Perioperative changes in oral bacteria number in patients undergoing cardiac valve surgery

Suzuki, Hitomi; Matsuo, Koichiro; Okamoto, Mitsumasa; Nakata, Haruka; Sakamoto, Hitomi; Fujita, M

doi:10.2334/josnusd.18-0380

Cited by 10 publications

(9 citation statements)

References 27 publications

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“…Our data further reveal that the abundance of Fusobacterium in T-site at CRC stage III but not in other conditions is higher than those in oral cavity with CRC ( Figure 3 A). However, the absolute total number of bacteria in colon is higher than that in oral cavity (10 11 CFU/mL in colon vs 10 7 CFU/mL in oral cavity) [ 47 , 48 ]. Therefore, the absolute number of Fusobacterium in colon is higher than that in oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Differential Mucosal Microbiome Profiles across Stages of Human Colorectal Cancer

Zhang

Hou

et al. 2021

Life

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Emerging evidences link gut microbiota to colorectal cancer (CRC) initiation and development. However, the CRC stage- and spatial-specific bacterial taxa were less investigated, especially in a Chinese cohort, leading to our incomplete understanding of the functional roles of gut microbiota in promoting CRC progression and recurrence. Here, we report the composition and structure of gut microbiota across CRC stages I, II and III, by analyzing the gut mucosal microbiomes of 75 triplet-paired samples collected from on-tumor, adjacent-tumor and off-tumor sites and 26 healthy controls. We observed tumor-specific pattern of mucosal microbiome profiles as CRC progressed and identified ten bacterial taxa with high abundances (>1%) as potential biomarkers for tumor initiation and development. Peptostreptococcus and Parvimonas can serve as biomarkers for CRC stage I. Fusobacterium, Streptococcus, Parvimonas, Burkholderiales, Caulobacteraceae, Delftia and Oxalobacteraceae can serve as biomarkers for CRC stage II, while Fusobacterium, Burkholderiales, Caulobacteraceae, Oxalobacteraceae, Faecalibacterium and Sutterella can serve as biomarkers for CRC stage III. These biomarkers classified CRC stages I, II and III distinguished from each other with an area under the receiver-operating curve (AUC) > 0.5. Moreover, co-occurrence and co-excluding network analysis of these genera showed strong correlations in CRC stage I, which were subsequently reduced in CRC stages II and III. Our findings provide a reference index for stage-specific CRC diagnosis and suggest stage-specific roles of Peptostreptococcus, Fusobacterium, Streptococcus and Parvimonas in driving CRC progression.

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Section: Discussionmentioning

confidence: 99%

Differential Mucosal Microbiome Profiles across Stages of Human Colorectal Cancer

Zhang

Hou

et al. 2021

Life

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“…For these subjects, implementation of oral care intervention was impossible during the acute stage. The number of bacteria on the tongue surface is known to increase after 2 or 3 days following surgical operation [ 33 , 34 , 35 ]. The oral condition of patients at the acute stage may be similar to that of patients immediately after surgical operation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Mucosal Brushing on the Serum Levels of C-Reactive Protein for Patients Hospitalized with Acute Symptoms

et al. 2020

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This study was based in a hospital setting. Patients with acute symptoms face a life-threatening crisis and often have systemic complications during the convalescence stage. During the acute stage, oral function does not work and oral hygiene status deteriorates. A gauze or sponge brush is generally used to wipe the oral cavity; however, this process does not clean the oral cavity enough. Effective oral care requires better methods. Patients participating in this study were all hospitalized by ambulance and with acute symptoms. During the convalescence stage, patients were assigned application of mucosal brushing or wiping by gauze or sponge brush by order of hospitalization. The effects were evaluated by the number of bacteria on the tongue surface, serum C-reactive protein (CRP) and body temperature. Changes in bacterial count, body temperature, and CRP were effectively reduced in the mucosal brushing group compared to the wiping by gauze or sponge brush group. Based on mixed effect modeling, the coefficient of mucosal brushing for CRP was −2.296 and for body temperature was −0.067 and statistically significant. This simple method can effectively prevent systemic complication of inpatients with deteriorated oral conditions. This method may also be effective for the elderly in nursing homes or perioperative oral-care management.

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“…However, previous studies comparing multiple locales reported that the microorganisms count was highest on the tongue surface. Therefore, the number of microorganisms on the tongue surface could be representative of the majority of microorganisms within the entire oral cavity 39,40 . Fourth, we did not assess detailed systemic factors, including the variety and severity of stroke or ADL.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the number of microorganisms on the tongue surface could be representative of the majority of microorganisms within the entire oral cavity. 39,40 Fourth, we did not assess detailed systemic factors, including the variety and severity of stroke or ADL. Assessment of these factors could have allowed a more detailed evaluation of the relationship between systemic factors and the microorganism number on the tongue surface.…”

Section: F I G U R Ementioning

confidence: 99%

Factors associated with the number of microorganisms on the tongue surface in patients following acute stroke

Furuya

Beniya

Suzuki

et al. 2020

J of Oral Rehabilitation

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Background Oral hygiene management of patients with acute stroke is important for preventing aspiration pneumonia and ensuring oral intake. The tongue coating score can be useful for evaluating the oral hygiene level since it reflects the microorganism number on the tongue surface in elderly patients. However, the relationship between the number of oral microorganisms and the tongue coating score in patients with acute stroke remains unclear. Objectives We aimed to investigate the relationships between the microorganism number on the tongue surface and oral factors, including tongue coating score, tongue surface moisture level and tongue function. Methods This cross‐sectional study enrolled 73 patients with acute stroke who were hospitalised at an acute care hospital and underwent dental intervention. Potential explanatory factors, including sex, age, Glasgow Coma Scale score, tongue coating score, tongue surface moisture level, nutrition intake method, number of functional teeth and tongue function, were evaluated. Logistic regression analysis determined their association with the microorganism number on the tongue surface. Results The tongue coating score (odds ratio: 1.31) and tongue surface moisture level (odds ratio: 1.10) were significantly associated with increased microorganism numbers on the tongue surface. Conclusion The tongue coating score, which reflects the actual number of microorganisms on the tongue surface, could be an effective tool for evaluating oral hygiene level in patients with stroke. Moreover, reducing oral microorganisms in saliva through oral hygiene management, including removing the tongue coating, could contribute towards the prevention of aspiration pneumonia.

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Perioperative changes in oral bacteria number in patients undergoing cardiac valve surgery

Cited by 10 publications

References 27 publications

Differential Mucosal Microbiome Profiles across Stages of Human Colorectal Cancer

Differential Mucosal Microbiome Profiles across Stages of Human Colorectal Cancer

Effect of Mucosal Brushing on the Serum Levels of C-Reactive Protein for Patients Hospitalized with Acute Symptoms

Factors associated with the number of microorganisms on the tongue surface in patients following acute stroke

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