Perioperative Oral Nutrition Supplementation Reduces Prevalence of Sarcopenia following Radical Cystectomy: Results of a Prospective Randomized Controlled Trial

Diet and Exercise Are not Associated with Skeletal Muscle Mass and Sarcopenia in Patients with Bladder Cancer

“…The crosssectional nature of this study does not imply causal relationships between risk factors and body composition. This study does not determine whether further muscle wasting can be prevented with structured and targeted physical activity and nutritional interventions, and in fact, recent clinical trials suggest that improving body composition may be possible [28]. The findings of this study are primarily applicable to long-term survivors.…”

<p>Optimal Delivery of Follow-Up Care After Radical Cystectomy for Bladder Cancer</p>

“…Patients relatively often experience symptoms of ileus and abdominal pain on day 3 or 4 postoperatively, and reduced oral intake may necessitate parenteral treatment in order to avoid starvation and increased sarcopenia. 43,44 Studies investigating the best modality for delivering nutritional support postoperatively to RC patients are few, and if oral intake was limited, parenteral nutrition was considered to be the standard mode of care until recently.…”

“…While the relationship between nutritional status and perioperative outcomes is accepted, there is limited evidence to support specific nutrition intervention protocols, as well as a lack of consistent guidelines and recommendations for nutrition supplementation in most postoperative ERPs. 43,44 A few studies have investigated the effects and benefits of parenteral nutrition in improving recovery from RC. 45,46 One minor RCT study concluded that, when compared to oral administration, parenteral administration led to increased infectious complications and higher costs during a patient's hospital stay without any difference in LOS.…”

“…The study demonstrated that giving patients nutrition intervention with enriched supplements twice a day in the perioperative period may be more likely to preserve skeletal muscle mass and reduce the prevalence of sarcopenia, potentially improving outcomes and reducing readmissions. 44…”

Round up

“…In a prospective randomized controlled pilot trial, the effect of perioperative oral nutritional supplementation was studied on body composition and clinical outcomes. [ 9 ] Sixty-one patients were randomized to oral nutritional supplement or multivitamin and multi-mineral supplement twice a day for 8 weeks in the perioperative period. The primary outcome measured was difference in 30-day hospital-free days.…”