The purpose of this article is to do a three-dimensional finite element stress analysis, in relation to root form implant supported by overdenture attachment, during axial and non-axial loading. Two porous coated Titanium-aluminum-vanadium (Ti-6Al-4V) implants with overdenture abutment were embedded in both simple and 3D model of interforaminal region of mandible. The material properties of tissue ingrowth bonded interface were calculated considering Iso-Strain condition. The masticatory forces: axial load of 35 N, a horizontal load of 10 N, and an oblique load of 120 N, was applied for the two qualities of cancellous bone. It implied that porous topography of the implant led to optimal stress transfer at the tissue ingrowth bonded interface and insignificant punching stress at the apex than a smooth surface implant. The inferior bone quality was deformed even under physiologic loads and showed wider stress pattern. Simulated implant abutment to implant bone interface stress may be significantly affected by the quality of the bone and the surface topography of the implant. The interface is affected to a lesser extent by the prosthetic material properties. Threedimensional anatomical model was more close to reality than the geometry of much simpler altered models.