Periodontitis as a risk factor for systemic disease: Are microparticles the missing link?

Badran, Zahi; Struillou, Xavier; Verner, Christian; Clee, T; Rakić, Mia; Martínez, María Carmen; Soueidan, Assem

doi:10.1016/j.mehy.2015.02.013

Cited by 33 publications

(33 citation statements)

References 14 publications

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“…Periodontitis is an oral inflammatory disease associated with many systemic conditions, including cardiovascular disease, diabetes, rheumatoid arthritis, preeclampsia and preterm birth (1). Periodontitis is clinically significant because it leads to progressive alveolar bone destruction and connective tissue attachment loss.…”

Section: Introductionmentioning

confidence: 99%

Effect of sclerostin removal <i>in vivo</i> on experimental periodontitis in mice

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Effect of sclerostin removal <i>in vivo</i> on experimental periodontitis in mice

et al. 2016

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“…Chronic periodontitis could represent a persistent reservoir of microparticles released by multiple cells in an inflammatory context, and hence might be associated with increased prevalence of systemic diseases (Badran et al, 2015). The link between periodontitis and diabetes mellitus is well known (Grossi and Genco, 1998).…”

Section: Discussionmentioning

confidence: 99%

Assessment of CASP gene polymorphisms in periodontal disease

Sw¹,

Kim²,

Chung³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Caspases (CASP) are intracellular proteases that play roles as mediators of apoptosis. Activation of caspase 3 is enhanced in chronic periodontitis. Thus, we hypothesized that single nucleotide polymorphisms (SNPs) of CASP genes might be associated with this condition in the Korean population. To investigate whether such polymorphisms might be involved in the development of periodontal disease, 51 patients and 33 control subjects were assessed. A total of 201 CASP gene SNPs were analyzed with genotypes being determined using and Axiom™ genomewide human assay. SNPStats and SPSS 18.0 were used for the analysis of genetic data and logistic regression models were utilized to evaluate odds ratios, 95% confidence intervals, and P values. Of the 201 SNPs, only three (rs12108497, rs4647602, and rs113420705, all in the CASP3 gene) were significantly associated with chronic periodontitis (P < 0.05). The minor allele frequencies of these SNPs were higher in the patient group than in the control group. In addition, the TC and GT haplotypes 18070 S.W. Kang et al. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18069-18077 (2015) formed by rs4647602 and rs113420705 were found to be associated with chronic this disease (TC haplotype, P = 0.0039; GT haplotype, P = 0.002). These results suggest that CASP3 gene polymorphisms may be associated with susceptibility to periodontal disease in the Korean population.

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“…Recent data agreed that chronic periodontitis is a risk factor for many multisystem diseases including rheumatoid arthritis and other auto-inflammatory rheumatic conditions, cardio and cerebrovascular disease (atherosclerosis, myocardial infarction, stroke), diabetes, osteoporosis, respiratory and neurodegenerative disorders, adverse pregnancy outcomes [1,17,18]. In fact, locally exacerbated and ongoing systemic inflammation, specific tissue damage, mutual triggers (smoking, iatrogenic factors) acting in a genetic vulnerable individuals (HLA-DRβ1) uphold a modulating bidirectional relationship between periodontitis and the above mentioned entities [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: A Closer Look To Periodontitis 21 Pathobiology Of Periodonmentioning

confidence: 99%

Rheumatoid Arthritis and Periodontal Disease: A Complex Interplay

Ancuţa¹,

Iordache²,

Ancuta³

et al. 2017

New Developments in the Pathogenesis of Rheumatoid Arthritis

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Recent advances in understanding the dynamic pathways involved in the pathogenesis of rheumatoid arthritis have emphasized the pivotal role of pro-inflammatory cytokines, inflammatory cells, endothelial cell activation and matrix degradation, acting in a genetically predisposed environment. On the other hand, there are significant amounts of data highlighting the potential role of bacteria (leading periodonthopatic pathogen Porfiromonas gingivalis) in promoting different types of arthritis, as well as the influence of periodontis (an infectious-inflammatory condition) as etiological or modulating factor in different pathologies, including cardio-vascular disorders, diabetes, respiratory disease and inflammatory rheumatic disorders (such as rheumatoid arthritis, ankylosing spondylitis and lupus). The present chapter deals with the possible association between rheumatoid arthritis and periodontitis as entities with common pathological events.

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Periodontitis as a risk factor for systemic disease: Are microparticles the missing link?

Cited by 33 publications

References 14 publications

Effect of sclerostin removal <i>in vivo</i> on experimental periodontitis in mice

Effect of sclerostin removal <i>in vivo</i> on experimental periodontitis in mice

Assessment of CASP gene polymorphisms in periodontal disease

Rheumatoid Arthritis and Periodontal Disease: A Complex Interplay

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