Perioperative outcomes following pelvic floor reconstruction in women with hereditary disorders of connective tissue: a retrospective cohort study

Pelvic Organ Prolapse in Ehlers-Danlos Syndrome

“…Pelvic pain was also reported in 71% of participants. The majority of perioperative studies in patients with hereditary connective tissue disorders focus on orthopedic or vascular procedures [ 2 ]. One study assessed postoperative outcomes after surgery for POP or SUI and found that after adjusting for age, there is no significant difference in complication rates between patients with hereditary disorders of connective tissue and controls [ 2 ].…”

“…However, patients with hereditary connective tissue disorders require special consideration in surgical planning due to tissue characteristics and increased propensity to bleed. Anatomic recurrence of POP did not differ between patients with EDS and those without [ 2 ]. Additionally, the rate of postoperative complications did not differ between those with connective tissue disorders and controls [ 2 ].…”

“…Anatomic recurrence of POP did not differ between patients with EDS and those without [ 2 ]. Additionally, the rate of postoperative complications did not differ between those with connective tissue disorders and controls [ 2 ].…”

“…The hypermobile EDS variant (type III) is the most common subtype and thought to be inherited in an autosomal dominant fashion with no known genetic mutation. While commonly associated with hyperextensible skin, hypermobile joints, and hematological manifestations including increased tendency to bleed, defects in collagen biosynthesis at a molecular level predispose to gynecologic and obstetric complications [ 2 ].…”

“…Female patients with EDS often have bothersome pelvic floor disorders including pelvic organ prolapse (POP) and stress urinary incontinence (SUI) [2][3][4]. These disorders can present at a young age without the typical risk factors such as pregnancy and delivery or menopause.…”