Perioperative Blood Transfusion Requirements in Pediatric Scoliosis Surgery

Grant, J. A.; Howard, Jason; Luntley, Jeremy; Harder, James A.; Aleissa, Sami; Parsons, David

doi:10.1097/bpo.0b013e31819a85de

Cited by 101 publications

(54 citation statements)

References 27 publications

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“…Sethna et al [27] used a higher dose of TXA at 100 mg/kg load followed by 10 mg/kg/h, while Neilipovitz et al [28] used a lower dose loading at 10 mg/kg followed by 1 mg/kg/h. In a recent study, when two TXA dosing regimens were evaluated, a dose-dependent effect of TXA on the transfusion requirements was recorded [29]. Although only adolescent idiopathic scoliosis patients were examined, the number of patients included in the study was too low, while surgeries were performed by different surgeons.…”

Section: Discussionmentioning

confidence: 99%

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

Lykissas

Crawford

Chan

et al. 2013

Journal of Children's Orthopaedics

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Purpose Intraoperative blood loss in scoliosis surgery often requires transfusions. Autogenous blood decreases but does not eliminate risks typically associated with allogenic blood transfusion. Costs associated with transfusions are significant. Tranexamic acid (TXA) has been shown to decrease blood loss in cardiac and joint surgery. Few studies have examined its use in pediatric spine surgery, and the results are inconsistent. The aim of this study was to determine whether TXA decreases intraoperative blood loss and transfusion requirements in adolescent idiopathic scoliosis patients undergoing posterior spinal fusion by a single surgeon. Methods The medical records and operative reports of surgically treated patients with adolescent idiopathic scoliosis between 2000 and 2009 were retrospectively reviewed. The inclusion criteria were: (1) patients who underwent instrumented posterior spinal fusion, (2) had complete medical records, and (3) were treated by the same surgeon. Forty-nine patients who met the inclusion criteria were divided into two groups: Group A (25 patients) received TXA, while Group B (24 patients) did not receive TXA.Results After controlling for age at the time of surgery, gender, and number of vertebral levels fused, the mean intraoperative blood loss was significantly lower in Group A (537 ml) than in Group B (1,245 ml) (p = 0.027). The mean volume of blood transfused intraoperatively was 426 and 740 ml for Group A and Group B, respectively. The difference was not statistically significant after controlling for age, gender, and number of levels fused (p = 0.078). Conclusion TXA significantly decreased intraoperative blood loss in posterior spinal fusions performed for adolescent idiopathic scoliosis.

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Section: Discussionmentioning

confidence: 99%

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

Lykissas

Crawford

Chan

et al. 2013

Journal of Children's Orthopaedics

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show abstract

“…Recently, Grant et al 21 showed that, during pediatric scoliosis surgery, the use of TXA decreased the number of intraoperative PRBC transfusions by 50%. In children undergoing craniofacial surgery, only two studies 22,23 showed the effectiveness of an antifibrinolytic drug in reducing intraoperative blood loss.…”

Section: -21mentioning

confidence: 99%

Intraoperative Tranexamic Acid Reduces Blood Transfusion in Children Undergoing Craniosynostosis Surgery

Dadure¹,

Sauter²,

Bringuier³

et al. 2011

Anesthesiology

212

183

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“…In some institutions, anesthesia protocols are standard in scoliosis surgery which leads to limitations in the study 23 . As well, in randomized-control trials, patients' demographic data such as age, gender, body mass index, medical history vary between the two groups contributing to alteration in the results, but such differences are minor and of little or no clinical relevance.…”

Section: Discussion:-mentioning

confidence: 99%

Efficacy of Tranexamic Acid in Reducing Blood Loss and Blood Transfusion in Idiopathic Scoliosis; A Systematic Review and Meta-Analysis.

Ajmi¹,

Saeed²,

Faryan³

et al. 2017

IJAR

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Perioperative Blood Transfusion Requirements in Pediatric Scoliosis Surgery

Abstract: III, retrospective cohort study.

Cited by 101 publications

References 27 publications

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

Intraoperative Tranexamic Acid Reduces Blood Transfusion in Children Undergoing Craniosynostosis Surgery

Efficacy of Tranexamic Acid in Reducing Blood Loss and Blood Transfusion in Idiopathic Scoliosis; A Systematic Review and Meta-Analysis.

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