Periodontal status and serum biomarker levels in HFE haemochromatosis patients. A case‐series study

Abstract

Severe periodontitis is associated with the severity of iron burden in patients with HFE-related hereditary haemochromatosis. Dental examination should be included in the initial assessment of all these patients.

Iron overload and periodontal status in patients with sickle cell anaemia: A case series

“…Conversely, serum ferritin level was not associated with any of the outcomes of this study, which corroborates the results reported in previous studies (Boyer et al, 2018; Meuric et al, 2017). Evaluation of serum transferrin saturation and ferritin levels is the least expensive and most widely available method for investigating iron overload.…”

“…These results suggest that patients with SCA and high serum transferrin saturation level are at a higher risk of developing more severe periodontal disease. From this viewpoint, our results corroborate those reported in studies on patients with haemochromatosis (Boyer et al, 2018; Meuric et al, 2017), among which serum transferrin saturation levels of >45% were associated with severe periodontitis. These findings suggest common mechanisms underlying the association between iron overload and periodontitis severity in both conditions (SCA and haemochromatosis).…”

“…Then, information on serum transferrin saturation and ferritin levels was obtained from electronic medical records. Serum transferrin saturation levels of >45% and serum ferritin levels of >1,000 ng/ml were considered high (Antmen et al, 2019; Meuric et al, 2017).…”

“…Although a study reported no association between SCA and periodontal disease (de Carvalho, Thomaz, Alves, & Souza, 2016), we believe that iron overload induced by blood transfusion therapy can be a risk factor for the occurrence and progression of periodontal disease in this population. Moreover, only one clinical study has evaluated the deleterious effects of iron overload on periodontal tissues (Meuric et al, 2017).…”

New growth media for oral bacteria

“…The virulent switch of the microbiota may be influenced by host-related factors such as systemic iron levels. Indeed, a recent study demonstrated that severe periodontitis was associated with the severity of iron burden in patients with HFErelated hereditary haemochromatosis, an autosomal recessive genetic disease leading to iron overload (Meuric et al, 2017b). To further evaluate the impact of iron concentration on the fitness of the oral microbiota, we developed a simplified experimental model with bacterial species for which interactions are known to influence the evolution of periodontal disease, namely Streptococcus gordonii (primary colonizer), Porphyromonas gingivalis and Treponema denticola (anaerobic (Ng et al, 2016).…”