Periodontal Inflammatory Burden and Salivary Matrix Metalloproteinase‐8 Concentration Among Patients With Chronic Kidney Disease at the Predialysis Stage

Nylund, Karita; Meurman, Jukka H.; Heikkinen, Anna Maria; Honkanen, Eero; Vesterinen, Maarit; Furuholm, Jussi; Tervahartiala, Taina; Sorsa, Timo; Ruokonen, Hellevi

doi:10.1902/jop.2015.150285

Cited by 17 publications

(25 citation statements)

References 43 publications

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“…In the authors’ previous study, increased salivary MMP‐8 concentration was associated with poor oral health with emphasis on periodontitis at the predialysis stage of the same patient group as discussed here . Elevated salivary MMP‐8 concentrations were associated with at least two sites with ≥6 mm PD compared with zero to one sites with 6 mm or deeper pockets and with higher PIBI and higher TDI scores …”

Section: Discussionmentioning

confidence: 64%

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Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation in kidney disease

Nylund

Ruokonen

Sorsa

et al. 2018

Journal of Periodontology

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Section: Discussionmentioning

confidence: 64%

“…Salivary MMP‐8 was analyzed by time‐resolved IFMA using monoclonal MMP‐8–specific antibodies as catching and tracing antibodies, respectively . The tracer antibody was labeled with europium‐chelate as detailed earlier …”

Section: Methodsmentioning

confidence: 99%

Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation in kidney disease

Nylund

Ruokonen

Sorsa

et al. 2018

Journal of Periodontology

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“…Table describes the characteristics of 7 case‐control studies and 38 cross‐sectional studies on the non‐directional association, and lists them in reverse publication order . Among them, 24 had a statistical analysis, but 7 did not consider any confounding factors (Appendix A) .…”

Section: Resultsmentioning

confidence: 99%

The directional and non‐directional associations of periodontitis with chronic kidney disease: A systematic review and meta‐analysis of observational studies

Zhao

Khawaja

Jin

et al. 2018

J of Periodontal Research

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This systematic review aimed to assess the current evidence on the directional and non-directional associations of periodontitis with chronic kidney disease (CKD). Electronic search for observational studies on the association of periodontitis with CKD was performed in MEDLINE, EMBASE, PubMed, Open GREY and Cochrane library up to June 5, 2017. Two reviewers conducted study selection, data collection and assessment of methodological quality using the original and modified Newcastle-Ottawa Scale. Cohort, case-control and cross-sectional studies were included, which clearly defined periodontitis and CKD or reported acceptable clinical parameters of these 2 diseases in adults. Meta-analysis was employed to estimate the pooled odds ratio on the non-directional association and the incidence rate ratio (IRR) for the directional association. Among 2530 potential eligible articles, 47 were finally included. Most of them investigated a non-directional association of periodontitis with CKD, including 7 case-control studies and 38 cross-sectional studies; 24 studies had statistical analysis on the non-directional association and 75% of them reported significant results, which were supported further by the meta-analysis (random: odds ratio = 2.12, P < .001; χ = 25.74, I = 88.3%). None of the studies focused on the directional association of CKD (as the exposure) with periodontitis (as the outcome), whereas 2 retrospective cohort studies explored a directional association of periodontitis (as the exposure) with CKD (as the outcome) (random: IRR=2.10, P > .05; fixed: IRR=1.76, P < .05; χ = 4.65, I = 78.3%). Overall, the high heterogeneity of studies limits the significance of these results. There is substantial evidence on the non-directional association of periodontitis with CKD, while there are limited studies on the directional association. Well-designed prospective studies with longer follow-ups in representative communities are needed to clarify the directional association and enhance the quality of the evidence on this topic.

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“…MMP-8 was analyzed by time-resolved immunofluorometric assay (IFMA) [14,30,[31][32][33]. The monoclonal MMP-8-specific antibodies (8708 and 8706, Medix Biochemica, Espoo, Finland) were used as catching antibody and a tracer antibody.…”

Section: Analysis Of Mmp-8 Timp-1 and Il-6mentioning

confidence: 99%

Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status

et al. 2018

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Elevated serum concentrations of MMP-8 and IL-6 in CRA patients reflected chronic RA, while elevated salivary concentrations of MMP-8 levels in ERA patients reflected increased periodontal inflammation. Key messages Concentrations of inflammatory biomarkers in serum and saliva were different between patients with RA and healthy controls. Concentrations of MMP-8 and of IL-6 in serum were elevated in patients with chronic RA reflecting joint inflammation and the burden of established RA. Concentrations of MMP-8 in saliva was elevated already at the early stage of RA and the level of salivary MMP-8 was associated with poor periodontal health both in patients with early and in those with chronic RA.

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Periodontal Inflammatory Burden and Salivary Matrix Metalloproteinase‐8 Concentration Among Patients With Chronic Kidney Disease at the Predialysis Stage

Abstract: Elevated salivary MMP-8 associated significantly with more severe oral/periodontal inflammatory burden among patients with CKD at the predialysis stage. Thus, salivary MMP-8 analysis could give adjunctive information regarding oral health.

Cited by 17 publications

References 43 publications

Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation in kidney disease

Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation in kidney disease

The directional and non‐directional associations of periodontitis with chronic kidney disease: A systematic review and meta‐analysis of observational studies

Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status

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