Perioperative high-dose-rate brachytherapy in soft tissue sarcomas of the extremity and superficial trunk in adults: Initial results of a pilot study

Martı́nez-Monge, Rafael; Julián, Mikel San; Cambeiro, Mauricio; Arbea, Leire; Valero, J.; González‐Cao, María; Martín‐Algarra, Salvador

doi:10.1016/j.brachy.2005.06.003

Cited by 25 publications

(19 citation statements)

References 23 publications

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“…The worse results recorded in upper limb STS may depend on the greater difficulty of radical surgery in this dimensionally smaller and richer of neurovascular bundles area. Table 3 shows the results of the comparison between other studies [7,12,13,14,18,22] and our results. Local control and OS were similar to that recorded in other centers despite inclusion of intermediate-high grade (HG) STS only.…”

Section: Discussionmentioning

confidence: 86%

“…Local control and OS were similar to that recorded in other centers despite inclusion of intermediate-high grade (HG) STS only. On the contrary, in other published studies, the analyzed populations also included low grade (LG) STS, generally showing a better prognosis [7,12,13,14,18,22]. The favorable impact of adjuvant radiation therapy on LC compared to surgery alone has been shown in several studies [7,12,13,14,18,22].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, most available studies are retrospective and analyze limited number of patients [8,13,14,15,16,17]. Furthermore, these studies included patients with different risk categories (low, intermediate, high).…”

Section: Purposementioning

confidence: 99%

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Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas

Cortesi¹,

Frakulli²,

Galuppi³

et al. 2017

European Journal of Cancer

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Purpose: The standard primary treatment for soft tissue sarcoma (STS) is a wide surgical resection, preceded or followed by radiotherapy. Purpose of this retrospective study was to assess the efficacy of perioperative brachytherapy (BRT) plus postoperative external beam radiation therapy (EBRT) in patients with intermediate-high risk STS.Material and methods: BRT delivered dose was 20 Gy. External beam radiation therapy was delivered with 3D-technique using multiple beams. The prescribed dose was 46 Gy to the PTV. Neoadjuvant and adjuvant chemotherapy (CHT) was used in patients with potentially chemosensitive histological subtypes. The primary aim of the study was to analyze overall survival (OS) and local control (LC) in a large patient population treated with surgery, perioperative BRT, and adjuvant EBRT ± CHT. Secondary objective was to identify prognostic factors for patients outcome in terms of LC, disease-free survival (DFS), and OS.Results: From 2000 to 2011, 107 patients presenting 2-3 grade (FNLCC) primary or recurrent STS were treated with surgery, perioperative BRT, and adjuvant EBRT ± CHT. Five-year LC and OS were 80.9% and 87.4%, respectively. At univariate analysis, a higher LC was recorded in primary vs. recurrent tumors (p = 0.015), and in lower limb tumors vs. other sites (p = 0.027). An improved DFS was recorded in patients with lower limb tumors vs. other sites (p = 0.034).Conclusions: The combination of BRT and EBRT was able to achieve satisfactory results even in a patients population with intermediate-high risk STS. Patients with recurrent or other than lower limb sited tumors show a worse LC.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas

Cortesi¹,

Frakulli²,

Galuppi³

et al. 2017

European Journal of Cancer

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“…Martinez et al (10), in their series treated 36% of the patients with low-grade STS by brachytherapy boost. The ABS guidelines (17) available then, at the time of starting our study, also recommended the use of adjuvant EBRT alone or in combination with implant boost for patients with low-grade STS who require adjuvant therapy.…”

Section: Discussionmentioning

confidence: 98%

“…Although brachytherapy is usually not recommended for low-grade STS, but there is some literature (10,17) regarding its use for low-grade STS as well, but as a boost. Martinez et al (10), in their series treated 36% of the patients with low-grade STS by brachytherapy boost.…”

Section: Discussionmentioning

confidence: 98%