Periodontitis, cardiovascular disease and pregnancy outcome – focal infection revisited?

Ide, Mark; Linden, Gerard J.

doi:10.1038/sj.bdj.2014.903

Cited by 12 publications

(9 citation statements)

References 117 publications

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“…The disease appears as a breakdown of the periodontal ligament and alveolar bone that can lead to loss of teeth (2, 3). Periodontitis affects the majority of adults worldwide (4) and may contribute to various systemic diseases, including atherosclerosis, cardiovascular disease (4, 5), diabetes (6), and rheumatoid arthritis (7), among others (8). Despite decades of research, the substantial differences among periodontitis patients in disease incidence, progressivity, and response to treatment are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment

et al. 2017

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Periodontal disease affects the majority of adults worldwide and has been linked to numerous systemic diseases. Despite decades of research, the reasons for the substantial differences among periodontitis patients in disease incidence, progressivity, and response to treatment remain poorly understood. While deep sequencing of oral bacterial communities has greatly expanded our comprehension of the microbial diversity of periodontal disease and identified associations with healthy and disease states, predicting treatment outcomes remains elusive. Our results suggest that combining multiple omics approaches enhances the ability to differentiate among disease states and determine differential effects of treatment, particularly with the addition of metabolomic information. Furthermore, multi-omics analysis of biofilm community instability indicated that these approaches provide new tools for investigating the ecological dynamics underlying the progressive periodontal disease process.

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Section: Introductionmentioning

confidence: 99%

Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment

et al. 2017

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“…While mild to moderate forms of the disease affect approximately half of the US adults, up to 15% of the population suffer from severe forms of the disease [ 1 , 2 ] that will result in a decreased quality of life [ 3 ] and high dental care costs [ 4 ]. Over the last decade, epidemiologic evidence has accumulated to suggest that periodontal disease represents a risk factor for more serious systemic diseases such as cardiovascular disease, type 2 diabetes and preterm low birth weight [ 5 , 6 ]. Therefore, it is considered a major public health problem for both developed and developing countries.…”

Section: Introductionmentioning

confidence: 99%

Dual Action of Myricetin on Porphyromonas gingivalis and the Inflammatory Response of Host Cells: A Promising Therapeutic Molecule for Periodontal Diseases

et al. 2015

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Periodontitis that affects the underlying structures of the periodontium, including the alveolar bone, is a multifactorial disease, whose etiology involves interactions between specific bacterial species of the subgingival biofilm and the host immune components. In the present study, we investigated the effects of myricetin, a flavonol largely distributed in fruits and vegetables, on growth and virulence properties of Porphyromonas gingivalis as well as on the P. gingivalis-induced inflammatory response in host cells. Minimal inhibitory concentration values of myricetin against P. gingivalis were in the range of 62.5 to 125 μg/ml. The iron-chelating activity of myricetin may contribute to the antibacterial activity of this flavonol. Myricetin was found to attenuate the virulence of P. gingivalis by reducing the expression of genes coding for important virulence factors, including proteinases (rgpA, rgpB, and kgp) and adhesins (fimA, hagA, and hagB). Myricetin dose-dependently prevented NF-κB activation in a monocyte model. Moreover, it inhibited the secretion of IL-6, IL-8 and MMP-3 by P. gingivalis-stimulated gingival fibroblasts. In conclusion, our study brought clear evidence that the flavonol myricetin exhibits a dual action on the periodontopathogenic bacterium P. gingivalis and the inflammatory response of host cells. Therefore, myricetin holds promise as a therapeutic agent for the treatment/prevention of periodontitis.

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“…Even today, advances in technology, tooth extraction is still one of the most common dental procedures and such beliefs remain . There are still debates on the focal infection theory , and a new problem is emerging. With the introduction of dental implants, extraction and replacement of teeth with titanium counterparts has become common practice.…”

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confidence: 99%

Activation and resolution of periodontal inflammation and its systemic impact

Hastürk¹,

Kantarcı²

2015

Periodontology 2000

185

172

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Inflammation is a highly organized event impacting upon organs, tissues and biological systems. Periodontal diseases are characterized by dysregulation or dysfunction of resolution pathways of inflammation resulting in a failure of healing and a dominant chronic, progressive, destructive and predominantly unresolved inflammation. The biological consequences of inflammatory processes may be independent of the etiological agents such as trauma, microbial organisms and stress. The impact of the inflammatory pathological process depends upon the affected tissues or organ system. Whilst mediators are similar, there is a tissue specificity for the inflammatory events. It is plausible that inflammatory processes in one organ could directly lead to pathologies in another organ or tissue. Communication between distant parts of the body and their inflammatory status is also mediated by common signaling mechanisms mediated via cells and soluble mediators. This review focuses on periodontal inflammation, its systemic associations and advances in therapeutic approaches based on mediators acting through orchestration of natural pathway to resolution of inflammation. We also discuss a new treatment concept where natural pathways of resolution of periodontal inflammation can be used to limit systemic inflammation and promote healing and regeneration.

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Periodontitis, cardiovascular disease and pregnancy outcome – focal infection revisited?

Cited by 12 publications

References 117 publications

Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment

Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment

Dual Action of Myricetin on Porphyromonas gingivalis and the Inflammatory Response of Host Cells: A Promising Therapeutic Molecule for Periodontal Diseases

Activation and resolution of periodontal inflammation and its systemic impact

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