Periodontal Therapy Effects on Nitrite Related to Oral Bacteria: A 6‐Month Randomized Clinical Trial

Cortelli, Sheila Cavalca; Costa, Fernando Oliveira; Rodrigues, Edson; Cota, Luís Otávio Miranda; Cortelli, José Roberto

doi:10.1902/jop.2015.140678

Cited by 20 publications

(11 citation statements)

References 47 publications

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“…However, the way in which the mechanical procedures are performed seems to influence the results. The studies conducted by our group revealed a decrease in the salivary arginase activity (SAA) after quadrant-wise scaling 11,12 , despite a tendency toward a salivary nitrite increase (also related to the NO cycle) after full-mouth scaling 6 . Mechanical procedures can also be combined with chemical agents for the treatment of gingivitis and periodontitis.…”

Section: Introductionmentioning

confidence: 87%

“…The increased salivary arginase levels 5 observed in the course of periodontal disease and their subsequent reduction after treatment 6 suggest the involvement of arginase in the inflammatory process. Castro Arginase is an enzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea, and it can be found in mammalian tissues in two isoforms: type-I arginase (Arg-I), which is present in the cytosol and a critical hepatic metabolism enzyme, and type-II arginase (Arg-II), which is located in the mitochondria of extrahepatic tissues and modulates the L-arginine levels for the synthesis of nitric oxide (NO), polyamines, and proteins 7 .…”

Section: Introductionmentioning

confidence: 99%

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Salivary arginase activity after mechanical-chemical therapy

Castro

Cortelli

Rodrigues

et al. 2018

Rev. odontol. UNESP

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ResumoIntrodução: Componentes salivares podem ser usados como biomarcadores para diagnóstico e monitoramento de doenças orais. Há evidências de que um potencial biomarcador, arginase, está associado com os processos inflamatórios da doença periodontal, e após o tratamento sua atividade enzimática é reduzida em concordância com a melhora nos parâmetros clínicos. Objetivo: O presente estudo objetivou avaliar a atividade da arginase salivar em pacientes com gengivite e periodontite tratados com procedimentos mecânicos em estágio único combinados ao uso coadjuvante de enxaguatórios com óleos essenciais ou clorexidina, respectivamente. Material e método: Vinte e seis pacientes com gengivite e 16 pacientes com periodontite receberam exame periodontal completo antes e 3 meses após a terapia, em que mensurações de profundidade de sondagem, perda de inserção clínica, índice de placa e índice gengival foram realizadas. Nestas mesmas consultas os níveis de proteína total e a atividade de arginase salivar foram estabelecidos via espectrofotometria. Resultado: Todos os parâmetros clínicos melhoraram, em ambos os grupos, do exame inicial para o de 3 meses (p < 0,05). Adicionalmente, após tratamento para gengivite houve redução da atividade de arginase salivar e do nível de proteína total. Conclusão: Semelhante aos resultados clínicos, ambos os protocolos terapêuticos afetaram positivamente a atividade da arginase salivar; entretanto, estudos futuros são necessários para clarificar seu potencial como biomarcador salivar para o monitoramento periodontal. AbstractIntroduction: Salivary components can be used as biomarkers for diagnosing and monitoring oral diseases. There is evidence that one potential biomarker, arginase, is associated with the inflammatory processes of periodontal disease, and its enzymatic activity is reduced according to the improvement in the clinical parameters after treatment. Objective: The present study aimed to evaluate the salivary arginase activity in gingivitis and periodontitis patients treated with full-mouth mechanical procedures combined with the adjunctive use of essential oils or chlorhexidine mouthwash, respectively. Material and method: Twenty-six gingivitis and 16 periodontitis patients received complete periodontal examinations at the baseline and 3 months after therapy, in which the periodontal probing depth, clinical attachment loss, plaque index, and gingival index measurements were taken. At these same appointments, the salivary total protein level and salivary arginase activity were also established via spectrophotometry. Result: There were improvements in all of the clinical parameters (p < 0.05) evaluated from the baseline to 3 months in both groups. In addition, the salivary arginase activity and total protein levels were reduced after the gingivitis treatment. Conclusion: Similar to the clinical results, both therapeutic protocols positively affected the salivary arginase activity; however, further studies are necessary to clarify its potential as a salivary biomarker for periodont...

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Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Salivary arginase activity after mechanical-chemical therapy

Castro

Cortelli

Rodrigues

et al. 2018

Rev. odontol. UNESP

Self Cite

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“…Moreover, the likelihood of P.intermedia being detected in saliva is 13 times higher for smokers than for non-smokers. There have been several studies that have shown that the risk of periodontal disease is 1.63 times higher [19], and the risk of periodontitis is 2.5-6 times higher [20]. The likelihood of periodontitis incidence and deterioration is 5-7 times higher in heavy smokers [21].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for the development of oral bacteria in workers according to oral environment

Hong¹

2016

Journal of the Korea Academia-Industrial cooperation Society

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This research examined the oral environmental factors to identify the risk factors for oral bacteria detection.This study comprised of 60 office workers aged between 20 and 65 years, and was performed from January 15 to February 28, 2015. The study variables measured were the stimulated and unstimulated salivary flow rates, salivary buffering, saliva pH, dry mouth at the dorsum of the tongue and the sublingual region, halitosis, and the degree of tongue-coating as oral environmental factors. To identify the presence of oral bacteria, pathogens were detected by extracting the gDNA of the resting salivary flow rate. The risk of S.mutans detection was 15 times higher with smokers, 1.3∼1.6 times higher when the resting or stimulated salivary flow rate was reduced by 1 mm. The risk of P.intermedia detection was 13 times higher in smokers, 4.3 times higher as the severity of oral dryness was lowered, and 4 times higher for adults with a tongue coating than those without. In addition, the risk of detecting TM7 was 5.5 times higher as sublingual dryness was decreased by 1mm. The oral bacterial count will be reduced considerably by smoking cessation education and habits that facilitate a salivary flow rate. Furthermore, adults with good and well-managed dental hygiene are anticipated to have less oral bacteria and fewer dental diseases.

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“…Samples of saliva 6 and from the dorsum of the tongue 5 were collected from the total population (n=154). Saliva samples were collected in the morning, between 8:00 and 11:00.…”

Section: Methodsmentioning

confidence: 99%

Frequency of periodontal pathogens and Helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study

et al. 2016

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Objectives This cross-sectional study compared the frequency of oral periodontopathogens and H. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery.Material and Methods One hundred and fifty-four men and women aged 18-65 were conveniently distributed into four groups. Two groups were composed of individuals who underwent bariatric surgery with (BP) (n=40) and without (BNP) (n=39) periodontitis and two obese control groups with (CP) (n=35) and without (CNP) (n=40) periodontitis. The oral pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Parvimonas micra, Treponema denticola, Tannerella forsythia, Campylobacter rectus, and Helicobacter pylori were detected by a polymerase chain reaction technique using saliva, tongue and stomach biopsy samples.Results Statistical analysis demonstrated that periodontopathogens were highly frequent in the mouth (up to 91.4%). In the bariatric surgically treated group, orally, P. gingivalis, T. denticola and T. forsythia were more frequent in periodontitis, while C. rectus was more frequent in non-periodontitis subjects. Stomach biopsies also revealed the high frequency of five oral species in both candidates for bariatric surgery (91.6%) and the bariatric (83.3%) groups. H. pylori was frequently detected in the mouth (50.0%) and stomach (83.3%). In the stomach, oral species and H. pylori appeared in lower frequency in the bariatric group.Conclusions Obese individuals showed high frequencies of periodontopathogens and H. pylori in their mouths and stomachs. Bariatric surgery showed an inverse microbial effect on oral and stomach environments by revealing higher oral and lower stomach bacterial frequencies.

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Periodontal Therapy Effects on Nitrite Related to Oral Bacteria: A 6‐Month Randomized Clinical Trial

Abstract: The relationship between nitrite and bacterial levels appears weak. Short-term scaling exhibited a greater influence on nitrite concentrations then long-term CHX use.

Cited by 20 publications

References 47 publications

Salivary arginase activity after mechanical-chemical therapy

Salivary arginase activity after mechanical-chemical therapy

Risk factors for the development of oral bacteria in workers according to oral environment

Frequency of periodontal pathogens and Helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study

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