Periodontitis and edentulism as risk indicators for mortality: Results from a prospective cohort study with 20 years of follow‐up

Abstract

Periodontitis is a chronic infectious-inflammatory disease associated with dysbiotic dental plaque biofilms characterized by the destruction of the tooth-supporting tissues (periodontal ligament and alveolar bone). 1 This disease has a high global prevalence in different populations, [2][3][4][5][6] and there is mounting evidence that is independently associated with different systemic diseases and co-morbidities, either directly by bacterial invasion or indirectly through systemic inflammation. [7][8][9][10][11][12] These include hypertension, 13 coronary heart disease (CHD) 14 obesity, 15 adverse pregnancy outcomes, 16 diabetes mellitus, 17,18 and autoimmune diseases such as rheumatoid arthritis 19 and cancer. 20,21 Periodontitis has also shown a significant impact in general health care as demonstrated from insurance data 22 and in patients attending for dental care. 23 There is also epidemiologic evidence demonstrating that subjects with periodontitis have

Modulation of allograft immune responses by Porphyromonas gingivalis lipopolysaccharide administration in a rat model of kidney transplantation

“…This study suggests that periodontitis suppresses allograft rejection after KT, but it does not necessarily imply that periodontitis is bene cial for KT recipients, which we previously referred to as the "paradox of transplantation" [10]. Periodontitis patients have a higher risk for cardiovascular disease and increased mortality [36] [37]. Indeed, KT recipients with severe chronic periodontitis also have a lower survival rate after transplantation compared with those without severe chronic periodontitis [9][38].…”

Healthy lifestyles are associated with a better response to periodontal therapy: A prospective cohort study

“…Hence, a direct biological effect of lifestyle behaviours on the periodontium is suggested. These findings may be relevant for clinicians because those behaviours may represent potential targets of interventions in the context of the Step 1 of periodontal therapy (Sanz et al, 2020), and for researchers because they may represent potential confounders to be considered when analysing the risk factors of periodontitis or its association with systemic diseases (Antonoglou et al, 2023; Baima et al, 2022; Botelho et al, 2022; D'Aiuto et al, 2018; Marruganti, Baima, Aimetti, et al, 2023; Marruganti, Shin, Jim, et al, 2023; Romandini et al, 2020, 2021).…”

Effect of Periodontitis and Periodontal Therapy on Oral and Gut Microbiota

“…It is characterized by a nonresolving inflammation resulting from a polymicrobial dysbiosis of the oral subgingival biofilm that may eventually lead to tooth loss if left untreated. Moreover, periodontitis has been linked to a broad spectrum of NCDs through blood translocation of oral bacteria via blood, bacterial aspiration into the lower respiratory tract, and elevation of LGSI biomarkers (Hajishengallis and Chavakis 2021; Antonoglou et al 2023; Marruganti et al 2023). Periodontal treatment is effective in clinically controlling the disease, reducing LGSI markers, and restoring a healthy oral microbial ecosystem by decreasing the relative abundance of specific taxa and related by-products (D’Aiuto et al 2018; Romano et al 2019; Johnston et al 2021).…”