“…Patients who develop relapsed infections often require additional surgery and longer courses of both intravenous (IV) and oral antimicrobials, which are associated with additional side effects. Intravenous antimicrobials have toxicities similar to chemotherapy including neutropenia, fatigue, nausea and vomiting, and diarrhea [ 7 ]. PJI impacts not only a patient’s mobility but all aspects of a patient’s life.…”