Perioperative Allogenic Blood Transfusion in Renal Cell Carcinoma: Risk Factors and Effect on Long-term Outcomes

Soria, Francesco; Martino, Michela de; Leitner, Carmen V.; Moschini, Marco; Shariat, Shahrokh F.; Klatte, Tobias

doi:10.1016/j.clgc.2016.12.002

Cited by 16 publications

(11 citation statements)

References 23 publications

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“…The impact of perioperative blood transfusion (BT) on survival outcomes has been reported in several urological and non-urological surgeries ( 1 , 2 ). Considering bladder cancer (BCa) patients, radical cystectomy (RC) with bilateral pelvic lymph node dissection represents the standard of care in muscle invasive and recurrent high risk non-muscle invasive disease ( 3 ).…”

mentioning

confidence: 99%

The impact of perioperative blood transfusion on survival outcomes in radical cystectomy patients

Moschini¹

2017

Transl. Androl. Urol.

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confidence: 99%

The impact of perioperative blood transfusion on survival outcomes in radical cystectomy patients

Moschini¹

2017

Transl. Androl. Urol.

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“…The sample size thus was too small to show statistical significance differences between the groups [17]. A French group also was not able to show a benefit of the use of hemostatic agents in robotic partial nephrectomy [18]. Using the autologous fibrin glue Vivostat ® in 10 patients in laparoscopic partial nephrectomy immediate hemostasis could be achieved and have been confirmed by another group in 28 patients again.…”

Section: Discussionmentioning

confidence: 95%

“…Blood loss itself might be correlated to a worse oncological outcome. It has been shown, that the perioperative transfusion of blood is related to a worse oncological outcome (HR 1.79) [18]. Thus, any effort must be taken to reduce the loss of blood during and after surgery to avoid transfusions.…”

Section: Discussionmentioning

confidence: 99%

Polyethylene glycol-coated collagen patch (hemopatch®) in open partial nephrectomy

et al. 2021

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Purpose To describe the results of a polyethylene glycol-coated collagen patch, Hemopatch® on blood loss, surgical time and renal function in partial nephrectomy (PN) for renal cell carcinoma (RCC). Methods Out of a single surgeon cohort of n = 565 patients undergoing conventional open PN (CPN) between 01/2015 and 12/2017 at the University of Munich a consecutive subgroup (n = 42) was operated on using a polyethylene glycol-coated collagen-based sealant Hemopatch® (Baxter International Inc., Deerfield, IL, USA) (HPN). Results Median age was 65.2 years (range 12.7–95.2) with median follow-up of 9.43 months (0.03–49.15). Baseline renal function (CKD-EPI) was 78.56 ml/min/1.73 m2 (range 20.38–143.09) with a non-significant decline to 74.78 ml/min/1.73 m2 (range 3.75–167.74) at follow-up. In CPN 46% had low complexity, 33% moderate complexity and 20% high complexity lesions with 33% low, 40% moderate and 27% high complexity masses in HPN. Median tumor size was 4.3 cm (range 1–38 cm) in CPN with 4.8 cm (range 3.8–18.3 cm) with HPN, p = 0.293. Median blood loss and duration of surgery was significantly lower in the HPN group vs. CPN (146 ml ± 195 vs. 114 ml ± 159 ml; p = 0.021; 43 min ± 27 for HPN vs. 53 min ± 49; p = 0.035) with no difference in clamping time (12.6 min ± 8.6 for HPN vs. 12.0 min ± 9.5; p = 0.701). Conclusions Hemopatch® supported renoraphy shows promising results compared to standard renoraphy in PN. No side effects were seen. Further studies should evaluate the prevention of arterio-venous or urinary fistulas. In complex partial nephrectomies Hemopatch® supported renoraphy should be considered.

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“…In fact, the effect of blood transfusion on the survival of patients with malignant diseases remains controversial. In the last decades, several studies showed that blood transfusion is an independent poor prognostic factor for survival in patients with many kinds of solid tumor [ 3 – 8 , 10 ]. Others showed that blood transfusion did not affect survival in patients with gastric or bladder cancer [ 9 , 22 – 24 ].…”

Section: Resultsmentioning

confidence: 99%

Prognostic Significance of Blood Transfusion in Elderly Patients with Primary Diffuse Large B-Cell Lymphoma

Fan

Hong

et al. 2018

BioMed Research International

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The current study sought to evaluate whether blood transfusions affect survival of elderly patients with primary diffuse large B-cell lymphoma (DLBCL). A total of 104 patients aged 60 years and over were enrolled and divided into two groups: 24 patients who received transfusions and 80 patients who did not. Statistical analyses showed significant differences in LDH levels, platelet (Plt) counts, and hemoglobin (Hb) and albumin (Alb) levels between the two groups. Univariate analyses showed that LDH level ≥ 245 IU/L, cell of origin (germinal center/nongerminal center), and blood transfusion were associated with both overall survival (OS) and progression-free survival (PFS). Higher IPI (3–5), Alb level < 35 g/L, and rituximab usage were associated with OS. Appearance of B symptoms was associated with PFS. Multivariate analyses showed that cell of origin and rituximab usage were independent factors for OS and LDH level was an independent factor for PFS. Blood transfusion was an independent factor for PFS, but not for OS. Our preliminary results suggested that elderly patients with primary DLBCL may benefit from a restrictive blood transfusion strategy.

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Perioperative Allogenic Blood Transfusion in Renal Cell Carcinoma: Risk Factors and Effect on Long-term Outcomes

Cited by 16 publications

References 23 publications

The impact of perioperative blood transfusion on survival outcomes in radical cystectomy patients

The impact of perioperative blood transfusion on survival outcomes in radical cystectomy patients

Polyethylene glycol-coated collagen patch (hemopatch®) in open partial nephrectomy

Prognostic Significance of Blood Transfusion in Elderly Patients with Primary Diffuse Large B-Cell Lymphoma

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