Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

Ertuğrul, Abdullah Seçkin; Arslan, Uğur; Dursun, Recep; Hakkı, Sema S.

doi:10.1038/ijos.2013.30

Cited by 63 publications

(28 citation statements)

References 44 publications

(56 reference statements)

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“…As the implementation of our sample collection had excluded those subjects with periodontal inflammation or other oral diseases, we could assume that the abundance shift of Porphyromonas had something to do with OLP state. Our findings supported the results of a previous study, in which higher periodontopathogens’ percentages were detected in OLP groups than those in the non-OLP groups 27 . This periodontopathogenic genus with high percentage may also play an important role in the etiology of OLP.…”

Section: Discussionsupporting

confidence: 92%

Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus

Wang

et al. 2016

Sci Rep

119

115

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Several studies have explored the origin and development mechanism of oral lichen planus (OLP) with limited attention to the role of bacteria in the progression of this common oral disease. Here we utilized MiSeq sequencing of 16S rRNA gene amplicons to identify complex oral microbiota associated with OLP from saliva samples of two subtypes (reticular and erosive) of OLP patients and healthy controls. Our analyses indicated that the overall structure of the salivary microbiome was not significantly affected by disease status. However, we did observe evident variations in abundance for several taxonomic groups in OLP. Porphyromonas and Solobacterium showed significantly higher relative abundances, whereas Haemophilus, Corynebacterium, Cellulosimicrobium and Campylobacter showed lower abundances in OLP patients, as compared with healthy controls. In addition, we explored specific microbial cooccurrence patterns in OLP, and revealed significantly fewer linkers of Streptococcus comprising species in erosive OLP. Furthermore, the disease severity and immune dysregulation were also genusassociated, including with Porphyromonas that correlated to disease scores and salivary levels of interleukin (IL)-17 and IL-23. Overall, this study provides a general description of oral microbiome in OLP, and it will be useful for further investigation of their potential roles in the initiation and immune modulation of OLP.Lichen planus is a common chronic mucocutaneous inflammatory disease affecting skin, oral, genital mucosa, scalp and nails. The prevalence of oral lichen planus (OLP) ranges from 0.1-4% in the general population, and females between 30 and 60 are more vulnerable to this disease 1 . Lesion manifestations can often persist for years alternating between periods of quiescence and exacerbation 2 . Intraorally, OLP presents as white striations, papules, plaques, mucosal atrophy, erosions or blisters, mainly affecting the buccal mucosa, tongue, gingiva and lips 3 . Among those clinical phenotypes, the reticular form is the most prevalent lesion characterized by the presence of Wickham striae and usually asymptomatic. Whereas the erosive type, although less frequent, always causes different degrees of discomfort and soreness, it may need ongoing concern due to its malignant potential 4 . Despite of numerous literatures appraising the OLP origin and development mechanism, its aetiology remains uncertain, and the pathogenesis of this disease still needs more investigations. Several internal and external factors have been implicated, such as immunodeficiencies and microbial infection 5 . Several lines of evidences have suggested that immune dysregulation and complex cytokine network played important roles in the exacerbation and perpetuation of OLP 6,7 . For instance, a high proportion of the novel CD4 + T helper cells subset-Th17 cells were detected in OLP lesions 8 . And interleukin (IL)-17 and IL-23, the newly discovered Th17-associated cytokines, were found to be important proinflammatory factors involved in OLP 9,10 . In...

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Section: Discussionsupporting

confidence: 92%

Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus

Wang

et al. 2016

Sci Rep

119

115

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“…[ 33 ] Recently, it has been found in some literature that few periodontopathogenic microorganisms are also associated with the patients of OLP. [ 34 ] Role of candida infection is controversial in OLP. Several studies have shown an increased prevalence of candida species.…”

Section: Etiologymentioning

confidence: 99%

Oral lichen planus: An update on etiology, pathogenesis, clinical presentation, diagnosis and management

2015

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The mouth is a mirror of health or disease, a sentinel or early warning system. The oral cavity might well be thought as a window to the body because oral manifestations accompany many systemic diseases. In many instances, oral involvement precedes the appearance of other symptoms or lesions at other locations. Oral lichen planus (OLP) is a chronic mucocutaneous disorder of stratified squamous epithelium of uncertain etiology that affects oral and genital mucous membranes, skin, nails, and scalp. LP is estimated to affect 0.5% to 2.0% of the general population. This disease has most often been reported in middle-aged patients with 30-60 years of age and is more common in females than in males. The disease seems to be mediated by an antigen-specific mechanism, activating cytotoxic T cells, and non-specific mechanisms like mast cell degranulation and matrix metalloproteinase activation. A proper understanding of the pathogenesis, clinical presentation, diagnosis of the disease becomes important for providing the right treatment. This article discusses the prevalence, etiology, clinical features, oral manifestations, diagnosis, complications and treatment of oral LP.

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“…Since these OLP patients were asymptomatic, the differences in microbial species and quantity found in OLP lesions are most likely due to OLP disease process but not patients' inadequate hygiene maintenance caused by soreness/discomfort from these OLP lesions. Although the clinical types (erosive or reticular) and presence or absence of symptoms were not specified, Ertugrul et al [11] also found that the proportion of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola in total bacteria were higher in subgingival plaque samples taken from subjects having periodontitis and OLP than those having periodontitis without OLP. The results of these studies suggest that there may be correlation between the microbe and OLP.…”

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confidence: 99%

Dysbiosis of saliva microbiome in patients with oral lichen planus

Wang

et al. 2020

BMC Microbiol

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Background: Oral microbiota is not only important for maintaining oral health but also plays a role in various oral diseases. However, studies regarding microbiome changes in oral lichen planus (OLP) are very limited. To the best of our knowledge, there has been only two studies investigating salivary microbiome changes in OLP. Therefore, the purpose of this study was to identify the characteristic microbial profile in the saliva of OLP patients, with or without erosive lesions, and compare that with recurrent aphthous ulcer (RAU), a common oral immunological disorder that also shows multiple erosive/ulcerative lesions. Whole saliva samples were collected from 20 patients with OLP (erosive E, n = 10 and non-erosive NE, n = 10), 10 patients with RAU (U) and 10 healthy controls (C). DNA was extracted from the saliva samples, and the 16S rDNA gene V4 hypervariable region was analyzed using Illumina sequencing. Results: We obtained 4949 operational taxonomic units (OTUs) from the V4 region in all saliva samples. Community composition analysis showed a clear decreased relative abundance of genera Streptococcus and Sphingomonas in saliva from RAU patients when compared to the other three groups. Relative abundance of Lautropia and Gemella were higher in E group, whereas relative abundance of Haemophilus and Neisseria were higher in NE group when compared to C group. Abiotrophia and Oribacterium were higher in OLP (combining E and NE groups), while Eikenella and Aggregatibacter were lower when compared to C group. There was statistically significance in α-diversity between E and RAU groups(p < 0.05). Significant differences in β-diversity were detected in bacteria between E and C; NE and C; as well as E and NE groups. The LDA effect size algorithm identified the g_Haemophilus might be the potential biomarker in NE group. Conclusions: We found that salivary microbiome in erosive OLP was significantly different from that found in RAU; and these changes may be related to the underlying disease process rather than presence of ulcerative/erosive lesions clinically. In addition, our findings in bacterial relative abundance in OLP were significantly different from the previously reported findings, which points to the need for further research in salivary microbiome of OLP.

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Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

Cited by 63 publications

References 44 publications

Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus

Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus

Oral lichen planus: An update on etiology, pathogenesis, clinical presentation, diagnosis and management

Dysbiosis of saliva microbiome in patients with oral lichen planus

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