Periodontitis as a potential risk factor for chronic obstructive pulmonary disease: A retrospective study

Deo, Vikas; Bhongade, Manohar L; Ansari, Salman; Chavan, Ramesh Sundersing

doi:10.4103/0970-9290.59456

Cited by 57 publications

(65 citation statements)

References 2 publications

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“…Merely on the basis of a few spirometry parameters, some cross-sectional and case-control studies reported significant associations of periodontal disease with history of COPD and lung function decline [4][5][6][7][8]12]. Furthermore, periodontal disease has been related to the longitudinal decline in spirometric lung volumes [9,10,14].…”

Section: Introductionmentioning

confidence: 99%

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Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study

et al. 2012

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This study aimed to assess the potential association of periodontal diseases with lung volumes and airflow limitation in a general adult population.Based on a representative population sample of the Study of Health in Pomerania (SHIP), 1463 subjects aged 25-86 years were included. Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth. Lung function was measured using spirometry, body plethysmography and diffusing capacity of the lung for carbon monoxide. Linear regression models using fractional polynomials were used to assess associations between periodontal disease and lung function. Fibrinogen and high-sensitivity C-reactive protein (hs-CRP) were evaluated as potential intermediate factors.After full adjustment for potential confounders mean CAL was significantly associated with variables of mobile dynamic and static lung volumes, airflow limitation and hyperinflation (p,0.05). Including fibrinogen and hs-CRP did not change coefficients of mean CAL; associations remained statistically significant. Mean CAL was not associated with total lung capacity and diffusing capacity of the lung for carbon monoxide. Associations were confirmed for mean probing depth, extent measures of CAL/probing depth and number of missing teeth.Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in this general adult population sample. Systemic inflammation did not provide a mechanism linking both diseases. @ERSpublications Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in an adult population

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Section: Introductionmentioning

confidence: 99%

“…To date, few studies have investigated the relationship between periodontitis [4][5][6][7][8][9][10][11][12][13][14] or oral hygiene [12,13,15] and respiratory diseases, although common causes might exist. Both diseases have been related to systemic inflammation [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study

et al. 2012

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“…Kowalski et al examined the periodontal status of 100 patients with COPD, and observed a high prevalence (84.2%) of periodontitis and a positive correlation of PD and PI with the severity of COPD (15). In addition, a high prevalence of CP and obvious resorption of alveolar bone were found in patients with severe COPD (15)(16)(17). Zeng performed a meta-analysis to ascertain the relationship between PD and COPD, and found that PD was a significant and independent risk factor of COPD (18).…”

Section: Discussionmentioning

confidence: 99%

Toll-like receptor 4 polymorphism is associated with increased susceptibility to chronic obstructive pulmonary disease in Han Chinese patients with chronic periodontitis

Wang

et al. 2016

J Oral Sci

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“…It was observed that a loss of 20% of the alveolar bone leads to an increased risk for development of COPD by 60%. However, it should be noted that the reduction of FEV1 is related not only to the existence of COPD but also to other respiratory diseases [19].…”

Section: Epidemiology Of Copd and Periodontitismentioning

confidence: 99%

Periodontitis and chronic obstructive pulmonary disease

2012

Dental Abstracts

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Chronic periodontitis and chronic obstructive pulmonary disease (COPD) are chronic inlammatory diseases in which neutrophilic inlammation plays a major role. There are a few studies showing that these two entities share various predisposing factors and pathogenetic mechanisms; however, a direct connection between them has not yet been achieved. Epidemiology data may also show a connection between the two conditions. Neutrophilic inlammation in periodontitis and COPD is orchestrated by CD8+ lymphocytes and macrophages, leading to the aggregation of neutrophils and causing an imbalance to the proteases and antiproteases equilibrium. Finally, further research is needed to clarify the common pathogenesis of the two diseases to optimize their therapeutic management.

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Periodontitis as a potential risk factor for chronic obstructive pulmonary disease: A retrospective study

Cited by 57 publications

References 2 publications

Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study

Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study

Toll-like receptor 4 polymorphism is associated with increased susceptibility to chronic obstructive pulmonary disease in Han Chinese patients with chronic periodontitis

Periodontitis and chronic obstructive pulmonary disease

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