Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival

Buijs, Nikki; Schueren, Marian A.E. de van der; Langius, J.A.E.; Leemans, C. René; Kuik, Dirk J.; Vermeulen, Mechteld A. R.; Leeuwen, Paul A. M. van

doi:10.3945/ajcn.2010.29532

Cited by 102 publications

(66 citation statements)

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“…With the appearance of ARG, decreased T cell proliferation, low expression of specific T cell receptors and decreased production of cytokines have been observed (Mussai et al, 2013). Perioperative arginine-enriched nutrition significantly improved the long-term overall survival and long-term disease-specific survival in malnourished patients with head and neck cancer (Buijs et al, 2010). Higher expression and activity of ARG1 are often observed in the blood of cancer patients (Polat et al, 2003;Grabon et al, 2009;Rodriguez et al, 2009).…”

Section: Discussionmentioning

confidence: 97%

Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India

Srivastava

Ghosh²

2015

Asian Pacific Journal of Cancer Prevention

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Background: Arginine may play important roles in tumor progression by providing ornithine for polyamine biosynthesis, required for cell growth. The aim of this work was to determine the expression of arginine metabolic pathway enzymes in head and neck squamous cell carcinoma (HNSCC) in northeast India. Materials and Methods: The expressions of arginase isoforms (ARG1 and ARG2), ornithine aminotransferase (OAT) and ornithine decarboxylase (ODC) were examined in fifty paired HNSCC and adjacent non-tumor tissues by immunohistochemistry. Immunocytochemistry, semiquantitative reverse transcription sq-PCR and quantitative real-time qPCR were used to assess protein and mRNA expressions in peripheral blood of fifty HNSCC patients and hundred controls. Results: ARG1 and ODC protein and mRNA were strongly expressed in peripheral blood from HNSCC patients. No ARG2 expression was observed. In vivo, expression of ARG1, ARG2 and ODC was significantly higher in tumor than in non-tumor tissues. Most tumors expressed low levels of OAT, with no difference in tissues or blood, compared to controls. The absolute extent of maximal ARG1 upregulation with qPCR showed 6.23 fold increase in HNSCC. Conclusions: These findings strongly suggest that in HNSCCs, the ARG1 pathway is stimulated leading to the formation of polyamines as indicated by higher ODC expression, which promote tumor growth.

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Section: Discussionmentioning

confidence: 97%

Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India

Srivastava

Ghosh²

2015

Asian Pacific Journal of Cancer Prevention

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“…Die Langzeitbeobachtung von 32 Patienten mit Kopf-Hals-Tumoren über 10 Jahre, die perioperativ eine mit Arginin angereicherte Diät erhalten hatten, zeigte für die Interventionsgrupe ein signifikant besseres Langzeit-und tumorspezifisches Überleben sowie signifikant weniger lokoregionäre Tumorrezidive [7].…”

Section: Sondenernährungunclassified

Ernährung bei operativen Maßnahmen

Weimann

2016

Onkologe

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Ernährung bei operativen MaßnahmenMangelernährung wird allgemein im Zusammenhang mit Fasten und Hunger bei Fehlen von Nahrung assoziiert. Im Rahmen einer Tumorerkrankung führt ein krankheitsassoziierter Gewichtsverlust gerade bei Patienten mit Überge-wicht, wenn überhaupt, sehr spät zu einem niedrigen Körpermassenin-dex (Body Mass Index, BMI) mit der Definition der Unterernährung durch die Weltgesundheitsorganisation (WHO) < 18,5 kg/m 2 . Der Gewichtsverlust für sich bedeutet jedoch eine Veränderung der Körperzusam-mensetzung, die ein "metabolisches Risiko" nach sich zieht, welches bei Patienten vor großen Tumoroperationen berücksichtigt werden muss.

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“…Randomized controlled trials (RCTs) indicate that interventions based on enteral or parenteral nutrient supplementations, when prescribed in parallel with chemoradiotherapy or surgery, may improve quality of life and reduce therapy related side-effects and mortality. [3][4][5][6].…”

Section: Introductionmentioning

confidence: 98%

Does cachexia prevention improve outcome of chronic disease and cancer?

2011

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Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival

Abstract: Perioperative arginine-enriched enteral nutrition significantly improved the long-term overall survival and long-term disease-specific survival in malnourished patients with head and neck cancer.

Cited by 102 publications

References 39 publications

Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India

Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India

Ernährung bei operativen Maßnahmen

Does cachexia prevention improve outcome of chronic disease and cancer?

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