Perioperative blood transfusion: does it influence survival and cancer progression in metastatic spine tumor surgery?

Abstract

This is the first study providing evidence that disease progression and survival in patients who undergo MSTS are less likely to be influenced by perioperative ABT. The worst oncologic outcomes are more likely to be caused by the clinical circumstances necessitating blood transfusion, but not transfusion itself. However, because ABT can have a propensity toward developing postoperative infections, including surgical site infection, the use of patient blood management interventions would be worthwhile rather than relying solely on ABTs for these patients, if and whenever possible.

Prognostic Differences in Patients with Solitary and Multiple Spinal Metastases

“…Our results revealed that patients with multiple spinal metastases did not have a significantly shorter survival time compared to patients with solitary spinal metastasis, which is completely opposite from certain existing literature and scoring systems 8, 9 and 11. The obtained findings are in accordance with previous reports from the literature: Yang et al . found that the median survival for patients with SSM was 7 months, while it was 5 months for patients with MSM.…”

Metastatic spine tumor surgery: does perioperative blood transfusion influence postoperative complications?

“…The patients were categorized into different subgroups based on primary tumor type, type of surgical approaches, levels of instrumentation, and decompression as in our previous studies in MSTS. 21,25,26 Categorical variables are presented as numbers with percentages and continuous variables as mean 6 SD as per the distribution of data. Fisher's exact test was used for comparing categorical variables and t test was used for continuous variables.…”

“…Statistical analyses were performed using statistical software (STATA, Release 13.0, StataCorp). The patients were categorized into different subgroups based on primary tumor type, type of surgical approaches, levels of instrumentation, and decompression as in our previous studies in MSTS …”

“…On the other hand, some studies have refuted that blood transfusion did not increase the incidence of postoperative complications or infections . In patients undergoing MSTS, there have been studies in current literature that have evaluated the impact of ABT on survival with no emphasis on postoperative complications . With this background, we performed a retrospective analysis of the data of patients undergoing surgery for spinal metastases to explicate the influence of perioperative ABT on the spectrum of postoperative complications and infections.…”

Immunmodulation durch Transfusion von Erythrozytenkonzentraten

“…Je seltener ein einzelnes Ereignis ist, desto schwieriger ist es, dies auch in großen Studien oder Metaanalysen zu erfassen. [52,53], während andere keinen Zusammenhang zeigen [54,55] (▶ Tab. 1).…”