Perioperative Neurocognitive Function in Glioma Surgery

Noll, Kyle R.; Bradshaw, Mariana; Sheppard, David; Wefel, Jeffrey S.

doi:10.1007/s11912-024-01522-9

Curr Oncol Rep

2024

DOI: 10.1007/s11912-024-01522-9

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Perioperative Neurocognitive Function in Glioma Surgery

Kyle R. Noll,

Mariana Bradshaw,

David Sheppard

et al.

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2024

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Cited by 2 publications

References 97 publications

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Factors contributing to variability in neurocognitive performance before glioma neurosurgery

Lövgren,

Voets,

Isaac

et al. 2024

Neuro-Oncology Practice

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Background Cognitive impairment following anti-tumor treatment is a common concern for brain tumor patients. However, growing evidence indicates that significant impairments can be present even before treatment. The purpose of this study was to identify factors that explain variability in pre-treatment test performance, beyond that of tumor burden. Methods Using multi-step linear regression, we retrospectively probed the contribution of clinical-, tumor-, patient-, and self-reported factors to variance in performance among 96 treatment-naïve brain tumor patients across 13 objective neurocognitive tests. Agreement between subjective and objective reports of cognitive impairment was also examined. Results Clinically significant pre-operative impairments were observed in both objective and subjective domains. Estimated premorbid intelligence quotient (IQ), tumor volume, diagnosis of an astrocytoma, self-reported Depression and perceived Cognitive Functioning Scores were the most common predictors of objective neurocognitive performance prior to treatment, explaining 12.3%-58.3% of the variance. No association was identified between objective and subjective reports of cognitive impairment. Conclusions Glioma patients frequently exhibit objective and subjective impairments prior to treatment. Both tumor- and self-reported factors were identified as predictors of performance, after correcting for estimated premorbid IQ. Nevertheless, more than 41.7% of the variance in cognitive performance remained unexplained, indicating a substantial role for additional, as yet unaccounted for, clinical factors. Notable disparity between objective- and subjective cognitive impairment status re-emphasizes the importance of assessing both domains to ascertain a patient’s overall functioning in the context of treatment outcomes.

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Factors contributing to variability in neurocognitive performance before glioma neurosurgery

Lövgren,

Voets,

Isaac

et al. 2024

Neuro-Oncology Practice

View full text Add to dashboard Cite

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An Overview of Reviews on Predictors of Neurorehabilitation in Surgical or Non-Surgical Patients with Brain Tumours

Gambarin,

Malgrati,

Di Censo

et al. 2024

Life

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(1) Background. People suffering from brain cancer, regardless of histological tumour characteristics, often experience motor disturbances, cognitive–behavioural difficulty, language impairments, and functional and social limitations. The current treatment approach entails surgery and adjuvant therapy such as chemotherapy and radiotherapy combined with intensive rehabilitation. The primary focus of rehabilitation is usually motor and functional recovery, without specifically addressing the patient’s quality of life. The present systematic review identifies and evaluates the predictors of functional and cognitive rehabilitation outcomes and their influence on quality of life in adult patients with brain cancer. (2) Methods. Three electronic databases (PubMed, Elsevier, Cochrane) were searched for reviews about functional, cognitive, and quality-of-life outcomes in patients with central nervous system tumours, including articles published between January 2018 and May 2024. (3) Results. The search retrieved 399 records, 40 of which were reviewed. Five main areas of predictive factors were identified: diagnosis, therapy, complications, outcomes (in the motor, cognitive, and quality-of-life categories), and tailored rehabilitation. (4) Conclusions. These indicators may inform integrated care pathways for patients with primary central nervous system tumours.

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Perioperative Neurocognitive Function in Glioma Surgery

Cited by 2 publications

References 97 publications

Factors contributing to variability in neurocognitive performance before glioma neurosurgery

Factors contributing to variability in neurocognitive performance before glioma neurosurgery

An Overview of Reviews on Predictors of Neurorehabilitation in Surgical or Non-Surgical Patients with Brain Tumours

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