Periodontitis: a potential risk factor for Alzheimer's disease

Cerajewska, Tanya L.; Davies, Malcolm; West, Nicola

doi:10.1038/bdjteam.2016.62

Cited by 20 publications

(24 citation statements)

References 135 publications

(149 reference statements)

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“…Sir, we were delighted by the paper by Cerajewska et al, 1 which matches exactly our point of view presented briefly previously in this Journal 2 describing the potential role of periopathogens in the development of cognitive impairment among elderly people.…”

Section: Periodontology a Vaccine For Periodontopathogenssupporting

confidence: 65%

“…In the early 2000s orthodontic undergraduate education was vibrant and engaged students in learning the necessary clinical skills. 1 In addition, many consultants in the hospital orthodontic services ran 'extended attachments' which gave the opportunity for GDPs to learn orthodontics in a supportive educational environment. In the past ten years the amount of undergraduate orthodontic teaching has been reduced by the GDC undergraduate educational 'outcomes' in combination with pressures on dental schools.…”

Section: Filling the Vacuummentioning

confidence: 99%

“…Hence, an association between periodontitis and Alzheimer disease cannot be reasonably concluded from such studies as stated in the article provided by Cerajewska. 1 Undoubtedly, a local chronic inflammation may trigger a systemic inflammatory host response within different parts of the human body (brain, heart, vessels, joints).…”

Section: Periodontology a Vaccine For Periodontopathogensmentioning

confidence: 99%

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Hobson

2015

Br Dent J

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Section: Periodontology a Vaccine For Periodontopathogenssupporting

confidence: 65%

Section: Filling the Vacuummentioning

confidence: 99%

Section: Periodontology a Vaccine For Periodontopathogensmentioning

confidence: 99%

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Hobson

2015

Br Dent J

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“… Genetic factors like Interleukin-1 gene polymorphism, Tumor necrosis factor-α gene polymorphism and environmental factors like smoking also play a role in relation between Alzheimer's disease and periodontitis. 39 Overall, this literature review suggests that periodontitis causing systemic inflammation has a significant relationship with the Alzheimer's disease. Though anti-inflammatory drugs cannot prevent the Alzheimer's disease, they can always slow down its progression by its influence on the pro-inflammatory molecules which is the main reason for link between Alzheimer's disease and periodontitis.…”

Section: Based On Genetic and Environmental Factorsmentioning

confidence: 87%

RELATIONSHIP BETWEEN ALZHEIMER’S DISEASE & PERIODONTITIS - A LITERATURE REVIEW

Nivetha¹,

Vummidi²,

Ilango³

et al. 2020

IJMBS

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Periodontitis is the microbial infection often causing inflammation of the gingiva, bone loss and tooth mobility. Apart from periodontitis, periodontal bacteria like Porphyromonas gingivalis, Spirochetes, Treponema denticola are known to cause systemic diseases such as cardiovascular diseases, preterm low birth weight infants, Alzheimer's diseases etc. Alzheimer's disease is a progressive mental deterioration of the brain that can occur in middle or old aged individual due to generalized regeneration of neurons in the brain. Literature has shown that inflammation plays a vital role in the progression of Alzheimer's disease where periodontitis is a risk factor proving the focal infection theory. This article reviews the relationship of periodontitis in Alzheimer's disease and its role in modifying the disease.

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“…There is new scientific evidence published recently that aside the gut microbiome, oral microflora is also able to influence brain functions (Orr et al, 2020). Numerous studies have shown that periodontal disease is associated with neurodegeneration and cognitive decline (Kamer et al, 2008;Cerajewska et al, 2016;Wang et al, 2019). Chang and coauthors reported that chronic periodontitis of 10 years duration was associated with a 1.707-fold increase in the risk of developing AD (Chen et al, 2017).…”

Section: Oral Microbiome and Alzheimer's Diseasementioning

confidence: 99%

The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

Askarova

Umbayev

Masoud

et al. 2020

Front. Cell. Infect. Microbiol.

154

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Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have a tremendous impact on the human physiology in healthy individuals and during an illness. Intestinal microbiome can influence one's health either directly by secreting biologically active substances such as vitamins, essential amino acids, lipids et cetera or indirectly by modulating metabolic processes and the immune system. In recent years considerable information has been accumulated on the relationship between gut microbiome and brain functions. Moreover, significant quantitative and qualitative changes of gut microbiome have been reported in patients with Alzheimer's disease. On the other hand, gut microbiome is highly sensitive to negative external lifestyle aspects, such as diet, sleep deprivation, circadian rhythm disturbance, chronic noise, and sedentary behavior, which are also considered as important risk factors for the development of sporadic Alzheimer's disease. In this regard, this review is focused on analyzing the links between gut microbiome, modern lifestyle, aging, and Alzheimer's disease.

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Periodontitis: a potential risk factor for Alzheimer's disease

Cited by 20 publications

References 135 publications

Filling the vacuum

Filling the vacuum

RELATIONSHIP BETWEEN ALZHEIMER’S DISEASE & PERIODONTITIS - A LITERATURE REVIEW

The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

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