2022
DOI: 10.3389/fnins.2022.876582
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Periodontitis Salivary Microbiota Aggravates Ischemic Stroke Through IL-17A

Abstract: Although epidemiological studies suggest that periodontitis is tightly associated with ischemic stroke, its impact on ischemic stroke and the underlysing mechanisms are poorly understood. Recent studies have shown that alteration in gut microbiota composition influences the outcomes of ischemic stroke. In the state of periodontitis, many oral pathogenic bacteria in the saliva are swallowed and transmitted to the gut. However, the role of periodontitis microbiota in the pathogenesis and progression of ischemic … Show more

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Cited by 19 publications
(17 citation statements)
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“…This scenario also raises questions regarding the role of chronic periodontal inflammation as a risk factor in various systemic diseases, e.g., atherosclerosis, cardiovascular disease, ischemic stroke, Alzheimer’s disease, etc. [ 34 , 35 , 36 , 37 , 38 ]. The patient must be informed of the potential systemic risks of inadequate periodontal treatment that allows for continued inflammation.…”
Section: Treatment Recommendation Based On Reevaluation Of Therapymentioning
confidence: 99%
“…This scenario also raises questions regarding the role of chronic periodontal inflammation as a risk factor in various systemic diseases, e.g., atherosclerosis, cardiovascular disease, ischemic stroke, Alzheimer’s disease, etc. [ 34 , 35 , 36 , 37 , 38 ]. The patient must be informed of the potential systemic risks of inadequate periodontal treatment that allows for continued inflammation.…”
Section: Treatment Recommendation Based On Reevaluation Of Therapymentioning
confidence: 99%
“…Stroke-induced stress can cause immunosuppression and thus increase susceptibility to infection ( 45 ). An animal experiment verified that mice receiving intragastric administration of periodontitis salivary microbiota increased immune cell production of Interleukin-17A in the gut and eventually showed significantly worse stroke outcomes ( 46 ). Fabian et al.…”
Section: Discussionmentioning
confidence: 94%
“…As the same time, we used the Eubacteria primers as an internal reference for total bacteria (or as the housekeeping gene). These primers are universal eubacteria community primers (UniF340 and UniR514), which represent all bacteria and are widely used in qRT-PCR and 16S rDNA studies to determine bacterial abundance or capture the 16S rDNA of all bacteria (Wang et al, 1996;Lawley et al, 2017;Kuhbandner et al, 2019;Chen et al, 2022). The target threshold cycle (Ct) for the relative qRT-PCR expression results was divided by the internal reference Ct using the delta-delta Ct method.…”
Section: Discussionmentioning
confidence: 99%