“…11 Moreover, concerns have arisen regarding the high incidence of hypoglycemia in association with intensive glucose control [8][9][10]12 and the possibility that hypoglycemia may offset its potential benefits. 11 Despite these reservations, however, tight glucose control may be beneficial for some populations 11,13,14 and clearly requires additional study. 11,15,16 In this sub-study, we reported on the validation of our insulin infusion algorithm in terms of time to achieve target, percent of time spent within desired range, incidence of severe and moderate hypoglycemia, and glucose variability.…”