The base of systematic reviews available for gingival recession treatment, the use of CAF alone or in association with allogeneic, xenogeneic, or alloplastic biomaterials (e.g., matrix grafts or enamel matrix derivative) has been described as being less painful and more comfortable, due to the need of only one surgical site [ 1 -7 ]. Conversely, it has been demonstrated that use of SCTG, FGG, and nonabsorbable membranes has been associated with increased morbidity and some complications, such as postoperative pain, bleeding and swelling during the early phase of healing (Fig. 4.1a-c ), and membrane exposure/contamination [ 1 -7 ].For instance, in a large practice-based study [ 8 ] considering the use of free gingival grafts (FGGs), subepithelial connective tissue grafts (SCTGs), and acellular dermal matrix grafts (ADMGs) for Class I and II root coverage, moderate to severe pain and swelling were the most signifi cant adverse events, but less than 6 % of the sample experienced moderate or severe bleeding, and all of them were associated with the use of autogenous grafts [ 8 ]. The use of FGG was reported as the most painful procedure, followed by SCTG and ADMG. Additionally, longer chair-time procedures were straight associated to postoperative discomfort, such as pain and swelling, as well as the rate of pain and bleeding where superior for FGG than for SCTG [ 8 ]. On the other hand, it should be also noted that the incidence of infection (less than 1 %), bleeding (3.0 %), swelling (5.4 %), and pain (18.6 %) after the use of SCTG can be considered low to moderate [ 9 ].