Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing non-cardiac surgery

Pre-operative beta-blocker therapy does not affect short-term mortality after esophageal resection for cancer

“…The presence of adverse effects such as stroke or death following β-blocker treatment in surgical patients have been recorded [ 26 ]. In contrast to the POISE (Peri Operative Ischemic Evaluation) trial in 2008 [ 26 ], several studies have shown an association between decreased mortality and β-blocker therapy for patients undergoing non-cardiac surgery [ 4 – 7 , 19 , 27 ]. Unlike the POISE trial, it can be assumed that the β-blocker therapy received by each patient in the current study was in a dose applied for each specific individual in contrast to the POISE trial where β-blocker “naïve” patients received a high dose of long-acting metoprolol despite major differences in co-morbidities, reason for surgery and the surgical procedure performed [ 26 ].…”

The Cochrane Anaesthesia Review Group at 20: achievements and challenges in systematic reviews of evidence in peri‐operative care

“…The aim is to produce reviews that are open access and high quality, with transparent and rigorous methodology. The Anaesthesia Group's scope includes: pre‐operative assessment and preparation [1–4]; regional anaesthesia [5]; intra‐operative management [6–8]; and postoperative complications and care, including acute pain management [9,10]. There is also a separate Review Group dedicated to Emergency and Critical Care.…”

Perioperativer Schlaganfall

“…Im Gegensatz dazu wurde 2008 in einer multizentrischen randomisierten Studie nachgewiesen, dass der unmittelbar präoperative Einnahmebeginn von β-Blockern in hoher Dosierung mit Schlaganfällen nach nichtkardiochirurgischen Eingriffen assoziiert ist [53]. Die Ursache könnte in einer Reduktion des Herzzeitvolumens durch eine bradykardisierende und blutdrucksenkende Wirkung mit unzureichender Möglichkeit der Bedarfsadaptation liegen [54]. Darüber hinaus muss darauf hingewiesen werden, dass die in der…”