This project aims to evaluate the outcomes of patients with medically refractory movement disorders treated with deep brain stimulation (DBS) following implementation of a standardized care pathway. Aims included decreasing length of stay (LOS), improving cost efficiency, reducing unintended 30-day readmission rates, and optimizing overall patient care.Methods: A quality improvement project was conducted at a single, large academic medical center located in the southeastern United States and focused on adult patients (>18yrs) with Parkinson's disease, essential tremor, or dystonia undergoing initial DBS implantation. A multidisciplinary team was developed and a value stream mapping (VSM) analysis of the DBS process was performed to identify areas of unnecessary cost, inefficiency, and potential improvement. An evidence-based DBS clinical pathway was developed and implemented into practice including updating patient education materials, perioperative order sets, anesthesia protocols and a patient satisfaction survey. Pre-implementation (N=150) and postimplementation (N=29) cohorts were statistically compared for differences in LOS, readmission rates and cost, during stage 2 (electrode implantation) of the DBS process.Results: A significant predictor of increased LOS was living in a rural county (p=0.010).Increased cost was associated with age >65 (p<0.0001), primary diagnosis essential tremor (p=0.050), and ethnicity (p=0.004). Readmission rates are higher in patients with >2 baseline medical comorbidities (p<0.001) and males have a significantly shorter interval to readmission than women (p=0.013).