Periodontal tissue engineering by nano beta‐tricalcium phosphate scaffold and fibroblast growth factor‐2 in one‐wall infrabony defects of dogs

Ogawa, Kosuke; Miyaji, Hirofumi; Kato, Akihito; Kosen, Yuta; Momose, Takehito; Yoshida, Takashi; Nishida, Erika; Miyata, Sumiko; Murakami, Shusuke; Takita, Hiroko; Fugetsu, Bunshi; Sugaya, Tsutomu; Kawanami, Masamitsu

doi:10.1111/jre.12352

Cited by 61 publications

(47 citation statements)

References 42 publications

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“…The presentation and release of signaling molecules (such as growth factors) are also important for facilitating stem cell homing, proliferation, and differentiation. In this regard, growth/differentiation factor‐5 (e.g., see ), fibroblast growth factor‐2 (FGF‐2; e.g., see ), platelet‐derived growth factor‐BB (e.g., see ), and many other factors have already been used alone or in combination with various biomaterials for local cell manipulation and periodontal regeneration. Throughout the native regenerative response, different growth factors play multiple roles in specific release sequences and dosages; thus, the sequential release of multiple growth factors to mimic the normal biology of periodontal regeneration can lead to an enhanced outcome (e.g., see ).…”

Section: Harnessing Endogenous Stem Cells Via In Vivo Cell‐materials Imentioning

confidence: 99%

Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations

Wang

et al. 2018

Stem Cells Translational Medicine

159

122

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Periodontitis is a widespread disease characterized by inflammation‐induced progressive damage to the tooth‐supporting structures until tooth loss occurs. The regeneration of lost/damaged support tissue in the periodontium, including the alveolar bone, periodontal ligament, and cementum, is an ambitious purpose of periodontal regenerative therapy and might effectively reduce periodontitis‐caused tooth loss. The use of stem cells for periodontal regeneration is a hot field in translational research and an emerging potential treatment for periodontitis. This concise review summarizes the regenerative approaches using either culture‐expanded or host‐mobilized stem cells that are currently being investigated in the laboratory and with preclinical models for periodontal tissue regeneration and highlights the most recent evidence supporting their translational potential toward a widespread use in the clinic for combating highly prevalent periodontal disease. We conclude that in addition to in vitro cell‐biomaterial design and transplantation, the engineering of biomaterial devices to encourage the innate regenerative capabilities of the periodontium warrants further investigation. In comparison to cell‐based therapies, the use of biomaterials is comparatively simple and sufficiently reliable to support high levels of endogenous tissue regeneration. Thus, endogenous regenerative technology is a more economical and effective as well as safer method for the treatment of clinical patients. Stem Cells Translational Medicine 2019;8:392–403

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Section: Harnessing Endogenous Stem Cells Via In Vivo Cell‐materials Imentioning

confidence: 99%

Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations

Wang

et al. 2018

Stem Cells Translational Medicine

159

122

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“…47 Ogawa et al in 2016 48 stated that, nano-modification of biomaterials might increase the surface area and adsorption of signaling molecules. The observation from the above mentioned study confirms the bioactivity of the electrospinned PCL membranes reinforced with BG/Nhap and its usefulness in periodontal tissue engineering as a GTR/GBR membrane for proliferation and differentiation in to specific cell lineage.…”

Section: Discussionmentioning

confidence: 99%

Electrospinned bioactive glass/nano hydroxyapatite reinforced polycaprolactone GTR/GBR membranes in periodontics- A review

2020

IJPI

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Periodontitis, a chronic inflammatory infectious disease triggered by an interaction between microbial biofilm and host response leading to gingival bleeding, connective tissue destruction , alveolar bone loss and finally causing tooth loss. Periodontal regeneration or restoration is the ultimate goal of any periodontal treatment. This can be achieved by GTR/GBR [Guided Tissue Regeneration/Guided Bone Regeneration] membranes along with bone replacement grafts. With the evolution of Tissue engineering and different generation of GTR/GBR nanofibrous membranes, periodontal restoration or regeneration can be easily and rapidly achieved . Nanofibrous GTR/GBR Membranes can be fabricated using natural or synthetic polymers by different techniques such as Phase separation, Self assembly and Electrospinning [E-spinning]. Of these, E-spinning is the most widely studied technique and also seems to exhibit the most promising results for Tissue Engineering [TE] applications . This review addresses the Electrospinning method of GTR/GBR membrane fabrication using Bioactive Glass [BG]/Nano Hydroxyapatite[nHAP] reinforced polycaprolactone polymer and its advantages and disadvantages.

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“…Nanomodification of biomaterials via nanosized bioceramics might play a major role in promoting their properties for biomedical applications [23][24][25][26] . Ibara et al and Ogawa et al prepared a 3D collagen scaffold with surfacemodifications using beta-tricalcium phosphate (β-TCP) nanoparticles and subsequently implanted the scaffold in combination with fibroblast growth factor-2 (FGF-2) into rat connective tissue 27,28) . They observed that the promotion of cell and tissue ingrowth into the scaffold was facilitated by β-TCP nanoparticle modification.…”

Section: Introductionmentioning

confidence: 99%

Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds

et al. 2017

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Three-dimensional collagen scaffolds coated with beta-tricalcium phosphate (β-TCP) nanoparticles reportedly exhibit good bioactivity and biodegradability. Dose effects of β-TCP nanoparticles on biocompatibility and bone forming ability were then examined. Collagen scaffold was applied with 1, 5, 10, and 25 wt% β-TCP nanoparticle dispersion and designated TCP1, TCP5, TCP10, and TCP25, respectively. Compressive strength, calcium ion release and enzyme resistance of scaffolds with β-TCP nanoparticles applied increased with β-TCP dose. TCP5 showed excellent cell-ingrowth behavior in rat subcutaneous tissue. When TCP10 was applied, osteoblastic cell proliferation and rat cranial bone augmentation were greater than for any other scaffold. The bone area of TCP10 was 7.7-fold greater than that of non-treated scaffold. In contrast, TCP25 consistently exhibited adverse biological effects. These results suggest that the application dose of β-TCP nanoparticles affects the scaffold bioproperties; consequently, the bone conductive ability of TCP10 was remarkable.

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Periodontal tissue engineering by nano beta‐tricalcium phosphate scaffold and fibroblast growth factor‐2 in one‐wall infrabony defects of dogs

Abstract: Japan Running titlePeriodontal healing by nano β-TCP and FGF-2 Key wordsPeriodontal tissue engineering, Fibroblast growth factor-2 (FGF-2), β-tricalcium phosphate

Cited by 61 publications

References 42 publications

Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations

Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations

Electrospinned bioactive glass/nano hydroxyapatite reinforced polycaprolactone GTR/GBR membranes in periodontics- A review

Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds

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