Periodontal plastic surgery for treatment of localized gingival recessions: a systematic review

Roccuzzo, Mario; Bunino, Marco; Needleman, Ian; Sanz, Mariano

doi:10.1034/j.1600-051x.29.s3.11.x

Cited by 386 publications

(447 citation statements)

References 73 publications

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“…However, for these systems, the periodontal milieu often poses the major problem that the required period of drug exposure (7-10 days) cannot be achieved [11]. Also in the field of periodontal surgery, as in the transplantation of a mucous membrane [12], resorbability of the scaffold material is important to avoid inflammatory effects and surgical removal. Therefore, the use of films or membranes represents a promising approach in periodontal treatment to promote tissue regeneration by avoiding migration of epithelial cells into the periodontal pocket and incorporating antibiotics to inhibit the related bacteria growth [13].…”

Section: Introductionmentioning

confidence: 99%

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

et al. 2015

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Article:Gentile, P., Frongia, M.E., Redon, M.C. et al. (4 more authors) (2015) Functionalised nanoscale coatings using Layer-by-Layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces. Acta Biomaterialia.https://doi.org/10.1016/j.actbio.2015.04.009 eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractIn order to achieve high local biological activity and reduce the risk of side effects of antibiotics in the treatment of periodontal and bone infections, a localised and temporally controlled delivery system is desirable. The aim of this research was to develop a functionalised and resorbable surface to contact soft tissues to improve the antibacterial behaviour during the first week after its implantation in the treatment of periodontal and bone infections. Solvent-cast poly(D,L-lactide-coglycolide acid) (PLGA) films were aminolysed and then modified by Layer-by-Layer technique to obtain a nano-layered coating using poly(sodium4-styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) as polyelectrolytes. The water-soluble antibiotic, metronidazole (MET), was incorporated from the ninth layer. Infrared spectroscopy showed that the PSS and PAH absorption bands increased with the layer number. The contact angle values had a regular alternate behaviour from the ninth layer. X-Ray Photoelectron Spectroscopy evidenced two distinct peaks, N 1s and S 2p , indicating PAH and PSS had been introduced. Atomic Force Microscopy showed the presence of polyelectrolytes on the surface with a measured roughness about 10 nm after 20 layers deposition.The drug release was monitored by Ultraviolet-visible spectroscopy showing 80% loaded-drug delivery in 14 days. Finally, the biocompatibility was evaluated in vitro with L929 mouse fibroblasts and the antibacterial properties were demonstrated successfully against the keystone periodontal bacteria Porphyromonas gingivalis, which has an influence on implant failure, without compromising in vitro biocompatibility. In this study, PLGA was successfully modified to obtain a localised and temporally controlled drug delivery system, demonstrating the potential value of LbL as a coating technology for the manufacture of me...

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Section: Introductionmentioning

confidence: 99%

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

et al. 2015

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“…In suitable cases a combination of the subepithelial connective tissue graft with a coronally advanced pedicle flap is considered to be the gold standard procedure due to the high success rates reported in the literature. 33,37 …”

Section: Discussionmentioning

confidence: 99%

“…25 When the subepithelial connective tissue graft is compared with guided tissue regeneration, the subepithelial graft has shown evidence of achieving greater root coverage. 22,33,34 Evidence shows that the size of the initial recession defect will determine the amount of root coverage achieved. 22 Miller class I defects can achieve complete root coverage in 100% of cases and in class II defects complete root coverage was seen in 88% of cases.…”

Section: Prognosismentioning

confidence: 99%

Gingival recession: part 3. Surgical management using free grafts and guided tissue regeneration

Patel

Nixon²,

Chan

2011

Br Dent J

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“…23 Achieving full root coverage following a single periodontal plastic surgical procedure is difficult and success is often considered to be any decrease in amount of exposed root surface (Fig. 1g) ie an increase in gingival height from the mucogingival line to the gingival margin.…”

Section: Prognosismentioning

confidence: 99%

Gingival recession: part 2. Surgical management using pedicle grafts

Patel

Nixon²,

Chan

2011

Br Dent J

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Periodontal plastic surgery for treatment of localized gingival recessions: a systematic review

Cited by 386 publications

References 73 publications

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

Gingival recession: part 3. Surgical management using free grafts and guided tissue regeneration

Gingival recession: part 2. Surgical management using pedicle grafts

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