Perioperative cytokine release during coronary artery bypass grafting in patients of different ages

Roth-Isigkeit, Angela; Schwarzenberger, J; Borstel, T van; Gehring, Hartmut; Ocklitz, Evelyn; Wagner, KF; Schmucker, P.; Seyfarth, M

doi:10.1046/j.1365-2249.1998.00682.x

Cited by 28 publications

(12 citation statements)

References 54 publications

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“…Consistent with our previous reports on perioperative cytokine release and the results of other studies, peak concentrations of IL‐6, TNF‐ α and IL‐1 β were found on the day of surgery after operation [32–34]. On the first and second postoperative days, serum concentrations of sIL‐2R were significantly elevated compared to pre‐ and intra‐operative values.…”

Section: Discussionsupporting

confidence: 91%

Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass

Roth-Isigkeit¹,

Hasselbach²,

Ocklitz³

et al. 2001

Clinical and Experimental Immunology

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SUMMARYCardiac surgery with cardiopulmonary bypass (CPB) leads to a systemic inflammatory response with secretion of cytokines (e.g. IL-6, TNF-a , IL-1b and sIL-2R). The objective of the following study was to investigate in vitro and in vivo cytokine responses and white blood cell counts (WBC) of patients with high versus low cytokine secretion after a coronary artery bypass grafting (CABG) procedure. Twenty male patients undergoing elective CABG surgery with CPB under general anaesthesia were enrolled in the study. On the day of surgery (postoperatively), serum levels of TNF-a and IL-1b were significantly higher in patients of the high IL-6 level group compared to the respective values in the patient group with low IL-6 levels. The inter-individual differences in IL-6 release in patients undergoing CABG surgery with CPB were accompanied by differences in the release of other cytokines, such as TNF-a , IL-1b and sIL-2R. To understand whether genetic background plays a role in influencing cytokine plasma levels under surgical stress, we examined the distribution of polymorphic elements within the promoter regions of the TNF-a and IL-6 genes, and determined their genotype regarding the BAT2 gene and TNF-b intron polymorphisms. Our preliminary data suggests that regulatory polymorphisms in or near the TNF locus, more precisely the allele set 140/150 of the BAT2 microsatellite marker combined with the G allele at 2308 of the TNF-a gene, could be one of the genetic constructions providing for a less sensitive response to various stimuli. Our results suggest: (1) close relationships between cytokine release in the postoperative period, and (2) inter-individually varying patterns of cytokine release in patients undergoing CABG surgery with CPB.

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Section: Discussionsupporting

confidence: 91%

Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass

Roth-Isigkeit¹,

Hasselbach²,

Ocklitz³

et al. 2001

Clinical and Experimental Immunology

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“…The release pattern of both CRP and SAA in our control patients has been observed by others. [31][32][33][34][35][36] The increase in CRP and SAA over time was significantly reduced in patients receiving GIK.…”

Section: Discussionmentioning

confidence: 99%

Glucose, insulin and potassium applied as perioperative hyperinsulinaemic normoglycaemic clamp: effects on inflammatory response during coronary artery surgery

Visser

Zuurbier

Hoek

et al. 2005

British Journal of Anaesthesia

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“…Study design, cardiopulmonary bypass technique and cytokine determinations were identical to those described previously [13].…”

Section: Methodsmentioning

confidence: 99%

Perioperative serum levels of tumour-necrosis-factor alpha (TNF-α), IL-1β, IL-6, IL-10 and soluble IL-2 receptor in patients undergoing cardiac surgery with cardiopulmonary bypass without and with correction for haemodilution

Roth-Isigkeit¹,

Borstel²,

Seyfarth

et al. 1999

Clinical and Experimental Immunology

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SUMMARYCardiac surgery with cardiopulmonary bypass (CPB) leads to a systemic inflammatory response with secretion of cytokines. Alterations in the serum concentrations of cytokines have important prognostic significance. Reports on cytokine release during cardiac surgery with CPB have yielded conflicting results. Haemodilution occurs with the onset of CPB resulting in large fluid shifts during the perioperative course of cardiac procedures. In the present study we compare the perioperative course of serum concentrations of TNF-a, IL-1b, IL-6, IL-10 and sIL-2R with and without correction for haemodilution in patients undergoing coronary artery bypass grafting (CABG) surgery. Twenty male patients undergoing elective CABG surgery with CPB and general anaesthesia using a balanced technique with sufentanil, isoflurane and midazolam were enrolled into the study. Serum levels of TNFa, IL-1b, IL-6, IL-10 and sIL-2R were measured using commercially available ELISA kits. Simultaneous haematocrit values were obtained at all sample times. Statistical analysis was performed by nonparametric analysis of variance and t-tests for data corrected for haemodilution and data that were not corrected for haemodilution. Adjusted significance level was P < 0·01. Intra-operatively, up to the second post-operative day PCV values were significantly decreased compared with preoperative values. Cytokine measurements not corrected for haemodilution were significantly lower than the corrected values. The perioperative haemodilution and decrease in PCV may lead to an underestimation of the cytokine secretion in post-operative patients. We conclude that cytokine measurements were significantly influenced by the perioperative haemodilution and the subsequent decrease in PCV and may in part account for the varying results reported in the literature regarding cytokine release in patients undergoing CABG surgery.

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Perioperative cytokine release during coronary artery bypass grafting in patients of different ages

Cited by 28 publications

References 54 publications

Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass

Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass

Glucose, insulin and potassium applied as perioperative hyperinsulinaemic normoglycaemic clamp: effects on inflammatory response during coronary artery surgery

Perioperative serum levels of tumour-necrosis-factor alpha (TNF-α), IL-1β, IL-6, IL-10 and soluble IL-2 receptor in patients undergoing cardiac surgery with cardiopulmonary bypass without and with correction for haemodilution

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