Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: A randomised trial

Leong, Jee-Yoong; Merwe, Johan van der; Pepe, Salvatore; Bailey, Michael; Perkins, Anthony V.; Lymbury, Robyn; Esmore, Donald; Marasco, Silvana; Rosenfeldt, Franklin

doi:10.1016/j.hlc.2010.06.659

Cited by 54 publications

(46 citation statements)

References 24 publications

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“…The activity of GPx is known to be critically dependent upon circulating selenium levels [9] which is confirmed by our findings of a strong correlation between GPX and selenium in both groups. Interestingly, it has recently been reported that cardiac surgical patients who received a perioperative selenium supplementation showed a reduced extent of myocardial damage [34]. Also in our patients, we could observe an inverse correlation between the postoperatively measured selenium and CK-MB levels.…”

Section: Discussionsupporting

confidence: 71%

The Importance of Intraoperative Selenium Blood Levels on Organ Dysfunction in Patients Undergoing Off-Pump Cardiac Surgery: A Randomised Controlled Trial

et al. 2014

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IntroductionCardiac surgery is accompanied by an increase of oxidative stress, a significantly reduced antioxidant (AOX) capacity, postoperative inflammation, all of which may promote the development of organ dysfunction and an increase in mortality. Selenium is an essential co-factor of various antioxidant enzymes. We hypothesized a less pronounced decrease of circulating selenium levels in patients undergoing off-pump coronary artery bypass (OPCAB) surgery due to less intraoperative oxidative stress.MethodsIn this prospective randomised, interventional trial, 40 patients scheduled for elective coronary artery bypass grafting were randomly assigned to undergo either on-pump or OPCAB-surgery, if both techniques were feasible for the single patient. Clinical data, myocardial damage assessed by myocard specific creatine kinase isoenzyme (CK-MB), circulating whole blood levels of selenium, oxidative stress assessed by asymmetric dimethylarginine (ADMA) levels, antioxidant capacity determined by glutathionperoxidase (GPx) levels and perioperative inflammation represented by interleukin-6 (IL-6) levels were measured at predefined perioperative time points.ResultsAt end of surgery, both groups showed a comparable decrease of circulating selenium concentrations. Likewise, levels of oxidative stress and IL-6 were comparable in both groups. Selenium levels correlated with antioxidant capacity (GPx: r = 0.720; p<0.001) and showed a negative correlation to myocardial damage (CK-MB: r = −0.571, p<0.001). Low postoperative selenium levels had a high predictive value for the occurrence of any postoperative complication.ConclusionsOPCAB surgery is not associated with less oxidative stress and a better preservation of the circulating selenium pool than on-pump surgery. Low postoperative selenium levels are predictive for the development of complications.Trial registrationClinicalTrials.gov NCT01409057

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Section: Discussionsupporting

confidence: 71%

The Importance of Intraoperative Selenium Blood Levels on Organ Dysfunction in Patients Undergoing Off-Pump Cardiac Surgery: A Randomised Controlled Trial

et al. 2014

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“…coronary artery bypass surgery [60]. Of the 117 participants 60 participants received magnesium orotate, lipoic acid, omega-3 fatty acids, selenium and coenzyme Q10 2 months prior to surgery and one month after surgery.…”

Section: Leong Et Al Presented Interesting Data Involving Patients Umentioning

confidence: 99%

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Alehagen

Aaseth

2015

Journal of Trace Elements in Medicine and Biology

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“…Some types of elective surgery such as coronary artery bypass graft are true models of ischemia reperfusion and therefore are associated with severe oxidative stress [49]. Numerous studies have investigated the clinical significance of oxidative stress and possibility for its modulation in these settings [50,51]. Similarly, repair of abdominal aortic aneurysm is associated with significant ischemia-reperfusion injury and oxidative stress.…”

Section: Clinical Significance Of Oxidative Stressmentioning

confidence: 99%

Oxidative Stress in Laparoscopic Versus Open Abdominal Surgery: A Systematic Review

Arsalani‐Zadeh

Ullah

Khan

et al. 2011

Journal of Surgical Research

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Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: A randomised trial

Cited by 54 publications

References 24 publications

The Importance of Intraoperative Selenium Blood Levels on Organ Dysfunction in Patients Undergoing Off-Pump Cardiac Surgery: A Randomised Controlled Trial

The Importance of Intraoperative Selenium Blood Levels on Organ Dysfunction in Patients Undergoing Off-Pump Cardiac Surgery: A Randomised Controlled Trial

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Oxidative Stress in Laparoscopic Versus Open Abdominal Surgery: A Systematic Review

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