Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress

Li, Ling; Zhang, Yali; Liu, Xingyu; Meng, Xiang; Zhao, Rong-Quan; Ou, Lin-Lin; Li, Baozhu; T, Xing

doi:10.3389/fmicb.2021.656372

Cited by 49 publications

(55 citation statements)

References 162 publications

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“…Therefore, oral bacteria may disseminate in the whole body, which will extend the location of microbial dysbiosis disorders. Importantly, this chronic inflammatory context is associated with an elevated risk of systemic conditions, which reinforces the need to better understand and treat periodontitis-like diseases ( 114 ).…”

Section: Examples Of Hmgb1 and Complement Dysfunctions And Crosstalk ...mentioning

confidence: 99%

Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse

et al. 2022

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Our immune system responds to infectious (PAMPs) and tissue damage (DAMPs) signals. The complement system and alarmin High-Mobility Group Box 1 (HMGB1) are two powerful soluble actors of human host defense and immune surveillance. These systems involve molecular cascades and amplification loops for their signaling or activation. Initially activated as alarm raising systems, their function can be finally switched towards inflammation resolution, where they sustain immune maturation and orchestrate repair mechanisms, opening the way back to homeostasis. However, when getting out of control, these defense systems can become deleterious and trigger serious cellular and tissue damage. Therefore, they can be considered as double-edged swords. The close interaction between the complement and HMGB1 pathways is described here, as well as their traditional and non-canonical roles, their functioning at different locations and their independent and collective impact in different systems both in health and disease. Starting from these systems and interplay at the molecular level (when elucidated), we then provide disease examples to better illustrate the signs and consequences of their roles and interaction, highlighting their importance and possible vicious circles in alarm raising and inflammation, both individually or in combination. Although this integrated view may open new therapeutic strategies, future challenges have to be faced because of the remaining unknowns regarding the molecular mechanisms underlying the fragile molecular balance which can drift towards disease or return to homeostasis, as briefly discussed at the end.

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Section: Examples Of Hmgb1 and Complement Dysfunctions And Crosstalk ...mentioning

confidence: 99%

Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse

et al. 2022

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“…Furthermore, FimA activates CXC-chemokine receptor 4 (CXCR4) and TLR2 to induce cyclic adenosine monophosphate-dependent protein kinase A signaling, which not only results in disruption of phagocytosis by macrophages ( 113 ), but also inhibits host immune clearance of P. gingivalis ( 114 ). Dysfunctions of both macrophages and CXCR4 have been reported to be associated with NAFLD ( 115 , 116 ).…”

Section: P Gingivalis and Nafldmentioning

confidence: 99%

Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis

et al. 2022

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Gut microbiota play many important roles, such as the regulation of immunity and barrier function in the intestine, and are crucial for maintaining homeostasis in living organisms. The disruption in microbiota is called dysbiosis, which has been associated with various chronic inflammatory conditions, food allergies, colorectal cancer, etc. The gut microbiota is also affected by several other factors such as diet, antibiotics and other medications, or bacterial and viral infections. Moreover, there are some reports on the oral-gut-liver axis indicating that the disruption of oral microbiota affects the intestinal biota. Non-alcoholic fatty liver disease (NAFLD) is one of the systemic diseases caused due to the dysregulation of the oral-gut-liver axis. NAFLD is the most common liver disease reported in the developed countries. It includes liver damage ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. Recently, accumulating evidence supports an association between NAFLD and dysbiosis of oral and gut microbiota. Periodontopathic bacteria, especially Porphyromonas gingivalis, have been correlated with the pathogenesis and development of NAFLD based on the clinical and basic research, and immunology. P. gingivalis was detected in the liver, and lipopolysaccharide from this bacteria has been shown to be involved in the progression of NAFLD, thereby indicating a direct role of P. gingivalis in NAFLD. Moreover, P. gingivalis induces dysbiosis of gut microbiota, which promotes the progression of NAFLD, through disrupting both metabolic and immunologic pathways. Here, we review the roles of microbial dysbiosis in NAFLD. Focusing on P. gingivalis, we evaluate and summarize the most recent advances in our understanding of the relationship between oral-gut microbiome symbiosis and the pathogenesis and progression of non-alcoholic fatty liver disease, as well as discuss novel strategies targeting both P. gingivalis and microbial dysbiosis.

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“…The association between oral health and the general body system has been established by research studies [1,2]. There are oral manifestations of systemic diseases and drugs on one hand, and oral systemic interactions where periodontitis has been associated with non-communicable diseases (NCDs) like diabetes mellitus, coronary heart disease, infertility in males, rheumatoid arthritis, chronic kidney disease among others on the other hand [3][4][5][6][7][8][9][10][11][12]. Thus, there is the need for collaboration between medical and dental practitioners in managing patients with NCDs.…”

Section: Introductionmentioning

confidence: 99%

Dental knowledge and reasons for non-utilization of dental services among final year undergraduates in a University of Port Harcourt, Nigeria

E¹,

Omotunde²

2022

GSC Adv. Res. Rev.

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Background: Oral systemic interactions have been established by scientific studies through the common risk factor and inflammatory pathways. Since the health practitioners are the ones that those with oral diseases first present to, there is the need for them to be dentally aware so they can help patients get holistic care and thus improve their quality of life. Methodology: One hundred and eighty-five participants in final year in health-related professions (Dentistry, Pharmacy, Medicine and surgery and Nursing) were recruited. Self-administered questionnaires were used to collect data on dental knowledge and service utilization. Data was analyzed using IBM SPSS (Statistical Package for the Social Sciences) version 25. Results: Seventy percent participants in Dentistry and Medicine & Surgery knew a dentist should be visited twice yearly. One third of participants in Pharmacy said the dentist should only be visited when there is a toothache (p=0.002). One third of participants from Medicine & Surgery have not heard of dental caries. Participants from Pharmacy had the least knowledge about dental caries, calculus and scaling and polishing (p=<0.001). Half of participants from Medicine & Surgery and Pharmacy did not know that patients with facial swelling should be sent to the dentists for management (p=0.001). Four-fifth of participants from Pharmacy do not know what halitosis is (p= <0.0001). 61.6% of the study population had never had a dental visit and only 14.5% reported to have had regular dental visits. Conclusion: Dental awareness is slightly improved among the students but there is still the need translate knowledge to practice.

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Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress

Cited by 49 publications

References 162 publications

Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse

Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse

Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis

Dental knowledge and reasons for non-utilization of dental services among final year undergraduates in a University of Port Harcourt, Nigeria

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