Perioperative assessment of platelet function by Thromboelastograph® Platelet Mapping™ in cardiovascular patients undergoing non-cardiac surgery

Cattano, Davide; Altamirano, Alfonso; Kaynak, Husnu E.; Seitan, Carmen; Paniccia, Rita; Chen, Zhongxue; Huang, Hanwen; Prisco, Domenico; Hagberg, Carin A.; Pivalizza, Evan G.

doi:10.1007/s11239-012-0788-5

Cited by 38 publications

(31 citation statements)

References 23 publications

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“…Other reports have stated the use of different parameters provided by these tests are predictors of both postoperative bleeding and blood product use [143][144][145] . Thrombelastograph Platelet Mapping System has been developed to monitor antiplatelet therapy [146][147][148][149] . A weak clot is formed by the addition of reptilase and factor XIII, by adding AA or ADP the clot strength is increased allowing this assay to be sensitive to dual antiplatelet therapy.…”

Section: Viscoelastic Methodsmentioning

confidence: 99%

Assessment of platelet function: Laboratory and point-of-care methods

Paniccia¹

2014

WJTM

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In the event of blood vessel damage, human platelets are promptly recruited on the site of injury and, after their adhesion, activation and aggregation, prevent blood loss with the formation of a clot. The consequence of abnormal regulation can be either hemorrhage or the development of thrombosis. Qualitative and/or quantitative defects in platelets promote bleeding, whereas the residual reactivity of platelets, despite antiplatelet therapies, play an important role in promoting arterial thrombotic complications. Platelet function is traditionally assessed to investigate the origin of a bleeding syndrome, to predict the risk of bleeding prior surgery or during pregnancy or to monitor the efficacy of antiplatelet therapy in thrombotic syndromes that, now, can be considered a new discipline. "Old" platelet function laboratory tests such as the evaluation of bleeding time and the platelet aggregation analysis in platelet-rich plasma are traditionally utilized to aid in the diagnosis and management of patients with platelet and hemostatic disorders and used as diagnostic tools both in bleeding and thrombotic diathesis in specialized laboratories. Now, new and renewed automated systems have been introduced to provide a simple, rapid assessment of platelet function including point of care methods. These new methodologies are also suitable for being used in non-specialized laboratories and in critical area for assessing platelet function in whole blood without the requirement of sample processing. Some of these methods are also beginning to be incorporated into routine clinical use and can be utilized as not only as first panel for the diagnosis of platelet dysfunction, but also for monitoring anti-platelet therapy and to potentially assess risk of both bleeding and/or thrombosis.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Platelets; Method; Test; Point of care testing; Laboratory assessment; Bleeding; Thrombosis; Platelet function Core tip: This review discussed the scenario of available platelet function laboratory and point-of-care methods suitable in different clinical setting. As this matter has become of crucial importance in the bleeding management and for monitoring antiplatelet therapies, improved ability to assess platelet function in a timely and efficient manner is essential. Traditional platelet function methods, requiring a fair degree of expertise, have been limited to specialized laboratory. Many efforts have been carried out for improving platelet function assays for centralized laboratory, such as different point-of-care testing methodologies have been developed. Moreover, different guidelines and recommendations for their method standardization are growing.

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Section: Viscoelastic Methodsmentioning

confidence: 99%

Assessment of platelet function: Laboratory and point-of-care methods

Paniccia¹

2014

WJTM

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“…Platelet aggregation is initiated through adding arachidonic acid (AA) or adenosine diphosphate (ADP) to a sample of blood and the effects of platelet activation on blood clot formation are analysed. Identification of antiplatelet medication is enabled through the use of TEG-PM [40]. For assessment of platelet function through the POC device Platelet Function Analyser (PFA)-100 (Siemens Diagnostics, Deerfield, IL, USA) a sample of citrated whole blood is aspirated at shear rates through disposable cartridges.…”

Section: Poc Assessment Of Platelet Functionmentioning

confidence: 99%

Point of care coagulation testing in neurosurgery

Beynon

Unterberg

Sakowitz

2015

Journal of Clinical Neuroscience

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“…Thromboelastography (TEG) is widely used as a monitoring technique for hemostasis in surgical procedures 10 11. It is performed in whole blood and assesses clot formation and can be used to test the inhibitory response to antiplatelet agents such as aspirin and clopidogrel 12–14.…”

Section: Introductionmentioning

confidence: 99%

Use of thromboelastography to tailor dual-antiplatelet therapy in patients undergoing treatment of intracranial aneurysms with the Pipeline embolization device

McTaggart

Choudhri

Marcellus

et al. 2014

J NeuroIntervent Surg

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Platelet function testing with TEG altered our DAT induction strategy in a significant number of cases. No hemorrhagic or disabling thromboembolic complications were seen in this series. Future studies should compare methods of platelet function testing and, possibly, no platelet function testing in neurovascular patients undergoing flow diversion and/or stent-assisted treatment of intracranial aneurysms.

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Perioperative assessment of platelet function by Thromboelastograph® Platelet Mapping™ in cardiovascular patients undergoing non-cardiac surgery

Abstract: According to the findings, the TEG PM assay might be a feasible approach to objectively evaluate the effects of aspirin and clopidogrel during the perioperative period and potentially guide drug management.

Cited by 38 publications

References 23 publications

Assessment of platelet function: Laboratory and point-of-care methods

Assessment of platelet function: Laboratory and point-of-care methods

Point of care coagulation testing in neurosurgery

Use of thromboelastography to tailor dual-antiplatelet therapy in patients undergoing treatment of intracranial aneurysms with the Pipeline embolization device

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