Periodontitis severity relationship with metabolic syndrome: A systematic review with meta‐analysis

Abstract

The objective of this study was to investigate the association between periodontitis severity and metabolic syndrome (MetS) through systematic review, registered in PROSPERO: CRD42021232120. Selected articles were independently chosen by three reviewers from six databases, including using article reference lists, up until March 2022. Eligible studies were observational, without language limitation, and in subjects aged at least 18 years. The methodological quality of selected studies was assessed using the Newcastle‐Ottawa Scale. Random effects models calculated summary measurements (odds ratio‐OR, 95% confidence interval, 95%CI). The I2 test evaluated the statistical heterogeneity of the data. Sensitivity, subgroup, and meta‐regression analyses were performed. For the reliability of evidence, the Grading of Recommendations, Assessment, Development, and Evaluations tool was used. A total of 2133 records were identified, and 14 studies were included comprising 24,567 participants. The summary odds ratio showed a positive association between individuals with moderate (ORadjusted = 1.26; 95%CI = 2.10–5.37; I2 = 45.85%), and severe periodontitis (ORadjusted = 1.50; 95%CI:1.28–1.71; I2 = 56.46%), and MetS. Subgroup and meta‐regression analyses showed that study effect size was influenced by year of publication, study design, and MetS diagnostic criteria, contributing to inter‐study variability. The findings showed that moderate and severe levels of periodontitis are associated with MetS, suggesting a possible dose–response effect.

Effects of probiotics in rats with experimental metabolic syndrome and periodontitis: An investigation of the intestine–adipose tissue axis

“…Patients with MS present approximately two times higher risk to develop periodontitis than the rest of the population 32 . On the other hand, periodontitis increases the risk of worsening metabolic and systemic inflammatory parameters in these patients 4,33 . Thus, strategies with effects on these conditions with bidirectional relations are crucially needed.…”

“…32 On the other hand, periodontitis increases the risk of worsening metabolic and systemic inflammatory parameters in these patients. 4,33 Thus, strategies with effects on these conditions with bidirectional relations are crucially needed. These prevention or treatment alternatives could even exert a major influence in public health programs worldwide.…”

Periodontitis: An often-neglected complication of diabetes

“…The inflammatory process in periodontal tissues may release several cytokines into the systemic circulation along with bacterial toxins potentially aggravating the IR. There is also clear evidence for a significant association between MetS and periodontitis as evidenced by a very recent systematic review examining the interlink[ 15 ]. This meta-analysis, including 24567 participants from 14 studies, showed that the adjusted odds ratio (OR) for MetS among patients with moderate periodontitis was 1.26 and those with severe periodontitis was 1.50.…”

A novel nomogram for predicting risk of hypertension in US adults with periodontitis: National Health and Nutrition Examination Survey (NHANES) 2009–2014

“…[2][3][4] According to research, there are several additional chronic diseases like cancer, diabetes, cardiovascular disease (CVD), and neurological disorders that are associated with periodontitis. [5][6][7][8][9][10][11][12][13] This work was supported by the Fuzhou Key Specialty Project (Grant number 20191005), and the Fuzhou "14th Five-Year Plan" Clinical Specialty Training and Cultivation Construction Project, (Grant number 20220103).…”

“…[2–4] According to research, there are several additional chronic diseases like cancer, diabetes, cardiovascular disease (CVD), and neurological disorders that are associated with periodontitis. [5–13] Therefore, determining periodontitis risk is crucial for the avoidance and management of related chronic diseases.…”