Periodontal Pathogens in the Etiology of Pancreatic Cancer

Öğrendik, Mesut

doi:10.1159/000452708

Cited by 53 publications

(41 citation statements)

References 12 publications

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“…Oral pathogens and inflammation (periodontitis) have been linked to increased risk for PC, mainly through association studies with pancreatic cancer incidence and salivary microbiota composition or seroprevalence of Porphyromonas gingivalis antibodies 27–30. Specifically, oral carriage of P. gingivalis , and Aggregatibacter actinomycetemcomitans , as well as circulating antibodies against P. gingivalis were associated with a higher risk of PC.…”

Section: Discussionmentioning

confidence: 99%

Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer

Gaiser

Halimi

Alkharaan

et al. 2019

Gut

171

158

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ObjectivesIntraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that can progress to invasive pancreatic cancer. Associations between oncogenesis and oral microbiome alterations have been reported. This study aims to investigate a potential intracystic pancreatic microbiome in a pancreatic cystic neoplasm (PCN) surgery patient cohort.DesignPaired cyst fluid and plasma were collected at pancreatic surgery from patients with suspected PCN (n=105). Quantitative and qualitative assessment of bacterial DNA by qPCR, PacBio sequencing (n=35), and interleukin (IL)-1β quantification was performed. The data were correlated to diagnosis, lesion severity and clinical and laboratory profile, including proton-pump inhibitor (PPI) usage and history of invasive endoscopy procedures.ResultsIntracystic bacterial 16S DNA copy number and IL-1β protein quantity were significantly higher in IPMN with high-grade dysplasia and IPMN with cancer compared with non-IPMN PCNs. Despite high interpersonal variation of intracystic microbiota composition, bacterial network and linear discriminant analysis effect size analyses demonstrated co-occurrence and enrichment of oral bacterial taxa including Fusobacterium nucleatum and Granulicatella adiacens in cyst fluid from IPMN with high-grade dysplasia. The elevated intracystic bacterial DNA is associated with, but not limited to, prior exposure to invasive endoscopic procedures, and is independent from use of PPI and antibiotics.ConclusionsCollectively, these findings warrant further investigation into the role of oral bacteria in cystic precursors to pancreatic cancer and have added values on the aetiopathology as well as the management of pancreatic cysts.

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Section: Discussionmentioning

confidence: 99%

Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer

Gaiser

Halimi

Alkharaan

et al. 2019

Gut

171

158

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“…A statistically significant association between squamous cell carcinoma of the head and neck and periodontal disease has also been reported, suggesting that periodontal disease may be an independent risk factor, with practical implications for prevention, early diagnosis, and treatment, in the search for a possible improvement in the prognosis of the disease. Understanding host-microbe interaction and related cause-effect mechanisms has paved the way for a broader understanding of the role of the microbiome in health and disease conditions, providing new therapeutic approaches in clinical practice [47][48][49][50][51][52][53].…”

Section: Oncologymentioning

confidence: 99%

Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review

et al. 2019

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In recent scientific literature, oral infections and systemic manifestations, or correlations between oral health and systemic diseases are a topic of discussion. Porphyromonas gingivalis is one of the bacteria implicated in the biofilm formation of bacterial plaque, and plays an important role in the progression of periodontal disease. In this systematic review authors have evaluated the literature of the last 10 years on P. gingivalis and all the systemic implications proven. This study therefore evaluates all the districts of the organism in which this bacterium may have implications. From the results it emerges that P. gingivalis has implications in the onset of different systemic pathologies, including rheumatoid arthritis, cardiovascular pathologies, and neurodegenerative pathologies. Surely, understanding the mechanisms of diffusion of this bacterium, it would be possible to prevent a series of pathologies. Thus, putting the dentist clinician at the center of prevention for these diseases.

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“…forsythia expresses two sialidases, SiaHI and NanH, which are important in bacterial colonization [11]. Oral microbiome composition alters fatty acid metabolism [12] and are not just associated with oral cancer development [13] but also are suspected of promoting esophageal [14,15], pancreatic cancer [16,17], or liver cancer [18]. T. forsythia "contributes to the growth of a partner species, Fusobacterium nucleatum, in co-biofilms" [19].…”

Section: Microbiome (Tab 1)mentioning

confidence: 99%

Microbiome and morbid obesity increase pathogenic stimulus diversity

Brücher

Jamall

2019

4open

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The microbiome, the relationship between environmental factors, a high-fat diet, morbid obesity, and host response have been associated with cancer, only a small fraction of which (<10%) are genetically triggered. This nongenetic association is underpinned by a worldwide increase in morbid obesity, which is associated with both insulin resistance and chronic inflammation. The connection of the microbiome and morbid obesity is reinforced by an approximate shift of about 47% in the estimated total number of bacteria and an increase from 38,000,000,000,000 in a reference man to 56,000,000,000,000 in morbid obesity leading to a disruption of the microbial ecology within the gut. Humans contain 6,000,000,000 microbes and more than 90% of the cells of the human body are microorganisms. Changes in the microflora of the gut are associated with the polarization of ion channels by butyrate, thereby influencing cell growth. The decrease in the relative proportion of Bacteroidetes together with a change in the fermentation of carbohydrates by bacteria is observed in morbid obesity. The disruption of homeostasis of the microflora in the obese changes signaling and crosstalk of several pathways, resulting in inflammation while suppressing apoptosis. The interactions between the microbiome and morbid obesity are important to understand signaling and crosstalk in the context of the progression of the six-step sequence of carcinogenesis. This disruption of homeostasis increases remodeling of the extracellular matrix and fibrosis followed by the none-resolvable precancerous niche as the internal pathogenic stimuli continue. The chronic stress explains why under such circumstances there is a greater proclivity for normal cells to undergo the transition to cancer cells.

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Periodontal Pathogens in the Etiology of Pancreatic Cancer

Cited by 53 publications

References 12 publications

Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer

Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer

Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review

Microbiome and morbid obesity increase pathogenic stimulus diversity

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