cancer is NF-κb transcription factor, a basic regulator of the innate inflammation and immunity through an activated expression of inflammatory biomarkers namely cytokines, chemokines, adhesion molecules, proteolytic enzymes, angiogenic factors and a wide spectrum of toxic metabolic cellular substances.…”

Section: The Relationship Between Chronic and Oral Cancer Periodontitismentioning

confidence: 99%

“…The human papilloma virus is linked with cancer of the cervix, vulva, penis, and anus. 3,13,[22][23][24][25][26] It has been suggested that herpes viruses might impair local host defense by disrupting the protective epithelial barrier by lysing the epithelial cells, or by altering the expression of cell surface receptor molecules. Human papilloma viruses, cause characteristic cytopathic effects (koilocytosis), a proliferation of epithelial cells.…”

Section: Cacteria and Viruses In Associated Cancermentioning

confidence: 99%

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Periodontitis as a risk factor for cancer

Dinachandran¹,

Padmakumar²,

Pillai³

et al. 2022

IJPI

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Periodontitis is a chronic infection caused by inflammatory reactions in response to microorganism in endogenous dental plaque. The condition is characterized by epithelial proliferation and migration, release of inflammatory cytokines, chemokines, prostaglandins, growth factor and enzymes all of which are closely associated with carcinogens. The link between periodontitis and systemic diseases has been examined since long, and there has been a notable increase in the interest in understanding the possible association with cancer. Aim of this review article is to review the published literature regarding chronic periodontitis as a risk factor for oral cancer. Relevant published studies were selected which states that chronic infection such as periodontitis can play a direct/indirect role in carcinogenesis.

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Section: The Relationship Between Chronic and Oral Cancer Periodontitismentioning

confidence: 99%

Section: Cacteria and Viruses In Associated Cancermentioning

confidence: 99%

Periodontitis as a risk factor for cancer

Dinachandran¹,

Padmakumar²,

Pillai³

et al. 2022

IJPI

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“…The role of the common genetic risk factors between the two situations, however, remains unclear. The sensitivity to the disease could be influenced by predetermined factors such as genetic polymorphisms that also need to be investigated [35,36]. Another possible mechanism could be attributed to the large inflammatory load caused by the PD and could be associated with the risk of LC through the mechanisms that are involved and lead to oxidative stress that causes damage to the tissues.…”

Section: Editorialmentioning

confidence: 99%

The Specific Role of Periodontal Disease in Lung Cancer Pathogenesis

Chrysanthakopoulos¹

2018

MADOHC

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“…Molecular mechanisms -Tumor-infiltrating leucocytes as well as cytokine related signaling pathways are critical components in the development of the inflammatory tumor microenvironment. e.g peroxynitrite, an inflammatory metabolite acts as a direct mutagenic agent (21,22). Persistent inflammatory state maintains and promotes cancer progression via tumor tissue remodeling, angiogenesis, metastasis and the suppression of the innate anticancer immune response to reach full malignancy (23).…”

Section: Chronic Inflammation and Carcinogenesis -General Aspectsmentioning

confidence: 99%

“…Many case reports documenting gingival squamous cell carcinoma mimicking to severe localized periodontal disease showing similar symptoms of swelling, bleeding, tooth mobility, deep periodontal pockets, and bone destruction have been reported ,emphasizing a closer clinical examination and early detection of the lesion for early management (72)(73)(74)(75). Rather, cases of other types of cancers mistaken for periodontal disease such as metastatic pancreatic cancer and osteogenic sarcoma have also been reported in literature (76).…”

Section: Periodontal Inflammation -Prespectives In Carcinogenesismentioning

confidence: 99%

Chronic Inflammation and Carcinogenesis – Emerging Role of Chronic Inflammatory Periodontal Disease

Grover¹,

Kapoor²,

Sehgal³

et al. 2016

Cancer Res Front

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With exponential increase in the number of cases of cancers worldwide in recent past, it is imperative to enhance our understanding about the etiologic and risk factors associated with this seriously morbid condition. Increasing attention has been focussed on chronic infections and inflammatory diseases, implicating a role in carcinogenesis, particularly in developing countries. Periodontal disease is a bacterially induced chronic inflammatory process that affects tooth supporting connective tissue and alveolar bone in the oral cavity, potentially leading to tooth loss. The concept of these diseases as localized entities affecting only the teeth and supporting apparatus has been revised lately, in the light of mounting evidence of periodontal infection's influence on chronic inflammatory disease states. Periodontal disease has been linked to several systemic conditions like cardiovascular diseases, diabetes mellitus, adverse pregnancy outcomes, obesity and cancers, yet underlying mechanisms are still elucidating. The focus of this review article will be an in depth discussion of the role of chronic inflammation, particularly chronic periodontal inflammation in causation or association of human cancers and discussion of possible biological mechanisms involved.

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Periodontal Inflammation as Risk Factor for Pancreatic Diseases

Cited by 5 publications

References 58 publications

Periodontitis as a risk factor for cancer

Periodontitis as a risk factor for cancer

The Specific Role of Periodontal Disease in Lung Cancer Pathogenesis

Chronic Inflammation and Carcinogenesis – Emerging Role of Chronic Inflammatory Periodontal Disease

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