Periodontitis changes renal structures by oxidative stress and lipid peroxidation

“…Severe periodontitis (SP) affects approximately 11% of the adults worldwide (Richards, ). Besides, numerous evidences indicated that periodontitis is correlated with multiple systemic diseases including diabetes (Curtis, ), preterm low birthweight (Vettore et al, ), and kidney diseases (Franca et al, ). According to previous study, supplying of bacterial pathogens (Pussinen, Paju, Mantyla, & Sorsa, ) and the releasing of inflammatory cytokines (Artese et al, ) are possible sources for periodontitis occurrence.…”

Section: Introductionmentioning

confidence: 99%

“…, and kidney diseases (Franca et al, 2017). According to previous study, supplying of bacterial pathogens (Pussinen, Paju, Mantyla, & Sorsa, 2007) and the releasing of inflammatory cytokines (Artese et al, 2015) are possible sources for periodontitis occurrence.…”

mentioning

confidence: 97%

Expression of Concern: MiRNA‐218 regulates osteoclast differentiation and inflammation response in periodontitis rats through Mmp9

Guo

Zeng

Miao

et al. 2019

Cellular Microbiology

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Periodontitis is a multiple infection and inflammatory disease featured by connective tissue homeostasis loss, periodontal inflammation, and alveolar bone resorption. MicroRNAs (miRNAs) are involved in the mediation of a large scale of pathological processes. Here, we show that miRNA‐218 provides protective effect on periodontitis via regulation of matrix metalloproteinase‐9 (Mmp9). This pathway is aberrant in periodontium from rats with periodontitis and human periodontal ligament progenitor cells stimulated by lipopolysaccharide, with downregulation of miR‐218 and higher levels of Mmp9 compared with periodontium from healthy rats and cells without stimulation. Overexpression of miR‐218 can suppress the degradation of Collagen Types I and IV and dentin sialoprotein (DSP), attenuate osteoclast formation, and inhibit the secretion of proinflammatory cytokines. On the other hand, overexpression of Mmp9 promotes the degradation of Collagen Types I and IV and DSP as well as RANKL‐induced osteoclast formation and elevates inflammatory factors levels. Furthermore, the inhibitory effect of miR‐218 was prevented by rescuing the Mmp9 expression. In addition, we also have showed that miR‐218 was able to attenuate bone resorption and inflammation in a periodontitis rat model. Collectively, our findings therefore suggest that miR‐218 acts as a protective role in periodontitis through the regulation of Mmp9.

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“…A similar model has been used previously in several other studies (Dos Santos Carvalho et al, 2017;França et al, 2017;Vasconcelos et al, 2019). The animals were divided into three groups: control group (n = 8), which received no treatment or induction of periodontal disease; periodontitis (n = 8), and bromelain (n = 8), which received intraperitoneal treatment with bromelain (bromelain from pineapple stem, Sigma-Aldrich®, São Paulo, SP, Brazil) 15 mg/kg for 20 days + induction of periodontitis.…”

Section: Experimental Designmentioning

confidence: 99%

Bromelain reduces the non‐alcoholic fatty liver disease and periodontal damages caused by ligature‐induced periodontitis

Alves¹,

Carvalho²,

Silva

et al. 2020

Oral Diseases

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Objective: The objective of this research was to evaluate the effects of bromelain (derived from Ananas comosus) upon periodontitis in rats. Materials and Methods: Twenty-four rats were separated into groups: control, periodontitis, and bromelain treatment. Bromelain was administered daily by intraperitoneal injection for 20 days. Periodontitis was induced by ligature around the first molars. Oral parameters and blood biomarkers were measured. The histopathological evaluation of the hepatic tissue was performed. Bromelain treatment significantly reduced several oral inflammatory parameters, alveolar bone loss, and blood biomarkers compared to the rats on periodontitis. Results: Treatment with bromelain improved the steatosis score. Bromelain used in ligature-induced periodontitis in rats was able to reduce the oral inflammatory parameters Gingival Bleeding Index (GBI), tooth mobility (TM), probing pocket depth (PPD), malondialdehyde (MDA), alveolar bone height (ABH) and gingival myeloperoxidase (MPO) and blood parameters (cholesterol, triglycerides, alanine aminotransferase, and aspartate aminotransferase). Bromelain treatment reduced the impact of periodontitis, such as the reduction of hepatic steatosis and improvement in the dosages of MDA and GSH. Conclusion: Bromelain acts as a potential adjunct in the non-surgical treatment of periodontitis and, consequently, reduces the impact of periodontitis, acting as antiinflammatory and antioxidant. K E Y W O R D S alveolar bone loss, anti-inflammatory, antioxidant, periodontal diseases, proteinase How to cite this article: Alves EHP, Carvalho ADS, Silva FRP, et al. Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.

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Periodontitis changes renal structures by oxidative stress and lipid peroxidation

Cited by 69 publications

References 45 publications

Periodontitis causes abnormalities in the liver of rats

Periodontitis causes abnormalities in the liver of rats

Expression of Concern: MiRNA‐218 regulates osteoclast differentiation and inflammation response in periodontitis rats through Mmp9

Bromelain reduces the non‐alcoholic fatty liver disease and periodontal damages caused by ligature‐induced periodontitis

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