Periodontal medicine: work in progress!

Loos, Bruno G.

doi:10.1111/jcpe.12550

Cited by 30 publications

(25 citation statements)

References 12 publications

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“…Research activity has grown continuously since the late 1980s with about one third of all recent periodontal studies now dealing with the relationship between periodontal disease and systemic disease [ 1 •]. Further to this, a total of 57 different systemic disease conditions are now being researched in relation to periodontal diseases [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…The review is focused on systemic diseases or conditions that could impact the development or progression of periodontitis. Given the constraints of the large number of possible candidates [ 2 ], we have limited the focus of this review to diabetes, metabolic syndrome and obesity as they have been suggested to have a causative role in periodontitis. Discussion of the biological mechanisms through which these exemplars could increase the risk of periodontitis is beyond the scope of this review.…”

Section: Introductionmentioning

confidence: 99%

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Periodontitis and Systemic Disease: Association or Causality?

Winning

Linden

2017

Curr Oral Health Rep

118

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Purpose of ReviewThe aim was to assess recent evidence that diabetes, metabolic syndrome (MetS) and obesity impact the progression of periodontitis.Recent FindingsElectronic searches using Embase, Medline, and Web of Science were carried out for epidemiological studies on humans, published between 2014 and 2016. A small number of prospective studies and systematic reviews were identified that in general provide further support for the hypothesis that diabetes, metabolic syndrome and obesity can adversely affect the periodontal condition.SummaryConfounding remains the most challenging issue in the interpretation of the associations found between diabetes, MetS, obesity and periodontal disease. Recent research applying a Mendelian randomisation approach concluded that the association between obesity and periodontitis is confounded and questioned a role for obesity in causation. Further studies are warranted to assess the issue of causality.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Periodontitis and Systemic Disease: Association or Causality?

Winning

Linden

2017

Curr Oral Health Rep

118

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“…Severe periodontitis occurs in 8.9% of the US adult population and is particularly prevalent in impoverished and marginalized communities . Periodontitis has also been associated with at least 57 medical diseases and disabilities . The association between periodontitis and systemic morbidity may be the result of periodontal herpesviruses entering the systemic circulation and infecting distant body sites …”

Section: Introductionmentioning

confidence: 99%

Periodontal herpesvirus morbidity and treatment

Slots

2019

Periodontology 2000

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Four billion individuals worldwide have a history of periodontitis, with the poorest people in society most affected. Periodontitis can lead to unsightly drifting of teeth and tooth loss that may interfere with the wellbeing of daily living and has also been linked to at least 57 medical diseases and disabilities. The etiology of severe periodontitis includes active herpesviruses, specific bacterial pathogens, and destructive immune responses, but herpesviruses seem to be the major pathogenic determinant. Periodontal herpesviruses that disseminate via the systemic circulation to nonoral sites may represent a major link between periodontitis and systemic diseases. Current treatment of periodontitis focuses almost exclusively on bacterial biofilm and will require revision. Periodontal therapy that targets both herpesviruses and bacterial pathogens can provide long‐term clinical improvement and potentially reduces the risk of systemic diseases. Molecular diagnostic tests for periodontal pathogens may enable early microbial identification and preemptive therapy. This review details an efficient and reliable anti‐infective treatment of severe periodontitis that can be carried out in minimal time with minimal cost.

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“…There is evidence in both the human and veterinary literature of an association between periodontal disease and systemic diseases. In humans, 57 systemic conditions are being researched in connection to periodontal disease; most of which are the result of chronic inflammatory disease [14], including cardiovascular diseases such as atherosclerosis, stroke and coronary heart disease [1, 16,], endocarditis [8], rheumatoid arthritis [2, 4, 5,], diabetes [6,26] and pregnancy complications such as preeclampsia [3,21], low birth weight [9] and premature delivery [28].…”

Section: Introductionmentioning

confidence: 99%

Periodontal Disease in Association with Systemic Diseases in the Dog

Penlington

Faixová

2019

Folia Veterinaria

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Periodontal disease (PD) is the second most common disease affecting dogs in UK veterinary practices. Veterinary and human literature suggests that periodontal disease may be associated with bacteraemia and a chronic, systemic release of inflammatory mediators which produce direct or immune-mediated changes elsewhere in the body. Thirty canine periodontal patient’s electronic medical histories were analysed for comorbidities. The findings were analysed overall to identify any possible associations. Seventy three percent of these dogs had comorbidities, most commonly haematopoietic, cardiovascular, musculoskeletal and hepatic systems were involved. The most prevalent comorbidities were: high liver enzymes, heart murmur, mitral valve disease, and monocytosis. Other interesting comorbidities were: endocarditis, neutrophilia, submandibular lymph node enlargement and arthritis. Periodontal disease patients had a higher prevalence of disease when compared to the disease prevalence data for UK pet dogs in general. Mitral valve disease was over 17 times more likely in the periodontal disease patients. Comorbidity disease prevalence also increased with more severe periodontal disease stages. This study supports an association between periodontal disease and systemic diseases in the dog. Further studies should focus on confirming a cause and effect relationship. Until then, these data may be useful for veterinarians to examine periodontal patients for concurrent diseases and can be used as a tool to promote dental disease prevention to pet owners.

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Periodontal medicine: work in progress!

Cited by 30 publications

References 12 publications

Periodontitis and Systemic Disease: Association or Causality?

Periodontitis and Systemic Disease: Association or Causality?

Periodontal herpesvirus morbidity and treatment

Periodontal Disease in Association with Systemic Diseases in the Dog

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