Periodontal status of rheumatoid arthritis patients in khartoum state

Abdelsalam, Safa Kamil; Hashim, Nada Tawfig; Elsalamabi, Emitithal M; Gismalla, Bakri G.

doi:10.1186/1756-0500-4-460

Cited by 16 publications

(14 citation statements)

References 29 publications

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“…It has long been observed that patients with PD are at a higher risk of developing RA [ 3 , 33 ], and patients with RA have increased likelihood of suffering from PD [ 34 , 35 ]. However, the mechanistic basis of this association remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

et al. 2016

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BackgroundIt has been previously hypothesized that oral microbes may be an etiological link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic basis of this association is incompletely understood. Here, we investigated the role of periodontal bacteria in induction of joint inflammation in collagen-induced arthritis (CIA) in B10.RIII mice.MethodsCIA-prone B10.RIII mice were infected orally with a polybacterial mixture of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia for 24 weeks before induction of CIA. The ability of polybacterial mixture to colonize the periodontium and induce systemic response, horizontal alveolar bone resorption in infected B10.RIII mice was investigated. Arthritis incidence, severity of joint inflammation, pannus formation, skeletal damage, hematogenous dissemination of the infection, matrix metalloproteinase 3 (MMP3) levels, and interleukin-17 expression levels were evaluated.ResultsB10.RIII mice had gingival colonization with all three bacteria, higher levels of anti-bacterial immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies, significant alveolar bone resorption, and hematogenous dissemination of P. gingivalis to synovial joints. Infected B10.RIII mice had more severe arthritis, and higher serum matrix metalloproteinase 3 levels and activity. Histopathological analysis showed increased inflammatory cell infiltration, destruction of articular cartilage, erosions, and pannus formation. Additionally, involved joints showed had expression levels of interleukin-17.ConclusionThese findings demonstrate that physical presence of periodontal bacteria in synovial joints of B10.RIII mice with collagen-induced arthritis is associated with arthritis exacerbation, and support the hypothesis that oral bacteria, specifically P. gingivalis, play a significant role in augmenting autoimmune arthritis due to their intravascular dissemination to the joints.Electronic supplementary materialThe online version of this article (doi:10.1186/s13075-016-1056-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

et al. 2016

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“…A high prevalence of periodontal disease was reported in patients with rheumatoid arthritis and some RA patients even experience severe periodontal disease ( 5 - 7 ). Patients with RA also have higher CAL index, more tooth loss and periodontitis ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Periodontitis in rheumatoid arthritis patients, abundance and association with disease activity

Mobini

Maboudi

Tahamtan

2017

Med. J. Islam. Republic Iran

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Background: There are some discrepancy in association between activity of rheumatoid arthritis (RA) and periodontitis. The aim of this study was to evaluate the periodontal status of outpatients with RA. Methods: The study was conducted in 2013-14 in a rheumatology clinic in Sari, north of Iran on 74 patients with RA. Evaluation of RA disease activity was according to disease activity score 28 (DAS28). Periodontitis was evaluated by probing depth (PD), gingival index (GI), clinical attachment level (CAL index), plaque index (PI), and panoramic X-ray. Statistical analysis included independent ttest and Mann-Whitney U test for quantitative, and chi square and OR for qualitative variables and evaluation of RA activity and periodontitis severity. Results: The mean±SD of age and disease duration were 47.01±8.1 and 8.93±8.6 years, respectively and the mean±SD number of teeth was 20.70±6.8. Twenty-seven (36.5%) patients had moderate to severe disease. Forty-seven cases (63.5%) were found with periodontitis and 14 (12.2%) were identified to have moderate to severe periodontitis, unrelated to disease activity (p=0.22). For active/inactive periodontitis OR =1.33 (95% CI: 0.46 - 3.87) was computed. There was no association between RA disease activity and number of teeth, CAL, PI, PD, and GI, (p>0.05). Conclusion: About 60% of RA patients suffered from periodontitis, but there was not any significant relation between RA disease activity and severity of periodontitis. Periodontitis may interfere with management and follow up of RA, so periodic periodontal examination is suggested in these patients.

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“…The study carried out by Abdelsalam et al in 2010 in Sudan [10] indicated a significant relationship between periodontal disease and RA and highlighted the potential for an association between these chronic inflammatory conditions among the Sudanese population.…”

Section: Introductionmentioning

confidence: 99%

Salivary TNFα levels in groups of subjects with rheumatoid arthritis and chronic periodontitis

et al. 2017

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BackgroundRheumatoid arthritis (RA) and chronic periodontitis are the most common chronic inflammatory diseases with significant pathological and clinical similarities. Numerous studies have indicated a relationship between rheumatoid arthritis and periodontal disease. The aim of this study was to compare the TNF-α levels in saliva among patients with Rheumatoid arthritis (RA) and chronic periodontitis as well as healthy subjects.MethodsOne hundred and seventy-one patients were enrolled in this cross-sectional study. Fifty-seven patients diagnosed of RA, 57 patients with chronic periodontitis and 57 healthy subjects. These patients have been examined with regard to TNF-α level from salivary samples. Their teeth were examined with regard to Plaque Index , Gingival Index, probing depth and clinical attachment level.All patients were non-smokers.ResultsThe results revealed a significant difference in all periodontal parameters among the three groups. The chronic periodontitis group showed a significantly higher value in all clinical periodontal parameters in comparison to both the RA and healthy groups. No significant difference was found between salivary TNF-α level among the three study groups.ConclusionsPatients with chronic periodontitis had the highest periodontal indices. However there was no significant difference regarding the level of salivary TNF-α. Hence, suppression of proinflammatory cytokines might prove beneficial in suppressing periodontal diseases among RA patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2341-7) contains supplementary material, which is available to authorized users.

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Periodontal status of rheumatoid arthritis patients in khartoum state

Cited by 16 publications

References 29 publications

Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

Periodontitis in rheumatoid arthritis patients, abundance and association with disease activity

Salivary TNFα levels in groups of subjects with rheumatoid arthritis and chronic periodontitis

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