Periodontal Status and Metabolic Syndrome in Middle‐Aged Japanese

Fukui, Nao; Shimazaki, Yoshihiro; Shinagawa, Takashi; Yamashita, Yoshihisa

doi:10.1902/jop.2012.110605

Cited by 63 publications

(88 citation statements)

References 49 publications

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“…Epidemiological studies, which have reported an association between periodontitis and MetS have been cross-sectional in nature and cannot identify the direction of any effect (Shimazaki et al 2007, Kushiyama et al 2009, Kwon et al 2011, Fukui et al 2012). In the largest population studied from NHANES III the association with severe periodontitis (two sites with CAL 6 mm) was not significant in the whole sample but only in those aged 45 years .…”

Section: Metabolic Syndrome (Appendix S6)mentioning

confidence: 99%

“…The more accepted criterion of 3 positive components to identify MetS was not used as only 0.8% subjects were affected. Of concern in this and other studies from Japan is the modification of accepted criteria by replacing WC, a measure of abdominal obesity and insulin resistance, with a general measure of adiposity (BMI 25) (Kushiyama et al 2009, Fukui et al 2012) and the use of diabetes as an indicator of glucose intolerance (Shimazaki et al 2007, Kushiyama et al 2009) rather than a confounder in any association.…”

Section: Metabolic Syndrome (Appendix S6)mentioning

confidence: 99%

“…Studies from Japan (Kushiyama et al 2009, Fukui et al 2012, which met the criteria for periodontitis exposure, applied modified criteria for MetS. The strongly increased risk of type 2 diabetes in those with MetS may confound any association with periodontitis.…”

Section: Commentmentioning

confidence: 99%

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Periodontal systemic associations: review of the evidence

Linden

Lyons

Scannapieco

2013

Journal of Periodontology

288

147

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Linden GJ, Lyons A, Scannapieco FA. Periodontal systemic associations: review of the evidence. AbstractAim: To critically appraise recent research into associations between periodontal disease and systemic diseases and conditions specifically respiratory disease, chronic kidney disease, rheumatoid arthritis, cognitive impairment, obesity, metabolic syndrome and cancer. Methods: A MEDLINE literature search of papers published between 2002 and April 2012 was conducted. Studies that included periodontitis as an exposure were identified. Cross-sectional epidemiological investigations on large samples, prospective studies and systematic reviews formed the basis of the narrative review. A threshold set for the identification of periodontitis was used to identify those studies that contributed to the conclusions of the review. Results: Many of the investigations were cross-sectional secondary analyses of existing data sets in particular the NHANES studies. There were a small number of systematic reviews and prospective studies. There was substantial variability in the definitions of exposure to periodontitis. A small number of studies met the threshold set for periodontitis and supported associations; however, in some of the chronic diseases there were no such studies. There was strong evidence from randomized controlled trials that interventions, which improve oral hygiene have positive effects on the prevention of nosocomial pneumonias. Conclusions: There was substantial heterogeneity in the definitions used to identify periodontitis and very few studies met a stringent threshold for periodontitis. Published evidence supports modest associations between periodontitis and some, although not all, of the diseases and conditions reviewed. There is a need to reach a consensus on what constitutes periodontitis for future studies of putative associations with systemic diseases.

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Section: Metabolic Syndrome (Appendix S6)mentioning

confidence: 99%

Section: Metabolic Syndrome (Appendix S6)mentioning

confidence: 99%

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Periodontal systemic associations: review of the evidence

Linden

Lyons

Scannapieco

2013

Journal of Periodontology

288

147

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“…4 It has been discovered that CPD is associated with systemic diseases, such as MetS, [5][6][7] coronary heart disease, 8,9 and CPD is associated with endothelial dysfunction. 10 Because CPD and ED share common risk factors, the epidemiological and pathophysiological linkage between CPD and ED is quite possible.…”

Section: Introductionmentioning

confidence: 99%

Association of ED with chronic periodontal disease

et al. 2013

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To examine the relationship between chronic periodontal disease (CPD) and erectile dysfunction (ED), the interview sheet including the CPD self-checklist (CPD score) and the 5-item version of the International Index of Erectile Function (IIEF-5) was distributed to 300 adult men who received a comprehensive dental examination. Statistical analyses were performed by the Spearman's rank correlation coefficient and other methods. Statistical significance was accepted at the level of P<0.05. The interview sheets were collected from 88 men (response rate 29.3%, 50.9 ± 16.6 years old). There was a statistically significant correlation between the CPD score and the presence of ED (P=0.0415). The results in the present study suggest that ED is related to the damage caused by endothelial dysfunction and the systematic inflammatory changes associated with CPD. The present study also suggests that dental health is important as a preventive medicine for ED.

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“…[1] The metabolic syndrome is also known as Syndrome X, dysmetabolic syndrome, deadly quartet and plurimetabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%