Perioperative change in peripheral blood monocyte count may predict prognosis in patients with colorectal liver metastasis after hepatic resection

Haruki, Koichiro; Shiba, Hiroaki; Fujiwara, Yuki; Furukawa, Kenei; Wakiyama, Shigeki; Ogawa, Masaichi; Ishida, Yuichi; Misawa, Takeyuki; Yanaga, Katsuhiko

doi:10.1002/jso.23033

Cited by 29 publications

(29 citation statements)

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“…A correlation between monocytosis and poor prognosis in different types of cancer has previously been observed (16,(25)(26)(27). Monocytes represent a source of chemokines and cytokines that contribute to inflammation (28).…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 89%

Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer

et al. 2016

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Abstract.A correlation between the lymphocyte-to-monocyte ratio (LMR) and the survival of patients with hematological malignancies has been reported previously. However, there have been few studies investigating the prognostic significance of LMR in patients with solid tumors. The aim of the present study was to evaluate the prognostic significance of preoperative LMR in patients with colorectal cancer (CRC). A total of 189 patients undergoing potentially curative surgery for CRC were enrolled. The LMR was calculated from preoperative blood samples by dividing absolute lymphocyte count by absolute monocyte count. A cut-off value of 4.8 was set based on the receiver operating characteristic curve; 116 patients were classified as high-LMR, and 73 patients classified as low-LMR. The high-LMR group exhibited significantly better relapse-free survival (P=0.0018) and overall survival (P=0.0127) rates than the low-LMR group. According to the multivariate analysis of survival, preoperative LMR was identified as an independent prognostic factor for relapse-free survival (P=0.041) and overall survival (P=0.031). Therefore, preoperative LMR is a useful prognostic marker in patients with CRC. IntroductionColorectal cancer (CRC) is the third most common cancer and fourth leading cause of cancer-associated mortality worldwide (1). Despite advances in surgical procedures and adjuvant chemotherapy, 20-25% of patients still experience relapse following curative surgery (2). The Union for International Cancer Control (UICC) tumor node metastasis (TNM) staging system (3) is currently the most reliable indicator of patient prognosis and is widely used amongst practitioners. However, there are differences in patient prognosis even within the same TNM stage. Therefore, more reliable markers are required to improve predictions of cancer recurrence and patient survival.It has previously been reported that inflammation is important in determining cancer progression (4,5). Inflammation-based indices, such as the C-reactive protein level, Glasgow prognostic score, and neutrophil-to-lymphocyte ratio; are useful for predicting the prognosis of patients with CRC as well as various other types of cancer (6-9). Recent studies investigating various types of malignancies have demonstrated a correlation between the lymphocyte-to-monocyte ratio (LMR), which also reflects the degree of systemic inflammation, and patient survival (10-14). However, the prognostic value of the LMR has mainly been investigated in patients with hematological malignancies, with few reports focusing on patients with solid tumors. Therefore, the aim of this retrospective study was to evaluate the prognostic significance of preoperative LMR in patients with CRC who are able to undergo potentially curative surgery. Materials and methods Patients.A total of 189 patients with CRC were enrolled. All patients underwent potentially curative surgery for CRC in the Department of Surgical Oncology, Osaka City University, between January 2007 and December 2009. Patients who received ...

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Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 89%

Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer

et al. 2016

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“…The Glasgow prognostic score (GPS), which is calculated by the combination of serum C-reactive protein (CRP) and albumin concentrations, and the elevated preoperative neutrophil-to-lymphocyte ratio (NLR), have been revealed to predict cancer-specific survival (7)(8)(9)(10)(11)(12). The previous study reported negative impact of GPS on post-operative complications following hepatic resection (13,14), and the association between perioperative immunological response and prognosis subsequent to hepatic resection for HCC (15,16) and CRLM (17). In the present study, the association between preoperative peripheral blood neutrophil count and disease-free, as well as overall survival, following elective hepatic resection for patients with CRLM was retrospectively investigated.…”

Section: Introductionmentioning

confidence: 99%

Preoperative peripheral blood neutrophil count predicts long-term outcomes following hepatic resection for colorectal liver metastases

et al. 2017

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“…Reportedly, preoperative variables, including decreased lymphocyte count, increased monocyte count, and elevated neutrophil‐to‐lymphocyte ratio, are associated with poor prognosis in cancer patients 32, 33. In addition, perioperative changes in peripheral blood monocyte counts are independent risk factors for OS after hepatectomy and may reflect an immunosuppressive state 34. In this study, PBMC and LMNC counts, including those of lymphocytes and monocytes, of the group receiving neoadjuvant chemotherapy were not less than those of the group primarily receiving hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis

Hirata

Ishiyama

Tanaka

et al. 2018

Annals of Gastroent Surgery

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AimWe investigated the chemotherapy effect of resectable colorectal cancer with liver metastasis (CRLM) on the function of intrahepatic immune cells.MethodsWe classified patients into adjuvant chemotherapy (bevacizumab+CapeOX) after hepatectomy group (group A) and neoadjuvant chemotherapy followed by hepatectomy group (group B), and collected peripheral blood mononuclear cells (PBMC) and liver mononuclear cells (LMNC) to ascertain phenotypic and functional differences.ResultsThere were no significant differences in lymphocyte fractions of either PBMC or LMNC between groups, except for the significantly lower percentage of natural killer (NK) cells in LMNC in group B than in group A. Significantly higher percentage of natural‐killer group 2, member D (NKG2D)‐ positive NK cells in PBMC and percentage of tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐, NKp30‐, and signal regulatory protein β (SIRPβ)‐positive NK cells in LMNC were found in group B. Furthermore, significantly higher expressions of NKG2D and SIRPβ in peripheral blood NK cells and of NKp46 and CD122 in liver NK cells were found in group B. When LMNC were incubated with interleukin (IL)‐2 in vitro, no difference was observed in the expression of these molecules in NK cells between groups. Consistently, there was no difference in the cytotoxic activity of those LMNC against a colon adenocarcinoma cell line between groups.ConclusionColorectal cancer with liver metastasis patients treated with neoadjuvant chemotherapy showed enhanced expression of activation markers on peripheral blood and liver NK cells in comparison with patients who did not receive therapy; however, the difference in those function remains unclear. These results suggest that neoadjuvant chemotherapy does not have a negative impact on intrahepatic immune cells in resectable CRLM patients.

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Perioperative change in peripheral blood monocyte count may predict prognosis in patients with colorectal liver metastasis after hepatic resection

Abstract: Perioperative change in peripheral blood monocyte count is an independent risk factor for overall survival after hepatic resection for CRLM, and may reflect immunosuppressive state.

Cited by 29 publications

References 40 publications

Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer

Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer

Preoperative peripheral blood neutrophil count predicts long-term outcomes following hepatic resection for colorectal liver metastases

Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis

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